LCST-类水凝胶开关效应的研究进展

:20029,:200343e2mail:[e-mail]3(100029)LCST,,pH,N2:O633122;Q819:A:10052281X(2004)0120056205AdvancesofLCST2HydrogelsAppliedasaMolecularSwitchSongJiangliWangXiufen3(TheKeyLaboratoryofScienceandTechnologyofControllableChemicalReactions,MinistryofEducation,BeijingUniversityofChemicalTechnology,Beijing100029,China)AbstractThedevelopmentoftheresearchofLCST2hydrogelsisreviewed.ThevariousmechanismsaboutvolumetransitionandeffectoffactorssuchashydrophobicPhydrophilicstructures,ionicityofmedia,pHandsoon,whichhaveinfluenceonthepropertiesofhydrogelsarebrieflydiscussed.Theapplicationsofthehydrogelsasamolecularswitcharealsodescribed,suchasdrugdelivery,substanceseparation,immobilizationofenzymes,electromagnetismrespondentde2vices.Keywordspoly(N2isopropylacrylamide)hydrogel;volumetransitionmechanism;molecularswitchLCST(lowercriticalsolutiontem2perature),,LCSTN2(p(NIPAAm)),(MVE),(HEMA),p(NIPAAm)LCST32,,,LCST,LCSTLCST,1.PNIPAAm2070,Tanaka[1],,Havsky[2]Flory,,2:(x-xc)32=0x216120041PROGRESSINCHEMISTRYVol.16No.1Jan.,2004©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.KonakBansil[3]Debye2Huckel,,Cussler[4],,Tanaka[5]ba,S:S=(bPa)4(2f+1)4,(f:)S290;S290,Eriksatomotso[6]PNIPAAmP,,,KubotaPNIPAAmLCST,PNIPAAm[7](510molPL)AAm2PNIPAAmR,[8]PNIPAAmC016,PNIPAAm2.NIPAAm,P,P:LCST,,,,,,PNIPAAm,LCST;Takei[9]NIPAAmN,N2,,LCST,,LCSTpHKokufuta[10]4p(NIPAAmPAAc),pH=3pH=10,,Yu[11]SAMAPRCNIPAAm,NIPAAm,,Zhang[12],,LCST,,,LCST,,LCSTYoo[13]pHNIPAAm2co2AAcLCST[14]NIPAAmPpH,Hoffman[15]NIPAAmPpH,,[16]PpNIPAAm,Zhang[17]PpNIPAAm,pH,pHGehrke[18]pNIPAAm,Otake[19]pNIPAAmPNIPAAm,751LCST©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.pNIPAAmLCST,Hirotsu[20]NIPAAmP,,,,,LCST1.,pNIPAAmpNIPAAmLCST,P,,,()Hoffman[21]NIPAAmPAAc,,,,,,LCST,,,;LCST,,,1987HoffmanNIPAAmP,Bae[22]NIPAAm2co2BMA(BMA:)[23]pNIPAAmBMA,pNIPAAm,2,pNIPAAm,LCST,,,,;LCST,,,pNIPAAmP2.,,LCSTp(NIPAAm):LCST,,;LCST,,,pNIPAAmKokufutaTanaka[24]pNIPAAm,,;,80minHoshino[25],NIPAAmP,,,[23]p(NIPAAm),,[26],Liu[27]p(NIPAAm),,3.,LCST,2080,Cussler[28]p(NIPAAm),Trank[29];Hoffman[30],,NIPAAmNIPAAmP[30],Koetsu[32]pNIPAAm2MAAcPAAc(MAAc:),,05V8516©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.Chen[33]p(NIPAAm)P,,,Cheol[34](AAc)AAc,p(NIPAAm)2AAc,[35]NIPAAmFe3O4Pp(St2NIPAAm)[36]NIPAAmPTanaka[37]p(NIPAAm),448nm,,Suzuki[38]NIPAAmPSAPpHAoki[39]NIPAAm2PBA()LCST,,p(NIPAAm)Hideki[40]100mp(NIPAAm),3050,,Sakuma[41]PVA2p(NIPAAm)PNVA2p(NIPAAm),,,,p(NIPAAm),,,,p(NIPAAm)NIPAAm,,LCST[1]TanakaT.Phys.Rev.Lett.,1978,40:820823[2]IlavskM.Polymer,1981,22:16871691[3]KonakC,BansilR.Polymer,1989,30:677680[4]MarchettiM,PragerS,CusslerEL.Macromolecules,1990,23:17601765[5]HirokawaY,TanakaT.J.Chem.Phys.,1984,81(12):part,63796380[6]MatsuoES.J.Chem.Phys.,1988,89:16951703[7](WuC),(WangXH),(GaoJ).