黄精多糖的功能活性及应用前景

41Vol.4No.120132JournalofFoodSafetyandQualityFeb.,2013基金项目:(21202557103)(BPHR2012C01)Fund:SupportedbyCooperationProjectwithJiuhuaMountainInstituteofPolygonatum(21202557103)andFundingProjectforAcademicHumanResourcesDevelopmentinBeijingUnionUniversity(BPHR2012C01)*通讯作者:,,,E-mail:[e-mail]*Correspondingauthor:ZHANGYan-Zhen,AssociateProfessor,DepartmentofFoodScience,CollegeofArtandApplication,BeijingUnionUniversity,No.197,BeituchengWestRoad,HaidianDistrict,Beijing100191,China.E-mail:[e-mail]陆建平,张静,张艳贞*(,100191)摘要:,,,关键词:;;ThefunctionalactivitiesandapplicationofpolygonatumsibiricumpolysaccharidesLUJian-Ping,ZHANGJing,ZHANGYan-Zhen*(DepartmentofFoodScience,CollegeofArtandApplication,BeijingUnionUniversity,Beijing100191,China)ABSTRACT:Polyonatumsibiricumpolysaccharide(PSP)isanimportantfunctionalingredient.Itshowsvariousfunctionssuchasantioxidation,immunologicalregulation,antifatigue,antiviral,regulationofbloodglucoseandlipid,antibacterialandanti-inflammatory.Soithasagoodfutureinthefieldsoffoodandmedicine.Inthispaper,thebiologicalactivitiesandtheapplicationsofPSBinmedicalpreventionandtreatmentandtheprospectoffunctionalfoodweresystematicallysummarized.KEYWORDS:polygonatumsibiricumpolysaccharides;functionalactivity;application,,,[1,2][3],(Polygonatumsibiricumpolysaccha-ride,PSP),1黄精多糖的化学组成,,-,,,,[2](thin-layerchromatography,TLC)(nuclearmagneticresonance,NMR)2744(infraredspectroscopy,IR),αβ,2-6,13C-NMR135DEPT-NMR:Ⅰ4,β-(1→2),α,;Ⅱ,1→6,Ⅲ[1],[4]2黄精多糖的功能活性2.1抗氧化与抗衰老,,,[5-13]2.1.1抗脂质过氧化(malondialchehyche,MDA),PSPMDA,[7][8]2.1.2抗自由基DNA,,,,[9]。2.1.3调节氧化防御相关酶活性,(superoxidedismutase,SOD),(glutathioneperoxidase,GSH-Px),,,SODGSH-PxNa+-K+-ATPCa2+-ATPSODGSH-Px,Na+-K+-ATPCa2+-ATP,Ca2+[10],PSPSODGSH-Px,(lipidperoxide,LPO)(lipofuscin,LF)B(B-typemonoamineoxidase,MAO-B)[7,11]DNA(mtDNA),DNA,Ⅰ+ⅡⅢDNAγmRNA,,DNAγmRNA,Ⅰ+ⅡⅢ[12],,,,,[13]2.2免疫调节T,(Cy),(DTH),CyDTH,[14]PSW3A-1()PSW4APSW5B()[4]2.3抗肿瘤,H22S180(MCF-27)HepsEac,-[15,16],,1,:275[16]2.4调节血糖和血脂(TG)(TC),[17](ALX),,NONOS,TGTC,NONOS[18](STZ)STZ,,,Caspase3[19]2.5抗疲劳,,,,[20][21]2.6抗病毒,,Vero,1(Stoker)2(333Sav),MTT,Vero,,,[22]2.7抑菌和抗炎,,(P0.01),[3]3黄精多糖的应用前景,,,,,3.1黄精多糖在疾病预防与辅助治疗方面的应用前景3.1.1预防和治疗动脉粥样硬化,(AS),ASASAS,ASLDL-CHDL-C[23]AS,C-(CRP),CRPASASIL-6CRP,,ASAS[24]3.1.2预防和治疗老年性痴呆(Alzheimer'sdisease,AD),AD,AD,,APPCA1,,[9];MorrisAD,AD[25]27643.1.3治疗帕金森病(Parkinsondisease,PD),,6-PDPD,-γ(peroxisomeproliferator-activatedreceptor-γ,PPAR-γ),,PD,,(ADPD)[26]3.1.4改善抑郁,5-(5-hydroxytryptamine,5-HT)(dopamine,DA)(norep-inephrine,NE)-2(interleukin-2,IL-2),,,,(5-HTDA)IL-2,,[27]3.2黄精多糖在功能食品中的应用前景,“,;,,;,;,”,“”“”[5-13],,[28],,,;,,[29],,,,,,,,[30],[31],,“”,(:2004100603715);“”,(:2012101172167)[30](031329128)(:2005100744915)[32],,,,(:2003101226488),,,,,,,,,,,,,参考文献[1].