EPA-DHA的营养功能及其产品安全性分析

ModernFoodScienceandTechnologyVol.22No.3(89)180EPADHAEPADHANutritiveFunctionandSafetyAnalysisofEPAandDHAHaoYing,WangZhi-he(FoodCollege,ShanghaiFisheriesUniversity,Shanghai,200090)Abstract:Thispaperdescribesthestructurecharacteristicandthemetabolizeruleofthetwopolyunsaturatedfattyacids,anddescribestheirnourishmentfunctionandmechanismforthehumanhealth.Atthesametimes,thispaperanalysestheediblesecurityandexistingproblemsofthecorrelationproducts.Keywords:EPA;DHA;Polyunsaturatedfattyacids;SecurityEicosapentaenoicAcidEPA)(DocosahexaenoicAcidDHA)n-3omega3polyunsaturatedfattyacidsn-3PUFA[1,2]EPADHADHAEPADHAEPADHAEPADHAEPA1-2[3]EPADHADHAEPA1.1EPADHAEPA520DHA622EPADHAn-3[4]EPADHAEPADHA[5]EPADHAα-α-LNAn-3n-n-36C25n-3n-6[4,6]EPA(PGS)(LTS)DHAPGSDHAPGS[5]1.2EPADHA1.2.1(Ischenicheartdisease-IHD)IHD[7]EPADHAModernFoodScienceandTechnologyVol.22No.3(89)181[8,9]Umanan40[10][10]EPADHA[11]EPA[12]EPA6-[12,13]EPADHAEPADHA(AA)(Desaturase)(Cytooxygenase)AA(TXA2)[5,14]EPAPGsDHAAAPGI2TXA2[5]EPADHA[15,16]EPADHA1.2.2[10]EPADHAEPADHAEPADHA[16]EPADHAEPADHA[9,17]PGE2DHAPGPGE2[18]ChapkinEPADHAEPADHA[18]DHADustinDHADHAEPADHA[5]DHADHA[19]DHA[16]DHADHA1.2.3EPADHA[10]EPAEPADHA5-B5(LTB5)LTB4LTB5LTB4LTB5LTB41/10~1/30[16]EPALTB5LTB4n-3[20]ModernFoodScienceandTechnologyVol.22No.3(89)182LTSRAF[5,20]DHALTSDHA1.2.4DHA10[5]DHAG.J.An.dersonEPADHADHADHADHA[21]DHADHA[22]DHADHA[5]DHA1.3EPADHA1.3.1EPADHAEPADHA1.3.2EPADHA[4,23]EEEPADHADHA[4]2.1EPADHA“”[24](FDA)FDA340g170g2.2ISOModernFoodScienceandTechnologyVol.22No.3(89)1832.3200498FDAEPADHAn-319962000SC/T35022000EPADHAn-3[1]SinclairAJ.Thegoodoil:omega3polyunsaturatedfattyacids[J].Today’sLifeScience,1991,3(8):l8.[2].DHAEPA[J].,2002,24(5):71-73[3].DHAEPA[J].,2003,39(3):44-47[4].EPADHA[J].,1994,14(6):56-60[5].DHAEPA[J].,2005,20(3):118-121[6]KinscllaJ.E.SeafoodsandFishoilinHumanHealthanddisease[J].MarcelDekker,INC,N.Y.1987,1-39[7]AnnetteDickinson,BenefitsofLongChainOmega-3FattyAcids(EPA,DHA):HelpProtectAgainstHeartDisease[J].CouncilforResponsibleNutrition,2002(6)[8]DyerbergJ.,etal.,Eicosapentae-noicacidandpreventionofthrombosisandatherosclerosis[J]Lancet,1978(2):117-119[9].DHAEPA[J].,1998,18(4):48-62[10]DyerbergJ.ObservationonpopulationsinGreenlandandDenmark,in“NutritionalEvaluationofLongChainFattyAcidsinFish.SubsidiaryHarcourtBraceJovanovichPublisher,London,1982,245-262[11].[J].1992,14(1):17-22[12].α-EPADHA.[J],1988,19(2):110-113[13]..[J],1979,10(4):338-344[14].(EPADHA)[J].,1985,(11):55-63[15].[J].,1984,12,(4):9-14[16].[J].,1998,19(3):29-35[17].DHAEPA[J].,1997,9(1):65-70[18].DHAEPA[J].,2004,10(2):188-121[19].DHAEPA[J].,1995-2005,14(1):51-55[20].n-3[J].,2004,24(6):5l7-5l[21].[J].,1996,17(10):10-15[22].[J].,2002,(3):67-70[23]W.J.Kort,eta1ProstaglandinsLeukotrienesEssent[J].FattyAcids,1992,45(4):319-327[24].[J].,2004,(9):12-13