Microfluidics

ADIVISIONOFMicrofluidicsDivisionNewton,MA(OTCBB:MFIC)ADIVISIONOFLaboratorytoFullProductionHighShearFluidProcessorsADIVISIONOFWhatIndustriesDoWeServe?•Biotech•Pharmaceutical•Chemical•PersonalCareProducts•FoodADIVISIONOFApplications-ThingsWeDoBest•Particlesizereduction(deagglomeration)•Createstablemicroemulsions•Createstablemicrodispersions•Createnanoparticles(MMR)•Celldisruption•Microencapsulation(liposomes)ADIVISIONOFPrincipleofOperationInletReservoirProductIntensifierPumpPressuresto40,000psiPressureGaugePatentedInteractionChamberCoolingJacketOutletADIVISIONOFHighPressureInletP1HighShearZoneHighImpactZoneLowPressureOutletP2P1InteractionChamberZTypeSingleSlotADIVISIONOFHighPressureInletP1HighPressureInletP1LowPressureOutletP2HighShearZoneHighEnergyImpactZoneHighShearZoneP1P1InteractionChamberYTypeSingleSlotADIVISIONOFInteractionChamberMinimumDimensionbaADIVISIONOFPrimaryForcesShear:Thedeformationoffluidscausedbyinducingadifferentialvelocity.Impact:Theforceofacollision.ADIVISIONOFVmaxVwall.004.002ADIVISIONOFIfVelocityMaximum(Vmax)=8000IN/SECVelocityatWall(Vwall)=0ThenAverageShear=8000IN/SEC.002IN=4,000,000X1SECOR4,000,000SEC-1(inverseseconds)VmaxVwall.004.002ADIVISIONOF450400350300250200150500010,00015,00020,0005.45.74.33.0Pressure(psi)Flow(ml/min)Averageshearsec-1millions500F20YIXCw/H30ZAPMAverageflowonM-110YMinimumpassagedimension-75µ=.003Averageshearper100ml/min=1.2millionsec-1ADIVISIONOF6005004003002001000500010,00015,00020,00025,00030,00035,00040,0009.5108.88.0Pressure(psi)Flow(ml/min)G10ZIXCAverageflowonM-140KMinimumpassagedimension-87µ=.0035(1humanhair)Averageshearper100ml/min=1.7millionsec-1Averageshearsec-1millions6.54.87.23.5ADIVISIONOFShearRatesForVariousTechnologiesFromChemicalEngineering,August1998Shear1/sec10,000,000AgitatorSawtooth-bladeClosed-rotorRotor-statorColloidMillHomogenizerMicrofluidizer®Processor100,000300,000500,000700,000ADIVISIONOFChemicalMaterialsProcessingDataSheetADIVISIONOFPharmaceuticalMaterialsProcessingDataSheetADIVISIONOFPharmaceuticalMaterialsProcessingDataSheetADIVISIONOFPharmaceuticalMaterialsProcessingDataSheetADIVISIONOFPersonalCareMaterialsProcessingDataSheetADIVISIONOFPersonalCareMaterialsProcessingDataSheetADIVISIONOFPharmaceutical/BiotechMaterialsProcessingDataSheetADIVISIONOFPharmaceutical/BiotechMaterialsProcessingDataSheetADIVISIONOFFoodMaterialsProcessingDataSheetADIVISIONOFFoodMaterialsProcessingDataSheetADIVISIONOFInksMaterialsProcessingDataSheetADIVISIONOFM-110SM-110YHC-5000M-110LHC-2000HC-8000LaboratoryEquipmentADIVISIONOFLaboratoryEquipmentM-110EHMicrofluidizer®ProcessorADIVISIONOFLaboratoryEquipmentM-140KMicrofluidizer®processorADIVISIONOFAdvantagesoftheInteractionChamber•Fixedgeometry-nomovingparts•Longwearing-ceramicordiamond•Guaranteedscaleup-labtoproduction•Sanitary-steaminplace•Clean-in-place-nodisassemblyADIVISIONOFGuaranteedScale-upADIVISIONOFInteractionChamberZTypeSingleSlotHighPressureInletP1HighShearZoneHighImpactZoneLowPressureOutletP2P1InletDischargeWallSlotADIVISIONOFInteractionChamberZTypeMulti-Slotted™(forscaleup)HighPressureInletP1HighShearZonesHighImpactZoneLowPressureOutletP2P1P1P1P1ADIVISIONOFInteractionChamberYTypeMulti-Slotted™(forscaleup)HighPressureInletP1HighShearZonesHighPressureInletP1LowPressureOutletP2HighShearZonesHighEnergyImpactZoneP1P1P1P1ADIVISIONOFPilotandProductionM-210EHSeriesM-610EHSeriesM-700SeriesADIVISIONOFM-700MicrofluidizerProcessorwithOptionalWheelsNotes:1.6dia.Sanitary(polyolefin)wheelswithstainlesssteelcastors2.AllwheelsareswiveltypewithlocksADIVISIONOFM-710MicrofluidizerProcessorADIVISIONOFM-710MicrofluidizerProcessorADIVISIONOF100HPM-7101.BasicdesignunchangedfromtheM-7250synchronousunit.2.Availablein:•10,000psi8gpmnominaltotalflow•20,000psi4gpm•30,000psi3gpm•40,000psi2gpm3.Nominal25strokesperminute(percylinder).4.Designedformaximumdrainability.5.Processplungertobeceramic(Zirconia).6.AlloptionsofferedoncurrentM-700unitsareavailable.ADIVISIONOFM-700SplitSystemADIVISIONOFContainmentUnitADIVISIONOFUltraCleanInPlace(UCIP)ProductFlowUCIPFlowADIVISIONOFSteamSterility3Levels:•Basic,forM-210Series•Level1,forM-210&M-700Series•Level2,forM-210&M-700SeriesADIVISIONOFSteamSterilityProprietarySteamableHighPressureDiaphragmValveADIVISIONOFAdvancedDevelopmentWorkADIVISIONOFSingleActingIntensifierPumpTPPowerStrokeSuctionStrokeProductInProductOutADIVISIONOFIXCAPMOutletcheckvalveInletcheckvalveProductinletIntensifierPumpBi-directionalIntensifierPumpSchematicADIVISIONOFTP60-100%PressureProfileBi-directionalIntensifierPumpADIVISIONOFM-7250&M-710SynchronousSystemsPAPMIXCIXCAPMProductOutSingleActingIntensifierSingleActingIntensifierAirPilotValveAirPumpAirSwitchAirSwitchTohydraulicdirectionalvalveADIVISIONOFPressureProfileM-7250&M-710SynchronousSystemsTP60-100%ADIVISIONOF•Lessvariationinpressureswingshouldreducefatiguefailures=longerlife•Customer’sproductseesmoreuniformpressure=moreuniformresults•Lesspiping,lesspartstoreplaceAdvantagesofSynchronizedOperationADIVISIONOFTheIdealPumpTPPressureTQFlowADIVISIONOFM-7250ConstantPressureSyste