氰化物毒理学

(cyanide)KCNNaCNHCNNaCNKCNA1~2mg/kgHCN26.55.6~12.8%HCNCOHCNHCN60mgCNCO12H(respiratorychain)(electrontransferchain)H+eFe3+Fe2+,Fe2+Fe2+←→Fe3++e6aa3P4505COH2Saa3CCC2::A:ABALcytbcytc1:H2SCOCNATPOSCPH+TTFAFPFADQ3,CN42,Fe,,,,(cytochromeoxidaseE.C.1.9.3.1)Aaa3aa3aa3CN-a3(Fe3+)CN-ATP(peroxidaes)C1210-210-3M(schiffbase)-2-2--4-(2-keto-4-hydroxyglutaratealdolase)4a.Ca+NaCNb.pHc.NaCN(0.110.2mg/kg)3PQRSTS-Td.ATP/ADPpHKCNγ-Ca2+()(Tabum)CS-1.120005%1%3%2.CN-CN-CN-CN-CN-(B12)(CO2EDTA)1)()-2)1215301%1025ml(10mg/kg)35ml()1%10mg/kg(1%1ml/kg)2550%20ml25%0.250.5g/kg102012000