熊去氧胆酸的新合成路线和方法的研究

16Vol.16,No.220002NATURALSCIENCESJOURNALOFHARBINNORMALUNIVERSITY(),,,Benkeser,,,;,,,,50à65à.:;;;:O6213+3:2000-01-06:(1949),(),,,[1],,.,.[2,3],,,;,,,,,.11.1,.,.,..1.2Jones,,:[4,5],Benkeser,,.,,.22.1:.0.7à,80à.,,,,0.8à,90à.,,50à65à.,.2.2(1):3,7,24-3,7,24--12-3,7,24--12-(2):,,,,..0720002.3:M.P.ööö%202+57.07100198202+53+57.0798.5200204+59+6298.5:,,,,.,M.P.1.1990,8102LidaT.etal.,J.Org.Chem.1982,47,29663Macclonald,I.A.etal.Appl.EnvironMicrobiol.,1982,44,11874..B,1991,7,6805.,1990,48,99ANEWPROCESSANDMETHODOFSYNTHESIZINGURSODEOXYCHOLICACIDLiuXiangyunMoXinLiuXiaorui(HarbinNormalUniversity)ABSTRACTThepreviousprocessofsynthesizingursodeoxycholicacidisverycomplexandtheyieldisverylow.First,cholicacidisextractedfrombileofcattleandsheepandconvertedtochenodeoxycholicacidthroughseveralcomplexreactions.Second,thecarboxylicgroupisprotectedbymethylesterazationandthentheprotectedchenodeoxycholicacidisconvertedtomethylursodeoxycholatebyhydrogenizationwithbenkeserreaction.Last,ursodeoxycholicacidisobtainedbydemethylestertreatment.Thenewsyntheticprocessisthatchenodeoxycholicacidisdirectlyextractedandseparatedfrombileofchickenandisreducedtoursodeoxycholicacidbyhydrogenizingwithahighstereospecificcatalyst.Thesyntheticprocessisnotonlygreatlysimplifiedandcostisreduced,butthecomprehensiveconversionrateisincreasedfromprevious50percenttonowover65percent.Keywords:Cholicacid;Chenodeoxycholicacid;Highstereospecificcatalyst;Ursodeoxycholicacid172