白术化学成分和药理作用的研究进展-杨娥

510006、、、、、、。30。R962Adoi10．3969/j．issn．1006-8783．2012．02．0291006-8783201202-0218-04AdvanceonthechemicalconstituentsandpharmacologicaleffectsofAtractylodesmacrocephalaKoidz．YANGEZHONGYan-meiFENGYi-fanGuangdongPharmaceuticalUniversityGuangzhou510006ChinaAbstractRhizomeatractylodesmacrocephalaeisthedryrootsofAtractylodesmacrocephalaKoidz．Itmainlycontainsvolatileoilatractylenolidesatractylodespolysaccharidesglycosidesandaminoacids．Andithasthemedicalfunctionsofgoodforspleenandintestinediureticanddehumidificationanti-inflammatoryantitumorandsoon．InordertoprovidereferencesforfurtherdevelopmentandutilizationthispaperreviewedthesestudiesaboutthechemicalconstituentsandpharmacologicaleffectsofAtractylodesmacrocephalaKoidz．inrecent30years．KeywordsAtractylodesmacrocephalaKoidz．chemi[e-mail][e-mail]。2012-03-261149http//．cnki．net/kcms/detail/44．1413．R．20120326．1149．002．htmlCompositaeAtractylodesmacrocephalaKoidz．1。、2、、、、、、、、。、、、“”。、、、。、、、、、3。。11．1100、、、4－6。4－547。ⅠatractylenolideⅠ8－9、ⅡatractylenolideⅡ8、ⅢatractylenolideⅢ8－9、ⅣatractylenolideⅣ10、biatractylenolide11、AtractylenolideV12、AtractylenolideⅥ12、AtractylenolideⅦ12、atractylone8、3β-3β-acetoxyatractylon13、13、AIsoasterolideA13、atractylenolactam14、8β-methoxyasterolid14、8β-ethoxyasterolid141。1．2JournalofGuangdongPharmaceuticalUniversityApr．2012282915A1、10-A2、B3、F24、D15、6、7、2E--46--18--8-O-β-D--1→6-β-D-8-β-D--1→6-β-D-9Han1630%60%5Scutellarein6-O-glucoside10、4H-1-Benzopyran-4-one6-β-D-glucopyranosyloxy-5-hydroxy-7-methoxy-2-phenyl-11、4H-1-Benzopyran-4-one8-β-D-glucopy-ranosyloxy-57-dihydroxy-2-4-hydroxyphenyl-12、Stereolensin13、2-Propenoicacid3-34-dihydroxy-phenyl-4-6-β-D-glucopyranosyl-57-dihydroxy-4-oxo-4H-1-benzopyran-2-yl-2-hydroxyphenylester2E-14uridine1715。2。1．3Gal、Rha、Ara、ManPSAM-1xyl、Ara、GalPSAM-218。19Glc、Gal、Rha、ManAMP。1．4、β-、3、、、4β-71520。Asp17721。21、22Ca、Mg、Mn、Fe。22．1、。23Ach、His。AchE、SP24－25。26。、27。2．2、、。、Ⅰ、Ⅱ、Ⅲ28－29。9Ⅰ。。、ⅠⅢHL-60P-38830。Huang31TJurkat、U937HL-60。32ⅠⅢα-TNFNO1Figure1AtractylenolidesinRhizomeatractylodesmacrocephalae9122．2Figure2GlycosidesinRhizomeatractylodesmacrocephalae。33－34。34SOD、GSH-PxDNA。FMDVFMDVIgGIgGFMDV35。Lee36Th1。2．3Na+K+-ATPNa+、K+37－38。、39。2．4。AMP-B40。α-41。β-42。43。、。3。、。1．M．2006193．2．M．1998201．3．10J．022282007182338－340．4．GC/MSJ．2006261124－126．5．--J．200725143－47．6．GC-MSJ．20102710928－931．7．J．2011365578－581．8．J．2009326413－415．9LICui-qinHELang-chongDONGHai-yanetal．Screeningfortheanti-inflammatoryactivityoffractionsandcompoundsfromAtractylodesmacrocephalaKoidzJ．