©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(3):327233128KrajewskaM,TurnerBC,ShabaikA,etal1ExpressionofBAG21proteincorrelateswithaggressivebehaviorofprostatecancersJ1Prostate,2006;66(8)801210129VoraHH,MehtaSV,ShahKN,etal1CytoplasmiclocalizationofBAG21inleukoplakiaandcarcinomaofthetongue:correlationwithp53andc2erbB2incarcinomaJ1IntJBiolMarkers,2007;22(2):10027130DobbynHC,HillK,HamiltonTL,etal1RegulationofBAG21IRES2me2diatedtranslationfollowingchemotoxicstressJ1Oncogene,2008;27(8):1167274120092062252009211216(/)(,252059);;;Q255A100529202(2010)0921311203:(19692),,,,,,,,,,15,1,,(CMA)6,7,CMA,CMA70(HSP70),,LAMP22A(Lamp22A),CMALAMP22A7,LAMP22A,,CMA,,CMACMA,,,,3,8DAF229,,10,(Atg)Atg7Atg4Atg9,,,11212,13,p62,p62,LC3(LC3),p62145,DAF22,Beclin1bec21DAF22,15,,,,,,DAF216/FoxO,,DAF216/FoxO16,,,17,DAF22,183,,11319©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:66427312KirkwoodTBL1AsystematiclookatanoldproblemJ1Nature,2008;451:6442713VellaiT1AutophagygenesandagingJ1CellDeathDiffer,2009;16:94210214VijgJ1TheroleofDNAdamageandrepairinaging:newapproachestoanoldproblemJ1MechAgingDev,2008;129:498250215ThomasE1JohnsonCaenorhabditiselegans2007:thepremiermodelforthestudyofagingJ1ExpGerontol,2008;43:12416CuervoAM1Autophagyandaging:keepingthatoldbroomworkingJ1TrendsGenet,2008;24:60421217ZhangC,CuervoAM1Restorationofchaperone2mediatedautophagyinag2ingliverimprovescellularmaintenanceandhepaticfunctionJ1NatMed,2008;14:95926518YenWL,KlionskyDJ1Howtolivelongandprosper:autophagy,mito2chondria,andagingJ1Physiology(Bethesda),2008;23:24826219HarsES,QiH,RyazanovAG,etal1AutophagyregulatesageinginC1elegansJ1Autophagy,2007;3:9325110SimonsenA,CummingRC,BrechA,etal1Finley,promotingbasallevelsofautophagyinthenervoussystemenhanceslongevityandoxidantre2sistanceinadultDrosophilaJ1Autophagy,2008;4(2):176284111YoshimotoK,HanaokaH,SatoS,etal1ProcessingofATG8s,ubiquitin2likeproteins,andtheirdeconjugationbyATG4sareessentialforplantautophagyJ1PlantCell,2004;16(11):2967283112DonatiA,AnnamariaV,GabriellaC,etal1Invivoeffectofanantilipo2lyticdrug(3,502dimethylpyrazole)onautophagicproteolysisandauto2phagy2relatedgeneexpressioninratliverJ1BiochemBiophysResCommun,2008;366:786292113RavikumarB,VacherC,BergerZ,etal1InhibitionofmTORinducesau2tophagyandreducestoxicityofpolyglutamineexpansionsinflyandmousemodelsofHuntingtondiseaseJ1NatGenet,2004;36:585295114PankivS,ClausenTH,LamarkT,etal1p62/SQSTM1bindsdirectlytoAtg8/LC3tofacilitatedegradationofubiquitinatedproteinaggregatesbyautophagyJ1JBiolChem,2007;282:24131245115BraeckmanBP,VanfleterenJR1GeneticcontroloflongevityinC1ele2gansJ1ExpGerontol,2007;42:9028116HansenM,TaubertS,CrawfordD,etal1Aroleforautophagyintheex2tensionoflifespanbydietaryrestrictioninC1elegansJ1PLoSGenet,2008;4:e24117KangC,Young2jaiY,AveryL,etal1Dualrolesofautophagyinthesur2vivalofCaenorhabditiselegansduringstarvationJ1GenesDev,2007;21:2161271118CohenE,BieschkeJ,PerciavalleRM,etal1Opposingactivitiesprotectagainstage2onsetproteotoxicityJ1Science,2006;313:1604210119PattingreS,EspertL,Biard2PiechaczykM,etal1Regulationofmacroau2tophagybymTORandBeclin1complexesJ1Biochimie,2008;90:313223120Djavaheri2MergnyM,JavelaudD,WietzerbinJ,etal1NF2Bactivationrepressestumornecrosisfactor22inducedautophagyJ1JBiolChem,2006;281:30373282121SchlottmannS,BubackF,StahlB,etal1ProlongedclassicalNF2Bacti2vationpreventsautophagyuponE1colistimulationinvitro:apotentialresolvingmechanismofinflammationJ1MediatorsInflamm,2008;21312010530©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:337429123FengZ,ZhangH,ArnoldJ,etal1Thecoordinateregulationofthep53andmTORpathwaysincellsJ1ProcNatlAcadSciUSA,2005;102:820429124TasdemirE,MaiuriMC,OrhonI,etal1Regulationofautophagybycyto2plasmicp53J1NatCellBiol,2008;10:676287125MatheuA,MaraverA,SerranoM1TheArf/p53pathwayincancerandagingJ1CancerRes,2008;68:603124120092072292009212223(/)(,410004);;R33913+6A100529202(2010)0921313202:(19542),,,21,1,,1,23031613163,,3:19581959,9050;;;441980198110090,,,,,,,22519911993;344,,73,,36,3,3;3,,;3,,63,,,:,,,,,,,24232100,16,1,,,;,,,,,,722111000,,,8:21111,,,,,,,,,21112,,:,,,,(),:,,,:,,21113:,,,,,21114,,,,,,,31319