高纯乙腈的应用及其提纯与精制工艺

:2009-11-20:(1983),,,,;:(1973),,,,Emai:[e-mail]白聪丽,张奔,罗艳(,201620):;,;,:;;:TQ226.61:A:1008-021X(2010)03-0022-06ApplicationofHigh-purityAcetonitrileandItsPurificationandRefiningProcessesBAICong-li,ZHANGBen,LUOYan(AppliedChemistryDepartmen,tCollegeofChemistry,ChemicalEngineeringandBiotechnology,DonghuaUniversity,Shanghai201620,China)Abstract:Introducedthecurrentapplicationofhigh-purityacetonitrile.Anddiscussedtheremovalmethodsaswellastherelatedprinciplesofthemainimpuritiesincrudeacetonitrile,suchashydrocyanicacid,acrylonitrile,aldehydesandketones,oxazole,allylalcoholandwater.Thegeneraloverviewoftheadvancedhigh-purityrefinedacetonitrileprocessesandtheircontrastwiththetraditionalrefiningprocessweresummarized.Furthermore,thedevelopmenttrendofrefinedacetonitrileprocesswasprospected.Keywords:high-purityacetonitrile;purification;refined(CH3CN),,,(HPLC),DNA/EL,[1-4],2%~3%l8t,5400,t5t,1000t~1200t[4],,,,,,[5],,20904000t[6]18000,t907000/,t14800/t,,,,,11.1[7-8]200nm~400nm,,HPLC,10-9,1.2[9-10],,C422SHANDONGCHEMICALINDUSTRY2010393,,,,,1.3[11-12],B1;,1.4[13],,,,,1.5[14-15],,,,2(Oxazole)()-[16]52%43.6%2.5%0.5%0.5%0.3%,0.6%[17]99%,99.9%,2.12%~3%1%[18]95%()(),[19-20],NaOH,:CH2=CHCN+HCNCNCH2CH2CNCH2O+HCNCNCH2OHCNCH2OH+NaOH+H2OHOCH2COONa+NH3CNCH2OH+H2ONH2CH2COOHHCN+NaOHNaCN+H2O2.20.1%~0.2%200nm~260nm,190nmHPLC,,,,:CH2=CHCH2CHO+KMnO4+NaOHCH2=CHCH2COONaCH2=CHCH2CHO+KMnO4+NaOHCH2=CHCOONa2.30.01%,,0.5%,,,1%,,,,[21],,,:CH2=CHCH2OH+H2SO4CH2=CHCH2OHSO3CH2=CHCH2OH+CH2=CHCH2OHCH2=CHCH2H2CH=CH2Ota,Hitoshi[22],,-,,23,:Himes,BarryW[23],,,,,DNA,,2,[24],[25],,,,,,2.4(16%,84%,76!),,-2.4.1,,,,10%,,20%,5∀10-4,[18],2.4.2-,,,,[26]-,-,,99%,85%,,,2.4.3[26]-,,,-,,33.12070,[1],:#,∃,,%,65%~70%&,99%80,Standardoil,,[1],,65%80%1991,BP,90%,99.8%[12]90,1kt,85%,99.5%[5][27-28]1,,,,,,-,,,,24SHANDONGCHEMICALINDUSTRY2010393图1乙腈精制工艺流程图Fig.1Theprocessflowchartofacetonitrilepurification,,,(),,,,,,,,99.9%,85%,HPLC3.2[29]-,2V1.;V2.-;V3.;V4.;V5.;V6.;R1;R2;T1.;T2.;P1.图2利用超重力旋转床回收乙腈的工艺流程图Fig.2FlowsheetofacetonitrilerecoveryusingRZB:R1,P1R2,R2,R2,P1R1,,,R1R2R125,:T1,,-V2,R2,T2,V5,,V3,,,V4,V6,,,99.5%,,,1992KennyGerard[30],3342,,16,726,89,101.;2.;3.;4.;5.;6.7.;8.;9.;10.图3高纯乙腈精制装置图Fig.3Installationofhigh-purityrefinedacetonitrile99.8%,2007KennyGerry,4[31]1.;2.;3.;4.;5.;6.;7.;8.;9.;10.;11.;12.;13.;14图4改进后高纯乙腈精制装置图Fig.4Installationofhigh-purityrefinedacetonitrileafterimproving2,67,814,10119,1213[4],,,,HPLC,,4,,,,,,,26SHANDONGCHEMICALINDUSTRY2010393,:,,;/DNA/;HPLC,,,参考文献[1].[J].,1992(5):24-27.[2],.[J].,2004,33(6):26-27.[3]Seeboth,Helmuth,Mitschke,eta.lUtilizationofacetonitrile[J].ChemischeTechnik,1971,23(12):746-748.[4],,.:JP,200680015870[P].2006-05-10.[5]ReadCS.[J]..,1994(2):35-39.[6].[J].,1998,27(5):367-373.[7].[D].:,2002.[8],,,.[J].,2003,21(3):266-269.[9].[J].,1993,21(4):1-4.[10]ParkerAJ,MuirPM,SmartYC.Applicationofacetonitrileleachinganddisproportionation.Refiningsegregatedcopperfromroastedconcentratesandores[J].Hydrometallurgy,1981,7(3):213-233.[11].[M].:,1990:754-759.[12],.[J].,1996(4):47-49.[13]PressonRD,Bedford,WuHsin-Chih,eta.lContinuousacetonitrilerecoveryprocess:US,4362603[P].1982-07.[14].[J].,1997(2):37-49.[15]MatsuokaYuj,iKajiHajime.Preparationofhigh-purityacetamidefromacetonitrile:JP,2000095742(A)[P].2000-04-04.[16].[J].,2003(3):11.[17]SanjayPurushottamGodbole,RichardLeeWappelhorst,PaulAlanJacobson.Purificationandrecoveryofacetonitrile:US,6326508B1[P].2001-12-04.[18].[J].,2001,30(10):785-788.[19],,.[J].,1999,28(8):555-558.[20],,.[J].,1996,25(3):122-127.[21].:JP,200410038023.8[P].2004-05-12.[22]Ota,Hitosh,iKurihara,eta.lPurificationofacetonitrile:JP,10025272[P].1998-01-27.[23]Himes,BarryW,Greenough,RClive.Purificationofacetonitrilebytreatmentwithozone:US,5426208[P].1995-06-20.[24].[J].,2005,25(4):46-48.[25],,.:,CN200710191598.7[P].2007-12-13.[26],,,.-[J].,2007,36(12):1229-1233.[27].[J].,2001(4):44.[28],.[J].,2002,12(5):14-16.[29],,,.[J].,2008,39(1):4-6.[30]KennyGerard,MilesHarcourt.Purificationofacetonitrile:UK,GB2249308A[P].1992-05-06.[31]KennyGerry.Acetonitrilepurificationbytheadditionofphosphoruspentoxide,thenwaterandsubsequentdistillation:UK,GB2435040[P].2007-08-15.(:,,.[J].,2010,39(3):22-27.)27,: