20多巴胺的自聚_附着行为与膜表面功能化_徐又一

31　3　　　　　Vol.31　No.320116MEMBRANESCIENCEANDTECHNOLOGYJun.2011多巴胺的自聚-附着行为与膜表面功能化徐又一＊,蒋金泓,朱利平,朱宝库(,,,310027)　:多巴胺(dopamine)是一种生物神经递质,在水溶液条件下,它能在溶解氧的作用下发生氧化-交联反应,形成强力附着于固体材料表面的聚多巴胺复合薄层.基于多巴胺的这一特性,近年来膜技术研究者们通过多巴胺在固体基膜上的自聚-复合,对膜进行表面改性,并以具有反应活性的聚多巴胺复合层为平台,对膜进行进一步的表面修饰,实现膜的功能化.文章论述了多巴胺在膜表面修饰与功能化方面的研究进展,应用领域包括超/微滤膜、生物医用膜以及渗透汽化膜等.:多巴胺;多巴;儿茶酚衍生物;功能化;仿生;表面改性:TQ028.8　　:A　　:1007-8924(2011)03-0032-07　　,.,,,,(、).,,.,.;、、、.、、.,、.,,3,4-(L-DOPA,L-)3,4-(dopamine,),、、、、,[1-3].,,-.,-.1　多巴胺的超强黏附行为及其原理,,[4].(musseladhesiveproteins,MAPs),,.,MAPsMfp-5(mytilusfootpro-tein5),30%L-15%(lysine),MAPs[3,5,6].L-,L-,Mfp:2010-12-31:“973”(2009CB623402);(50803054);(Y4100204):(1945-),,,,.＊〈[e-mail]〉DOI:10.16159/j.cnki.issn1007-8924.2011.03.007　3:-·33　　　·　-5,[2].　　,,.,,,(1)[7,8].,,,-,[1,2].1　Fig.1　Schemefordopaminecross-linkinginaqueoussolution2　多巴胺自聚-复合在表面改性及功能化方面的应用2.1　,-,.,(2).,,,,,.2　Fig.2　Schematicrepresentationforsurfacemodificationofsolidmaterialsbydopamineaqueoussolution　　Lee[2]2g/L(pH8.5)-,、、、,24h50nm.Xi[9](PE)、(PVDF)(PTFE),,.Ku[10]-PE、PTFE,MC3T3-E1.Yu[11]304,.Li[12](PSF)-,PSF.Pan[13]PSF,PSF.Kang[14](AAO),AAO,AAO(3).Yu[15],,、pH,(4).　·34　　　·《》3031　(a)-(PDMS);(b)-90°180°[14]3　Fig.3　Micropatterningofsuperhydrophobicsurfacesandwettingproperties2.2　,-,.,,,.(a)pH-“/”;(b)pH[15]4　Fig.4　Thesuggestedstructureofpolydopamine2.2.1　.,,(—SH)、(—NH2)(—NH—)(Michaeladdition)(Schiffbasereac-tion),(5)[2].5　Fig.5　Surfacemodificationofmaterialsbydopaminecoatingandsubsequentimmobilizationoffunctionalmolecules　　-—SH、—NH2,(self-assembledmonolayers,SAMs).[16]-PTFE,CGREDVDY,PTFE.—SH、—NH2—NH—[(PEG)],,、[2,3,17].McCloskey[18]PVDF、PSF(PA)PEG,(BSA),.Jiang[19]PE,,.2.2.2　,.,,　3:-·35　　　·　,.Li[20]-,2-(BIBB),(ATRP)(PAAc),pH(6).6　ATRP[20]Fig.6　SchematicillustrationoftheATRPofAAconpolydopaminefunctionalizednylonmembraneinaqueoussolutions2.2.3　,.,,[1,2,4].Liao[21,22](PI),PI,PI.,.,[4,23].Ou[24]PE、PTFE、(PET),((NH4)2TiF6)(H3BO3),(NH4)2TiF6H3BO3(TiO2),TiO2(7),MC-3T3.7　TiO2[24]Fig.7　AschematicviewoftheTiO2depositiononthepolymersubstratesmediatedbypolydopamine2.3　,.-(、、π-π、),[1,2].,,..Fan[25],ATRP,316L(8),3T3,.,(、).,,　·36　　　·《》3031　.Lee[26]PDMS,,/.Lee[27](PEI)(HA),(Layer-by-Layeras-sembly,LbL)、、PEIHA,.Lee[28]PEG(9),PEG,.2.4　,.,,,,LbL.Bernsmann[29]　3:-·37　　　·　,,.,,.Chen[30](PES),(CS),CS/PES,,.3　结论与展望,、、.-.:1)、、,(PTFE),.2),,.3),,.,-、、、,.[1]LeeH,SchererNF,MessersmithPB.Single-moleculemechanicsofmusseladhesion[J].PNatlAcadSciUSA,2006,103:12999-13003.[2]LeeH,DellatoreSM,MillerWM,etal.Mussel-in-spiredsurfacechemistryformultifunctionalcoatings[J].Science,2007,318:426-430.