基因治疗及基因治疗产品的质量控制_姜典财

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1241142CnJBid1,vol.14.No.2(,1(XJ050(,)(D),,,119,(ADA)[l1,,,,,(Nnl),,,,,[zJ,2,[,J:1.:(),,,,,,,2.:,,DNA,,,,,1.,,,,,,2.,,,,3.,,,,[],11No3643735Nb%073531303.llco,101.95.43015306.93381L0170.LLS0,0.4.5.6.0.0.L1(424121158171DNA/RNA12176I11330,6l1022400.1214,012.41021.,,,AAV,,,,,,,,2.DNA,:;,,2,,,,,,DOI10.13200/j.cjb.2001.02.124.jiangdc.0241142JBid1,vol.14..21252(P)(ASGp)PH,HUH.7,,,Wu198719881115;,13;;OUIyr,1PL,oL,BiG2,BNLCl,2,7n12;Hae,13;d~,13;Md,1;W15;,1PL,Pmta.,PEL,,pr,FMJJ.,1,MRC5,,CFTNll3R3,,,,,CEIDBi~,O.,19);W,19);e,19);,,13;,17PLPLOLPL2(FGF2)FG(FGFRGD,HCP5H,19);R~Ik,1B16BNK,,S,1KB,11a,C2,SW,OV,(2,,,C,nJ,15;G.d,1E,15;Cten,13;Yin,1He,18;Hart,15I,d,1;D.b,1Qr-cIrO-ar-PLHG2,,15nTnC.P~A,BdTnl,ll()3,K,Hd,Cl,,,,b,15Ba,1;R.,15PLPLT,1AndCJud,,CEM,n,B,15;17;,R,18;Dt,17Md,i,15PEI,.HELPLPLPLPLCD3CDll7MOe,TFI,.,1;~,18NA,9,On,1;O,1PLPLPLECFR12,nCdCDll7EGF,EGF,...nI,17,d,12PLC1,17.,.1,B,Cd,1;ddl,1R,,,,1;Rojand,11262001142nJBiZcol,vbl.14.NoZ1.[,,6],,,,,(AAV),2.,,3.DNA,,,,,t,,1.[v]PCRDNA,DNA2.,,3.[s],,4.,,,,,,,5.[9],,,L,RO)FDAIi,,1Pf1)l,,(MDI)106.,,,7.DNA,lo],DNA,DA,,%8.DNA101DNA,,DNA,g(),10g()9.,,10.(RNAK)(),101,,,,l]..,l5,75(9):517.2elwF.IGOley.i~,1,:.3S~sR,A.Inn.:abi-lyvepninto~.i~,1,5:19.4yS.Invog.i...lhu.1dorJbGe,15,6:185.5T.Gedle~:3cid,,.rRes,l7,17(3A):1471.[6KixH.hg,etr,inthavitr:ty6plifvey.1~C.lb,19i,7:1.7,..,1,27(1):9...,l,,26(3):87.[9]gwW.DIn..1mPcR.Biq,1,is:444.10,.DNA.,1),26(6)3.(18)

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