从基因到天然产物生物合成

There-emergenceofnaturalproductsfordrugdiscoveryinthegenomicsera药物基因组学教研室解鸿波NaturalproductsanddrugdiscoveryNaturalproductsandgenomicsFuturedirectionsandoutlookSourcesofNaturalproducts1234Whatarenaturalproducts?1.SourcesofNaturalproductsWhatarenaturalproducts?1.SourcesofNaturalproductsArtemisinin2.NaturalproductsanddrugdiscoveryMorphineQuininePaclitaxel6%27%25%5%37%AllsmallmoleculenewchemicalentitiesCommerciallyavailablechemicalspace22x106compoundsNaturalproductuniverse16x104compoundsNatural-productdatabasesDatabaseNumberofentriesAdditionalinformationSuperNaturalII355,0002DstructureswithvendorinformationUniversalNaturalProductDatabase197,2013DstructuresassembledfromotherdatabasesChineseNaturalProductDatabase53,000HasbeenusedinvirtualscreeniSMART20,000FromtraditionalChinesemedicinesAfroDb1,000FromAfricanmedicinalplantsInteractionsbetweendrugandtarget3.NaturalproductsandgenomicsInsightsintotheBiosynthesisInsightsintotheBiosynthesisGeneclusterBioinformaticstoolsantiSMASH3.0DiscovernewdrugleadsDiscovernewdrugleadsPromoterreplacementsandgenedeletions4.Futuredirectionsandoutlook“Therewasanintrinsicbeliefinthevalueofthemoleculeswe'reseeking.”–GregoryVerdine