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2920074241-47WORLDSCI2TECHR&DVol.29Apr.2007No.2pp.41-47(,266042):,,,,,,,,,,,,:ToxicologicalCharacteristicsandBiomarkersofPolycyclicAromaticHydrocarbons(PAHs)KUANGShaopingSUNDongya(CollegeofChemistryandMolecularEngineering,QingdaoUniversityofScienceandTechnology,Qingdao266042)Abstract:Polycyclicaromatichydrocarbons(PAHs),whichmainlycomefromtheincompletecombustionprocessesofhy2drocarbons,arewidespreadenvironmentalpollutantsinatmosphere,waterandsoils.BecausePAHsarehydrophobic,carcino2genic,teratogenic,mutagenicanddisbiodegradable,theyareregardedasthemajorrepresentationofpersistentorganicpollu2tants(POPs).Atpresent,studiesonthetoxicologyofPAHshavebecomeoneofthehotspotsinenvironmentalscience.StudiesonthetoxicologyofPAHsfocusontheabsorption,distribution,excretionandmetabolictransformationofPAHsandtheirdegradationandtransformationinvivo.ThetoxicologyofPAHselucidatesvariousconditionsandmechanismsofthee2mergence,developmentandabatementoftoxicationtohuman.Biomarkersareessentialcontentintheassessmentoforganicpollutants,andtheycanexplorethemonitoringindexfromPAHsimpairtohumanhealth.Inordertodetectenvironmentalpollutantsearlyandtotakemeasurestoeliminateit,biomarkersdetectoriginalbiologicalalterationafteritactonbodybythemostsensitivedetectingmeans.Inthispaper,thesource,thepropertyandthedistributionofPAHsispresented,andtheadvancesinresearchingonthetoxicologyofPAHsarereviewed.ProspectsforresearchonthetoxicologyofPAHsarealsodiscussed1Keywords:PAHs,persistentorganicpollutants(POPs),toxiceffect,biomarker(PolycyclicAromaticHydrocar2bons,PAHs)[1],,;,,,,,,16,7[24]1,,-,Bap2007442[5],:(1),PAHs[6];(2),PAHs;(3),PAHs;(4)PAHs;(5)PAHsPAHs,,PAHs[7];(6),PAHs[8]200,PAHs,PAHs,:,PAHs,:[9]PAHs,20,[10]PAHs,,,,,PAHs,,PAHsPAHs,3,,,;,,,,,,,,311,,,70%90%,[11],,,PAHs,[12]3212%2516%,(2313%1610%)PAHs,,[13]PAHsPAHs((a),BaP)[14]1973,,BaP100m3011g,5%[15]20074(a)160/10,14PAHs(a)015[16]PAHs,[17]PAHs,,,,(),(),,12515/10[18]1Fig.1ThemolecularstructureofPAHs,[19]PAHs,,1M,E,L,K,49,,[20],64,13,(h)(l)(n)100%[2123],,-,,(SVM)FisherK-,SVM,SVM,312,,PAHs,,,(400800nm)(280400nm),[24]PAHs,,DNA,,,DNA,[25],PAHsPAHs,,Bertilsson[26],:,Katz[27]BaPBaP,,,PAHsPAHsPAHs,PAHs,313,PAHs,PAHsPAHs,:[28]PAHsOH-NO-3NO2-PAHsPAHsNO2-PAHs2007444[29];(NH2-PAHs)(NHAc-PAHs),,;,,2-(NF),Mollre[30],NF,,,DNAB[a]A(PAH),[31],,314PAHsTroisi[32],,,Burchiel[33],TBJe2drychowski[34]PAHsDetmar[35]PAHsHeudorf[8],15%,10%,20%,15%,25%,42%,60%,,P450[36]4:,,,,,,,DNAP450,411DNAPAHsDNA,DNA,,DNA[37]PAHs(AHH1EH1GST),DNA,,DNADNAPAHs-DNAPAHsDNA,,DNA,PAHs-DNADNA,DNA,Mumford[38]4PAHs,PAHsHO-PAHs,,PAHs,PAHs,,,8/108,DNA[39],DNA,PAHsDNA8-OHdG,-Marczynski[40]DNABag2chi[41],DNA,20074[42](PAHs),PAHs,,DNAPAHs,,PAHs,PAHsLarge[43],DNA,14d,DNA,PAH-DNA,,PAH-DNAPAH-DNA,412P450P450-(heme2thiolateprotein),(superfamily),,,,P4501A21B1P4501A1,P4501A11A21B1[44][45]P450,P450,,,[46],P450,(0200mg/L0100mg/L),P450,P450-,P450-[47](),P450,P450-,P450P450,,,,,,P450,P450,P450,P450,,413,PAHs,:(1),,,,PAHs,PAHs(2)PAHs,,,,PAHs(3)GC-MS-MSHPLCESRMNR,2007446:(1),;,,,,,(2),,,(3),,,DNA,DNA,DNA[1]TsaiWenTien,MiHsiaoHsuan,ChangYuanMing,etal.Polycyclicaromatichydrocarbons(PAHs)inbio2crudesfrominduction-heat2ingpyrolysisofbiomasswastes[J].BioresourceTechnology,2007,98:11331137[2]BaranS,BielinskaEJ,OleszczukP.Enzymaticactivityinanairfieldsoilpollutedwithpolycyclicaromatichydrocarbons(PAHs)[J].Geoderma,2004,118:221232[3]MariaBlasco,CeliaDomeno,CristinaNerin.UseofLichensasPollu2tionBiomonitorsinRemoteAreas:ComparisonofPAHsExtractedfromLichensandAtmosphericParticlesSampledinandAroundtheSomportTunnel(Pyrenees)[J].EnvironSciTechnol,2006,40:63846391[4]PatrykOleszczuk,StanislawBaran.Polycyclicaromatichydrocarbonscontentinshootsandleavesofwillow(salixviminalis)cultinatedonthesewagesludge-amendedsoil[J].Water,AirandSoilPollution,2005,168:91111[5]MaliszewskaKordybachB.Dissipationofpolycyclicaromatichydrocar2bonsinfreshlycontaminatedsoils-theeffectofsoilphysicochemicalpropertiesandaging[J].Water,AirandSoilPollution,2005,168:113128[6],,,.[a][J].,2006,19(1):9195[7]WieslawJedrychowski,AleksanderGalas,AgnieszkaPac,etal.Prena2talambientairexposuretopolycyclicaromatichydrocarbonsandtheoccurrenceofrespiratorysymptomsoverthefirstyearoflife[J].Eu2ropeanJournalofEpidemiology,2005,(20):775782[8]HeudorfU,SchumannM,AngererJ,ela1.Dermalandbronchialsymptomsinchildren:aretheycausedbyPAHcontainingparquetglueorbypassivesmoking?[J].IntArchOccupEnvironHealth,2005,78(8):655662[9]SunPing,PIerretteBlanchard,KennethABrice,etal.TrendsinPoly2cyclicAromaticHydrocarbonConcentrationsintheGreatLakesAt2mosphere[J].EnvironSciTechnol,2006,40:62216227[10],.PAHs[J].,2001,20(2):123125[11],.[J].,2004,4(30):5559[12],,.PAHs[J].,2005,25(2):262267[13]DanielPKNg,TanKarWai,ZhaoBin,etal.CYP1A1polymor2phismsandriskoflungcancerinnon-smokingChinesewomen:influenceofenvironmentaltobaccosmokeexposureandGSTM1/T1geneticvariation[J].CancerCausesandControl,2005,16:399405[14]