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[]100723949(2008)1621020757206-,(,510515)[],,,,,,,7,,240,SCI3990:(,1991);(,2002);(,2004)-(,2007)[];;;[],,B,,,[]R363[]A[]2008203211,80(atherosclerosis,As),As1999RossAsAs,As,,,As,(lowdensitylipoprotein,LDL)(oxidizedLDL,ox2LDL)[124]As,,[426]1[4,7211],As,AsO2-,O2-,O2-H2O2,H2O2OH,(myeloperoxidase,MPO)HOClO2-H2O2NADPHNO,/,,/(reducedformofnicotinamide2ademi2nedinucleotidephosphate,NADPH),1.1,,757CN4321262/R20081610NO,(1):,,O2-NO,(superoxidedismutase,SOD),SODGPxGPx,O2-(2):O2-H2O2,,Asox2LDL(tumornecrosisfactor,TNF),SOD(catalase,CAT)N2(N2acetylgalactosamine,NAC),,Anoikis,,,NACNADPH(diphenyleneio2donium,DPI)(3):,,,As11IL21TNFVCAM21(pyrrolidinedithiocarbamate,PDTC)NAC,VCAM21ICAM21NAC(4):,,As,,H2O2,(vascularendothelialgrouthfactor,VEGF),,,(1)(vascularsmoothmusclecell,VSMC):VSMC,,,AsVSMC(angiotensin,Ang)VSMCVSMCAngVSMCCATp22phox,,VSMCNADPH(plate2let2derivedgrowthfactor,PDGF)H2O2VSMC,H2O2,PDGFVSMCH2O2,VSMCCATNACDPIH2O2VSMC,CAT,(2)VSMC:VSMCPDGFVSMCCAT,PDGFVSMCNACDPIEb2selen,2Rac,NADPHO-2VSMCVSMC(3):(matrixmetalloproteinases,MMP)MMPVSMCMMP22Pro2MMP29MPOHOCl,MMP27,MMPMMPVSMC,MMP22mRNA,NADPH,1.2,NADPHNAD2PH,,NADPHNADPHNADPHb558,NADPHO2,O-2p22phoxgp91phoxp47phoxp67phox,GRacNADPH,NADPHNADPH,gp91phox(NOX2)NOX1NOX3NOX4NOX5NADPHgp91phoxNADPHNOX1NOX4gp91phox,p67phoxgp91phox,gp91phoxNADPHO-2O-2,As/NADPHO-2gp91phox,,NOX4,apoE(E-/-),p47pho,apoE-/-,,NADPHAsAsAsNADPH857ISSN100723949ChinJArterioscler,Vol16,No10,2008p22phox,Asp22phox,,p22phoxNOXgp91phoxp22phoxNOXAsp22phox,gp91phox,gp91phox,NOX4,NOX1NADPH,p22phoxox2LDL,,,p22phoxNADPHLDLNADPH,As,As,MMP,,,NADPH,,NO(NOS)NOO2-NOSL2,(tetrahydrobiopterin,BH4)NOL2BH4BH4,NOS,O2-apoE-/-eNOS,eNOSAseNOSapoE-/-AseNOS,NOO2-,BH4AsBH4BH4eNOSAs,NOSBH4,AsAsBH4BH4BH4BH4apoE-/-,NOSOONO,BH4,eNOSBH4MPO/H2O2/Cl-HOCl(NO2Cl)NO2,,32MPO,32,NO232,MPO,/,MPO(reactivenitrogenspecies,RNS),MPOMPO,H2O2HOClNO,NOMPOAsMPOLDL,AsMPO,MPO2[1,5,12218]2.1:AsAs,,,T,,,T,As,,,,,:,,,,,(acutecoronarysynthrome,ACS)?T,,,,:MMP,MMP,MMP,,(),Cystatins,LDL:,,LDLLDL,,As,,,957CN4321262/R20081610,VCAM21,VCAM21,,,,AsAs,As,LDL,,,,,:,As,Tollox2LDLox2LDL,,,AsToll,,,(dendriticcell,DC)TollDNAToll,60ox2LDLAsToll,,Toll,apoE-/-As2.2As,,(chron2icreactiveprotein,CRP)IL26IL28TNF2E,,,As,IL218,INFT,AsIL218,IL2181(plasminogenactivatorinhibitor21,PAI21)(tissueplasminogenactiva2tor,t2PA)PAI21,t2PAPAI21t2PA,,t2PA,,As,PAI21,PAI21MMP29,MMP29MMP29IL218,MMP29IL218AsMMP29,MMP,MMPMMP29MMPMMP,MMP29AsC(C2reactiveprotein,CRP)206,As,(INFIL21TNF)IL26,CRPIL26CRPCRP,CRPAsCRP,;,;;,CRPAs,,,,,CRP,ox2LDL,CRP2LDL,,CRP,,CRPAs067ISSN100723949ChinJArterioscler,Vol16,No10,20083B[7,19223]B(nuclearfactor2B,NF2B),TNFIL21NF2BTNFIL21TNFIL21NF2B,,,,,,,NF2B,NF2B,TNFIL21NF2B,NF2BNF2B,25NF2BNF2BNF2B,NF2B(5),NF2B3.1BAsNF2BAs,TNF2BRelA(p65),p50RelA,As,NF2B,,As,AsNF2B3.2BAsNF2B,,,,NF2B:As,Asp50/p105p65c2rel,TNFIL21TNFNF2BE2se2lectin5NF2BDNANF2BVCAM21E2selectinIL21IL26TF(tissuefactor)PAI21COX2iNOSIBIKK22TNFE2selectinVCAM21ICAM21IL26MCP21GroTF,IL21TNFNF2B,NF2B,As:As,ox2LDLHSPTox2LDL(HLADR)apoE-/-LDLLDLTDC,,,TDCAs,DCTCD402CD40TCD40DCDCT,IKK2NIK,DCIKK2IKK/:As,TNFIL26IL28MCP21NF2B,IBLPSTNFIL21IL26IL28,IL210IL211NF2B,,IKK22VEGF,LPSTNF2IL26IL28;CD40VEGFIKK22/,p50LPSLDL,TNF2,IL210IFN,MCP21IL21IL212,As,,IKK22TNF2IL26IL210,As,NF2B,,:,AsNF2BNF2B,Caspase(inhibitorofapoptosis,IAP)Bcl2Caspase,,,CaspaseIAP,NAIPcIAP21cIAP22XIAPSurvivinFas/CD95TNF1CaspaseTNF1DDTRADD167CN4321262/R20081610FADD,Procaspase28Procaspase210,Procaspases,Caspase,Pro2caspase23Procaspase,TRAF21/TRAF22c2IAP21cIAP22TNFFADDCaspaseTRAFs/IAPsIAPNF2BTRAFNF2BTNFIKKIBCaspase28IBIAPTNFcIAP22NF2B,NF2BMMPNF2B:,As,,TF,MMP,,,TFMMPNF2BTF,/a,,TFAs,TF,TFNF2B,NF2BChloromethyketoneTF,IBNF2BPDTCLPSPMATNFIL21TFIBIKK2TF/,TF,NF2B,MMP21MMP23MMP29,MMPNF2B,IBMMP21MMP23MMP213,TIMP21IL21NF2B,MMP21MMP23MMP29NF2B,CD40MMP21IBAsox2LDLMMP29,NF2BAP21[][1],.2[M].:,2007;2522287.[2]RossR.Atherosclerosis2aninflammationdisease[J].NewEnglJMed,1999,340(2):1152126.[3]ShishehborMH,HazenSL.Inflammatoryandoxidativemarkersinathero2sclerosis:relationshiptooutcome[J].CurrAtherosclerRep,2004,6(3):2432250.[4]StockerR,KeaneyJFJR.Roleofoxidativemodificationsinatherosclero2sis[J].PhsiolRev,2003,84:13812478.[5]AltmanR.Riskfactorincoronaryatherosclerosisinflammation:themeet2ingpoint[J].ThrombJ,2003,1(4):1211.[6]CerielloA,MotzE.Isoxidativestressthepathogenicmechanismunderly2inginsulinresistance,diabetes,andcardiovasculardisease?Thecommonsoilhypothesisrevisited[J].ArteriosclerThrombVascBiol,2004,24:8162823.[7]YokoyamaM.Oxidantstressandatherosclerosis[J].CurrentOpinPharmacol,2004,4:1102119.[8]TaniyamaY,GriendlingKK.Reactiveoxygenspeciesinthevasculaturemolecularandcellularmechanisms[J].Hypertension,2003,42:10752081.[9]HeerebeekLV,MeischiC,StookerW,etal.NADPHoxidasea(s):Newsource(s)ofreactiveoxygenspeciesinthevascularsystem[J]?JClinPathol,2002,55:5612568.[10]NambiV.Theuseofmyeloperoxidaseasariskmarkerforatherosclerosis[J].CurrAtherosclerRep,2005,7(2):1272131.[11]CathcartMK.RegulationofsuperoxideanionproductionbyNADPHoxi2daseinmonocytes/macrophagescontributiontoatherosclerosis[J].Ar2teriosclerThromb