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MassBiotech2010ACHIEVINGGLOBALLEADERSHIPINTHELIFE-SCIENCESECONOMYCopyright2002,theMassachusettsBiotechnologyCouncil,TheBostonConsultingGroup,AllRightsReserved3Massachusettscanseizetheopportunitytoachievegloballeadershipinthelife-scienceseconomy.Thebiotechnologyindustrywillplayacentralroleinenhancinghumanhealthwhilefuelingeconomicgrowth.Togetherwecanbesuccessfulincontinuingscientificexcellenceandcreatingnearly100,000newjobsby2010.MassBiotech2010:AchievingGlobalLeadershipintheLife-SciencesEconomyistheproductofathree-monthstudyinvolvingrepresentativesfromover100diversegroupsincludingbiotechnologycompanies;universitiesandacademicmedicalcenters;pharmaceuticalcompanies;andfederal,stateandlocalgovernmentleaders.ThereportarticulatesavisionfortheMassachusettsbiotechnologyindustryandthebroaderlife-scienceseconomiccluster.Itidentifiesthemainchallengesandpresentsadetailedcalltoaction—forMassachusettspolicymakersandforthelife-sciencescommunity.Wethankthemanyindividualswhogavetheirtime,energy,andideastocreateareportwithbothvisionanddepth.WeacknowledgethesignificantcontributionsofthemembersoftheMBCboard,manyofwhomservedasleadersonthesteeringcommitteeandontheninetopicteams;TheBostonConsultingGroupforanalyticrigorandprofessionalisminconductingresearch,coordinatinginter-views,andwritingthefinalreport;andtheleadersofmajorlife-sciencesorganizationswhoprovid-edtheirperspectivesonbiotechnologyanditsroleintheMassachusettslife-scienceseconomy.AllindividualsarelistedbynameinAppendixIIofthereport(startingonp.59).Toachievethevisionby2010,Massachusettspolicymakersandbiotech,academic,andmedicallead-ersmustworktogether.TheMassachusettsBiotechnologyCounciliscommittedtothefutureoftheCommonwealth’slife-scienceseconomyandstandsreadytomakethevisionareality.JoshuaBogerChairmanandCEO,VertexPharmaceuticals,Inc.GarenBohlinPresidentandCEO,SyntonixPharmaceuticals,Inc.L.PatrickGageConsultant,ImmediatePastPresident,WyethResearchVaughnKailianViceChairperson,MillenniumPharmaceuticals,Inc.MarkLevinCEO,MilleniumPharmaceuticals,Inc.DavidMcLachlanSeniorAdvisor,GenzymeCorporationJamesMullenChairmanandCEO,Biogen,Inc.HansNilssonVicePresident,SiteGeneralManager,AstraZenecaR&DBostonRichardPopsCEO,Alkermes,Inc.UnaRyanPresidentandCEO,AvantImmunotherapeutics,Inc.HenriTermeerChairman,President,andCEO,GenzymeCorporationMarkTrusheimPresidentandCEO,CantataPharmaceuticals,Inc.FOREWORDJaniceBourquePresidentandCEO,MassachusettsBiotechnologyCouncilCynthiaFisherChair,MassachusettsBiotechnologyCouncil;CEO,BioMed20/20Technologies,Inc.MassBiotech2010ABOUTTHEREPORTMassBiotech2010:AchievingGlobalLeadershipintheLife-SciencesEconomyisajointreportoftheMassachusettsBiotechnologyCouncil(MBC)andTheBostonConsultingGroup(BCG).ABCGteam,headedbyDavidMathesonandMartinB.Silverstein,M.D.,con-ductedtheresearch,coordinatedtheinterviews,andcapturedtheideasandrecom-mendationsinthereport.Mr.MathesonandDr.Silversteinareseniorvicepresidentsinthefirm’sBostonofficeandleadersinthefirm’sglobalhealthcarepractice.BCGconsultantsRobertHoward,JeanineKellyMurphy,FabricePaublant,VikasTaneja,andBrookeWinklemadeimportantcontributionstotheproject.45MassBiotech2010CONTENTSExecutiveSummary....................................................6OurVision..........................................................8TenThingsStateGovernmentCanDoImmediately............................9Introduction........................................................11BiotechnologyandItsRoleintheMassachusettsEconomy.....................14ThePublicBenefitsofBiotechnology.....................................15Massachusetts“Teenage”Biotechs:HighPotential,BigVulnerabilities............21ModelingBiotech’sJob-CreationPotential.................................22TheRaceforRegionalAdvantage........................................24California:WorkingtoPreserveGlobalLeadership...........................26NorthCarolina:AimingfortheTop.......................................28MaintainingWorld-ClassResearchandInnovation............................29MovingDowntheDrug-DevelopmentValueChain............................31MakingItinMassachusetts:TheWyethStory...............................32LeveragingtheLife-SciencesEconomicCluster..............................35LessonsfromRoute128..............................................36TheRoleofStateGovernment...........................................38BESTinBIOTECH:APilotProjectforTrainingBiomanufacturingTechnicians........42TheRoleoftheLife-SciencesCommunity...................................44Summary...........................................................47AppendicesSpecificRecommendationsoftheMBCTopicTeams..........................49MassBiotech2010Stakeholders.........................................59MassBiotech2010Aftermorethantwodecadesofinnovationandinvestment,theMassachusettsbiotechnologyindustryispoisedonthethresholdofaneweraofgrowth.BreakthroughsinbasicscienceatMassachusettsuniversitiesandacademicmedicalcentersaregivingbirthtoadynamiclife-scienceseconomyandmakingthestateamagnetforpublicandprivateinve