晚期非酶糖基化终末产物AGEs及其临床意义

IL-13,IL-13,,IL-13,IL-13,,1ZurawskiGetal.ImmunolToday,1994;15(1):19~262NaseerTetal.AmJRespirCritCareMed,1997;155(3):845~8513DeFifeKMetal.JImmunol,1997;158(7):3385~33904DeWaalMalefytRelal.JImmunol,1993;151(11):6370~63815NaifHMetal.JImmunol,1997;158(1):501~5116MuzioMetal.Blood,1994;83(7):1738~17437BochnerBSetal.JImmunol,1995;154(2):799~8038Lebel-BinaySetal.EurJImmunol,1995;25(8):2340~23489SauraMetal.BiochemJ,1996;313(2):641~64610LakkisFGetal.Jasn,1993;4(3):61311DutraWOetal.ScandJImmunol,1997;45(1):74~8012LakkisFGetal.BiochemBiophysResCommun,1993;197(2):612~61813ObiriNetal.JBiolChem,1995;270(15):8797~880414PuriRKetal.Blood,1996;87(10):4333~4339晚期非酶糖基化终末产物(AGEs)及其临床意义上海医科大学华山医院肾内科(200040)郭晓敏综述陆福明审校(AGEs),,AGEs,(advancedglycosylationendproducts,AGEs),Alzheimer(),AGEs1AGEs,Maillard,,,:(pentosidine)pyrraline,AGEs[1]Maillard:¹(@e)(,)Schiff,,;ºSchiffAmadori,,;»Amadori,,3-DG,AGEsMaillardAGEs,AGEs[2],[7],Maillard;,AGEsAGEs[3]:¹;º;370nm,440nm;»,,,,(G);¼,;½,:,2AGEs2.1改变蛋白质的结构12156G,G,,,G,,,,,[4]G,[5]G,,[6]G,G,2.2影响脂质代谢,,LPLDLAGEsAGEs-LDLMakitaAGE-LDL,[7]LDLLDL,LDL,GEsLDL,[8],AGEs,,G,AGEs2.3修饰核酸,[9]DNA,G,,DNALEE6-,,AGE-DNA,[10]AGEs2.4通过AGEs受体导致损害2.4.1AGEsRadoffAGEs,9060KD,AGEs[11]AGEs,AGEs,AGEs[12]AGEs,TNF-@,IL-1[13],IGF-1,PDGF[14,15],,,PDGF,G,,,AGEs,,,,2.4.2AGEsPeakeAGEs[16]AGEs[17]AGE[18]AGEs,,,,AGEs,,[19]AGEs,,[20],AGEsNO,NO[21]G,[22],AGEsAGEs,,,2.4.3AGEs,GFREdward.YAGEs,AGEs[23]G,IVAGEs,[24]G5,AGEs50%,,[25]G,IVB1TGF-BmRNA,[26],AGEs,,2.4.4,TAGEs,1221998183AGEsAGEs,EGFAGEs3AGEs3.1肾功能与AGEs的关系AGEsAGEs,AGEs,,,AGEAGE,,AGEAGE[8];,AGE,,AGE[27]MakitaAGE,AGE(HMW-AGE,10kd),,HMW-AGE,AGE(LMW-AGE,[10kd)LMW-AGE,LMW-AGE)[27][28]3.2各种肾脏替代疗法对AGE水平的影响Ateshkadi:,AGE,CAPD[29]Odetti.P(pentosidine)AGE,,AGE,,;,[30]LMW-AGE33%,3.5LMW-AGE,,;,3[28]AGEs,AGEs[31];,AGEs,AGEs,,AGE[27],[28]3.3AGEs与腹透的相互影响AGEs[31],AGEs,,75~214mmol/L,CAPD,,,[32]CAPD,CAPD,,,[32],AGEsCAPD,CAPD,,[33],AGEs,,AGEs,,,AGEs,AGEsPBS,AGEs,AGEs3-DG,Maillard,AGEs[32],AGEs;LambAEGAGEs,AGE,[32]3.4AGEs与血透的相互影响AGEs[2],,B2-MGG,,,AGEs[34]AGE(DRA)DRA,,B2-MG;,B2-MGAGE[35]AGE-B2MG,TNF-@IL-1BTNF-@1L-1B,,,,,[15],AGEs12356,,,AGEs,,VitB6D-[36,37],,1Booth.AAetal.J-Biol-Chem.1997;272(9):5430~72Thorpe.SRetal.Drugs-Aging.1996;9(2):69~773ZMakitaetal.J-Biol-Chem.1992;267:5133~84Sensi.Metal.Diabetes-Res.1991;16(1):1~95JThomeetal.Life-Sci.1996;59(8);679~856SMruthintietal.Exp-Eye-Res.1996;62(5):505~107BucalaRetal.Proc-Natl-Acad-Sci-USA.1993;90(14):6434~88BucalaRetal.Proc-Natl-Acad-Sci-USA.1994;91:9441~59BucalaRetal.Proc-Natl-Acad-Sci-USA.1984;81:105~910LeeATetal.Proc-Natl-Acad-Sci-USA.1987;84:8311~411Radoff.Setal.Diabetes.39;1510~812M.Kirsteinetal.Proc-Natl-Acad-Sci-USA.1990;87:9010~413H.Vlassaraetal.Science.1988;240:154614Martina.Ketal.J-Clin-lnvest.1992;90:439~4615T.Mayataetal.J-Clin-lnvest.1994;93:521~816Peake.PWetal.Diabetes-Res-Clin-Pract.1989;11:109~1417SchmidtAMetal.J-Biol-Chem.1992;256(21):14987~9718Greten.Jetal.Nephrol-Dial-Transplant1996;11(5):786~9019C.Espositoetal.J-Exp-Med.1989;170:1387~140720Davies.MGetal.J-Surg-Res.1996;63(2):474~921BucalaRetal.J-Clin-lnvest.1991;87:432~822Kuzuya.Metal.Exp-Cell-Res.1996;226(2):336~4523Edward.Yetal.J-Exp-Med.1992;174:931~824Doi.Tetal.Proc-Natl-Acad-Sci-USA1992;89:2873~725H.Vlassaraetal.Proc-Natl-Acad-Sci-USA.1994;91:11704~826Makita.Zetal.N-Eng-J-Med.1991;325(12):836~4127Makita.Zetal.N-Eng-J-Med.1991;325(12):836~4128Makita.Zetal.Lancet.1994;343:1519~2229Ateshkadi.Aetal.Perit-Dial-Int1995;15(2):129~3330Odetti.Petal.Nephrol-Dial-Transplant.1995;10(11):2110~331Korbet.SMetal.Am-J-Kidney-Dis.1993;22(4):588~9132Lamb.EJetal.Kidney-Int.1995Jun;47(6):1768~7433Masaaki.Netal.Kidney-Int.1997;51(4):1170~8134MayataTetal.Kidney-Int.1996;50:1303~935TNiwaetal.Kidney-Int.1996;50:1303~936MKhatamietal.Life-Sci.1988;43:1725~3137MSensietal.Diabetologia1993;36:797~801尿酸性肾病的研究现状南京军区福州总医院(350001)余英豪综述谢福安审校,(U-AN)UAN,UAN,(uricacidnephropathy,UAN)UAN,,,UAN1,2/3\357Lmol/L(6mg/dl),1241998183