[D].,2011.FangY.SeparationandstructuralanalysisofPolygonatumpoly-saccharidesandoligosaccharides[D].JiangnanUniversity,2011.1,:277[2],.[J].,2009,13(7):719–722.ZhuLL,XuWP.ResearchprogressofpharmacologicaleffectsandextractionmethodsofPolygonatumtotalsaponinsandpoly-saccharides[J].AnhuiMedPharmJ,2009,13(7):719-722.[3],,.[J].(),2010,33(3):272–275.ZhengCY,WangHF,ZhangTT.StudiesontheAnti-MicromialandAnti-InflammatoryActivitiesofPolygonatumCyrtonemaHua.Polysaccharides[J].JAnhuiNormUniv(NatSci),2010,33(3):272-275.[4],,.[J].,2006,37(8):1132–1134.LiuL,ChengY,DongQ.PolysaccharidefromPolygonatumsi-biricumandtheirimmunologicalactivities[J].ChinTraditHerbDrugs,2006,37(8):1132-1134.[5],.[J].,2011,22(3):623–624.ChenG,YanSH.ProtectiveeffectsofPolygonatumpolysaccha-rideonvascularendothelialcellinjuryinducedbyhydrogenpe-roxide[J].LishizhenMedMaterMedRes,2011,22(3):623-624.[6],,.[J].,2011,26(7):1630–1632.WenZ,HuGZ,YuF.Studytheinterventionofpolygonatumsi-biricumpolysaccharidesonproliferationofbonemarrowstromalcellsinhibitedbyVCR[J].ChinaJTCMPharm,2011,26(7):1630-1632.[7],,,.[J].,2011,49(5):6,11.YuQW,WuXL,ZhangGX,etal.AntioxidanteffectsofPoly-gonatumpolysaccharideinrats[J].ChinaModDoct,2011,49(5):6,11.[8],,,./[J].,2008,19(4):959–960.WenDJ,ChenGD,ZhuYC,etal.ProtectioneffectsofPolygo-natumextractonHypoxia/reoxygenationinjury[J].LishizhenMedMaterMedRes,2008,19(4):959-960.[9],,,.APPCA1[J].,2010,16(10):165–167.ChengW,TianW,LiYY,etal.EffectsofPolygonapo-lysaccharoseuponSynapseStructureinHippocampus’sCAIRe-gionofAPPTransgenicMice[J].ChinJExpTraditMedFormu-lae,2010,16(10):165–167.[10]D-[J].,20087(2):137–138.WangAM.Anti-agingeffectsofPolygonatumuponD-galactoseinducedagingmice[J].JChangchunUnivTraditChinMed,2008,7(2):137-138.[11].[J].,2010,25(7):1259–1261.LiuP.EffectofPolygonatumsibiricmupolysaccharidesonen-zymesrelatedtotheagingofagedRats[J]WestChinaMedJ,2010,25(7):1259-1261.[12],,.DNAγ[J].,2009,8(16):2076–2077.ZhangT,JinY,WeiXD.EffectsofPolygonatumpolysaccharideonrespiratorychainenzymesoflivermitochondrialandDNA-γpolymeraseinagingmouse[J]JChinGerontol,2009,8(16):2076-2077.[13].[J].,2005,22(7):894–895.LiYY.ThechangeoftelomeraseactivityinagingmicetissueandtheinterferenceofPlyonatumsibiricum[J].JClinRes,2005,22(7):894-895.[14],,,.[J].,2006,12(7):42–45.ZhangTT,XiaXK,Che