JEthnopharmacol20071142212－217．10．ⅣJ．1992348614．11．J．19953527．12DINGHsiou-yuLIUMei-yingCHANGWen-liangetal．NewsesquiterpenoidsfromtherhizomesofAtractylodesmacrocephalaJ．ChnPharmJ200557137－42．13．J．1991332164－167．14CHENZhong-liangCAOWen-yiZhouGuo-xinetal．AsesquiterpenelactamfromArtractylodesmacrocephalaJ．Phytochemistry1997454765－767．15KITAJIMAJKAMOSHITAAISHIKAWATetal．GlycosidesofAtractylodesovataJ．ChemPharmBull20035191106－1108．16HANJHKIMJKIMSetal．Anti-oxidativecompoundsfromtheaerialpartsofAtractylodesmacrocephalaKoidzumiJ．YakhakHoeji200751288－95．17．J．200738101460－1462．18．J．2001249647－648．19．J．2007233185－188．20JIANGHaiSHIJingLIYuan-yuan．ScreeningforcompoundswitharomataseinhibitingactivitiesfromAtractylodesmacrocephalaKoidzJ．Molecules20111643146－3151．21．J．2006297679－680．22．J．200825655－56．23．J．19992212636－640．24．J．2001106365－68．25．PJ．200320114－16．26．J．20082491－3．27．J．2011306417－419．28SINKSKIMHPLEEWCetal．PharmacologicalactivitiesoftheconstituentsofAtractylodesRhizomesJ．ArchPharmRes1989124236－238．29WANGChang-heDUANHai-jieHELang-chong．InhibitoryeffeteofatractylenolideⅠonangiogenesisinchronicinflammationinvivoandinvitroJ．EurJPharmacol20096121/3143－152．30WANGChing-chiungCHENLih-geengYANGLing-ling．CytotoxicactivityofsesquiterpenoidsfromAtractylodesovateonleukemiacelllinesJ．PlantaMed2002683204．31HUANGHuey-lanCHENChien-chihYEHChin-yietal．ReactiveoxygenspeciesmediationofBaizhu-inducedapoptosisinhumanleukemiacellsJ．JEthnopharmacol200597121－29．32LICui-qinHELang-chongJINJu-qing．AtractylenolideⅠandatractylenolideⅢinhibitLipopolysaccharide-inducedTNF-alphaandNOproductioninmacrophagesJ．PhytotherRes2007214347－353．33．J．19961919－10．34．D-J．200626121658－1660．35LIRui-liSAKWIWATKULKLIYutaoetal．Enhancementoftheimmuneresponsestovaccinationagainstfoot-and-mouthdiseaseinmicebyoraladministrationofanextractmadefromRhizomaAtractylodismacrocephalaeRAMJ．Vaccine200927152094－2098．36LEEJCLEEKYSONYOetal．StimulatingeffectsonmousesplenocytesofglycoproteinsfromtheherbalmedicineAtractylodesmacrocephalaKoidzJ．Phytomedicine2007146390－395．37．J．1961243/4227－237．38SATOHKNAGAIFUSHIYAMAKetal．SpecificinhibitionofNa+K+-ATPaseactivitybyattractylonamajorcomponentofByaku-jutsubyinteractionwithEnzymeintheE2stateJ．BiochemPharmacol1996513339－343．39．J．200717329－31．40．AMP-BJ．2003386438－441．41GAOHongHUANGYi-naGAOBoetal．Inhibitoryeffectonα-glucosidasebyAdhatodavasicaNeesJ．FoodChem20081083965－972．42NOJIMAHKIMURAIKIMURAM．Blockingactionofsuccinylcholinewithbeta-eud