(PolymerBull.),1998,3:916[8](ZengF),(TongZ),(SatoT).(Sci.ChinaSer.B),1999,(5):426431[9]TakeiYG,AokiT,SanuiK,etal.BioconjugateChem.,1993,4(5):341346[10]KokufutaE,WangBL,YoshidaR,etal.Macromolecules,1998,31(20):68786884[11]YuH,GraingerDW.J.Appl.Polym.Sci.,1993,49(9):15531563[12]ZhangYQ,TanakaT.Polym.Mater.Sci.Eng.,1992,66:369373[13]YooMK,SungYK,LeeYM,etal.Polymer,1998,39(16):37033708[14](JinMR),(WuCF),(WangSC).(ChemicalEngineering),1991,19(2):1318[15]DongLC,HoffmanAS.J.ControlledRelease,1991,15:141146[16](ZhouRX),(ZhangXZ).(ActaPolym.Sinica),1998,(1):3942[17]ZhangJ,PeppasNA.Macromolecules,2000,33(1):102107[18]GehrkeSH,PalasisM,AkhtarMK.Polym.Int.,1993,29(1):2935[19]OtakeK,KarakiR,EbinaT,etal.Macromolecules,1993,26(9):21942197[20]HirotsuSH,PalasisMK.Polym.Int.,1992,25(17):44454448[21]DongLC,HoffmanAS.J.ControlledRelease,1991,15:147152[22]BaeYH,OkanoT,HsuR,etal.Makromol.Chem.RapidCommun.,1987,8(10):481485[23](ZhouRX),(LiuF).(DoctoralDissertation),(WuhanUniversity),1993[24]KokufutaE,TanakaT.Macromol.,1991,24(7):16051607[25]HoshiniK,TaniguchiM,KatagiriM,etal.J.Chem.Eng.Jpn.,1992,25(5):569574951LCST©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.[26](LuoXG),(WangT).(DoctoralDissertation),(WuhanUniversity),1996[27]LiuF,ZhuoRX.Biotechnol.Appl.Biochem.,1995,21:257264[28]FreitasRFS,CusslerEL.Chem.Eng.Sci.,1987,42(1):97103[29]TrankSJ.FoodTechnol.,1989,43:7882[30]HoffmanAS,DongLC.J.ControlledRelease,1986,4(3):223227[31]OyamaN,TatsumaT,TakahashiK.J.Phys.Chem.,1993,97(40):1050410508[32]MoritaY,KaetsuT.Radiat.Phys.Chem.,1992,39(6):473477[33]ChenJH,MasaruY,YasunariM.Polymer,2001,42(23):93619365[34]CheolSB,SungK,KyungSKJ.EuropeanPolymerJournal,2003,39(3):579584[35](DingXB),(SunZH),(WangGX).(ActaPolymerSinica),1998,(5):628631[36](ShiXY),(SunCM),(WuSK).(PhotographicScienceandChemistry),1999,(1):3844[37]SuzukiA,TanakaT.Nature,1990,34(6):345347[38]SuzukiA,LshiiT,MaruyamaY.J.Appl.Phys.,1996,80(1):131136[39]GutowskiA,KimSW,BaeYH,etal.J.ControlledRelease,1992,22(2):95104[40]HidekiI,YoshinobuF.JounalofControlledRelease,2000,63(1P2):107119[41]ShinjiS,NorioS,RikaS.InternationalJournalofPharmaceutics,2002,239(1P2):1851950616©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.