阿魏酸的功能和应用_欧仕益

阿魏酸的功能和应用(暨南大学食品科学与工程系　广州　510632)　　,,、、。,、、、、、、。,,。、、、,。　,,,Abstract　Ferulicacid,4-(-hydroxy-3-methoxyphenyl)-2-propenoicacid,aneffectivecomponentofChinesemedicineherbs,suchasAngelicasinensis,CimicifugaheracleifoliaandLignsticumchuangxiong,isaubiquitousphenolicacidintheplantkingdom.Itismainlyconjugatedwithmono-andoligosaccharides,polyamines,lipidsandpolysaccharidesandseldomoccursinafreestateinplants.Ferulicacidisaphenolicacidoflowtoxicity;itcanbeabsorbedandeasilymetabolizedinthehumanbody.Ithasmanyphysiologicalfunctions,includingan-tioxidant,antimicrobial,anti-inflammatory,anti-thrombosis,andanti-canceractivities,andalsoprotectsagainstcoronarydisease,lowerscholesterolandincreasesspermviability.Becauseofthesepropertiesanditslowtoxicity,ferulicacidisnowwidelyusedinthefoodindustries.Itisusedastherawmaterialfortheproductionofvanillinandpreservatives,asacross-linkingagentforthepreparationoffoodgelsandediblefilms,andasaningredientinsportfoods.Ferulicacidcanbepreparedbychemicalsynthesisandthroughbiologicaltransformation.Keywords　Ferulicacid,Function,Preparation,Application　　4--3-,,,、、[1]。,,LD502445mg/kg,LD502113mg/kg。、、,。1　1.1　,,、、、[2]。。,,、、、[3]。,,,。KayaharaKawabata,:2002-8-20:,。,,,[5]。1.2　、、(TXA2),TXA2,(PGI2)/TXA2,。,,,A2(PLA2),TXA2。c-AMP。1.3　-5-,,。1.4　,、。、。。50《》　　　　　GuangzhouFoodScienceandTechnology　　　　　Vol.18No.4(73)-,3[5]:①-,,,。②-,,。,,、,、、,。③,TXA2。TXA2,(cAMP),Ca2+Ca2+Ca2+,,。、。、,[5]。1.5　、(RSV)。HirabayashiRAW264.7,,-843%56%,[6]。RSV-2,。[7]。,。,,、、、、、11[4]。N-,。1.6　Kawabata(AOM)F334,500mg/kg27%[8]。,、。Kawabata,、[8]。,、、[4]。2　:、。,(、、)。(),,。(、)。,、、、,,,[9]。,,,、,、[10]。,,[11]。3　。3.1　,,,。,,(3),,[12]。2.2　:,,。,γ-,1.5%-2.8%。90-100℃8h,pH。。,。,4%51《》　　　　　GuangzhouFoodScienceandTechnology　　　　　Vol.18No.4(73)24h。,。,,,0.5%[13],。(EC3.1.1.1)、[14]。、。,、,。,;,,、、pH;,;,。,,。。,。、、[15],20.0μmol/g()。,150mg/L,[16]。。4　,。,、、。,。4.1　,。[17]:,,;。,、。,,[17],。4.2　,。1975、。。,。。Heinonen、、、、、、、、-,[18]。pH,pH、[19]。,、。,[20],。,。Lattanzio125(Sclerotiniasclerotiorum、Fusariumoxysporum、Altenariasp.、Botrytiscinerea、Penicilliumdigitatum),[21]。,。4.3　,,,,。,、。,、。、,,,,,[22];,,[23]。,52《》　　　　　GuangzhouFoodScienceandTechnology　　　　　Vol.18No.4(73)。4.4　,。,[24],。、,,,。1　..:,19982　.,1997,116(2):603　ZhouenZetal.FreeRadicRes,1998,29(1):134　.,2001,24:2205　.,1999,1(2):1396　HirabayashiTetal.PlantaMed,1995,61(3):2217　ChanWSetal.AnticancerRes,1995,15(3):7038　KawabataKetal.CancerLett,2000,157(1):159　..,1993,18:300～30210　SchelineRR.CRChandbookofmammalianmetabolismofplantcompounds,CRCpress,BocaRaton,FL,199111　VirgiliFetal.Ferulicacidexcretionasamarkerofconsumptionofafrenchmaritimepine(pinusmaritima)barkextract.FreeRadic.Biol.Med,2000,28:1249～125612　AdamsR,BockstahlerTE.JAmChemSoc,1952,74,534613　.,2002,23(8):162～16514　KroonPAetal.JSciFoodAgric,1999,79:428～43415　GrabberJHetal.Phytochem,1995,40:107716　MadhaviDLetal.JAgricFoodChem,1997,45:150617　PriefertHetal.ApplMicrobilBiotechnol,2001,56:29618　HeinonenMetalJAgricFoodChem,1998,46:91719　FriedmanM,JurgensHS.JAgricFoodChem,2000,48:210120　MasudaTetal.JAgricFoodChem,2000,48:147921　LattanzioVetal.ItalJFoodSci,1994,1:2322　,.,2002(1):43～4623　O'ConnellJE,FoxPF.IntDairyJ,1999,9:52324　HeadleyS,MassadS.(1999)Nutritionalsupplementsforath-letes.NationalAssociationforSportandPhysicalEducation,andAssociationoftheAmericanAllianceforHealth,PhysicalEdu-cation,RecreationandDance,p51-52黄瓜变为黄瓜汁的启示,。,,。,,。。,,、,,、。,,。,,,。,,,。,、、、、,“”,,。,19962000,1398,131。,,,,。。,,,,。,。,;,。,,。,,、、、。,,。、、、,、。,、。()53《》　　　　　GuangzhouFoodScienceandTechnology　　　　　Vol.18No.4(73)