[3]WaiteJH.Surfacechemistry-musselpower[J].NatMater,2008,7:8-9.[4]SeverMJ,WeisserJT,MonahanJ,etal.Metal-medi-atedcross-linkinginthegenerationofamarine-musseladhesive[J].AngewChemIntEdit,2004,43:448-450.[5]YuME,HwangJY,DemingTJ.RoleofL-3,4-di-hydroxyphenylalanineinmusseladhesiveproteins[J].JAmChemSoc,1999,121:5825-5826.[6]ZhaoH,WaiteJH.Linkingadhesiveandstructuralproteinsintheattachmentplaqueofmytiluscalifornia-nus[J].JBiolChem,2006,281:26150-26158.[7]BurzioLA,WaiteJH.Cross-linkinginadhesivequinoproteins:studieswithmodeldecapeptides[J].Bio-chemistry-US,2000,39:11147-11153.[8]vanderLeedenMC.Areconformationalchanges,in-ducedbyosmoticpressurevariations,theunderlyingmechanismofcontrollingtheadhesiveactivityofmusseladhesiveproteins[J].Langmuir,2005,21:11373-11379.[9]XiZY,XuYY,ZhuLP,etal.Afacilemethodofsurfacemodificationforhydrophobicpolymermem-branesbasedontheadhesivebehaviorofpolyDOPAandpolydopamine[J].JMembrSci,2009,327:244-253.[10]KuSH,RyuJ,HongSK,etal.Generalfunctional-izationrouteforcelladhesiononnon-wettingsurfaces[J].Biomaterials,2010,31:2535-2541.[11]YuF,ChenSG,ChenY,etal.Experimentalandtheoreticalanalysisofpolymerizationreactionprocessonthepolydopaminemembranesanditscorrosionpro-tectionpropertiesfor304StainlessSteel[J].JMolStruct,2010,982:152-161.[12]LiB,LiuWP,JiangZY,etal.Ultrathinandstableactivelayerofdensecompositemembraneenabledbypolydopamine[J].Langmuir,2009,25:7368-7374.[13]PanFS,JiaHP,QiaoSZ,etal.Bioinspiredfabrica-tionofhighperformancecompositemembraneswithultrathindefect-freeskinlayer[J].JMembrSci,2009,341:279-285.[14]KangSM,YouI,ChoWK,etal.One-stepmodifi-cationofsuperhydrophobicsurfacesbyamussel-in-spiredpolymercoating[J].AngewChemIntEd,2010,49:9401-9404.[15]YuB,LiuJX,LiuSJ,etal.Pdoplayerexhibitingzwitterionicity:asimpleelectrochemicalinterfaceforgoverningionpermeability[J].ChemCommun,2010,46:5900-5902.[16],　,　.PTFE[J].,2010,4:479-483.[17]LeeH,RhoJ,MessersmithPB.Facileconjugationofbi-omoleculesontosurfacesviamusseladhesiveproteinin-spiredcoatings[J].AdvMater,2009,21:431-434.　·38　　　·《》3031　[18]McCloskeyBD,ParkHB,JuH,etal.Influenceofpolydopaminedepositionconditionsonpurewaterfluxandfoulantadhesionresistanceofreverseosmosis,ul-trafiltrationandmicrofiltrationmembranes[J].Poly-mer,2010,51:3472-3485.[19]JiangJH,ZhuLP,LiXL,etal.Surfacemodifica-tionofPEporousmembranesbasedonthestrongad-hesionofpolydopamineandcovalentimmobilizationofheparin[J].JMembrSci,2010,364:194-202.[20]LiCY,WangWC,XuFJ,etal.Preparation