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(361000):A(HbA),F(HbF),A2(HbA2),HbA,3:HbA1a,HbA1bHbA1c,[1](HbA1c),,,1.5,120d,60d,12[2],,,2HbA1c2070,,[3]:,;,(HPLC)[4]11.1[4-7],N,(GHb)HbA,,,GHb,HbApHGHbHbA,KCNHb,Hb,,HbA1c,TOSOH(DCCT),HPLCHbA1cHLC-723G73.6min,,,GHbBio-Rex70,,SCIENTIFICHb-Gold,,600,,,:(HB-F)HbA1c,HPLCHb-F,HbA1c()1.2[8],,HbF,,Bio-RadBIOSYSTEMS,DREWSCIENTIFICDS5(Bio-RadIASTA),,,S(HbS)C(HbC),,,,(CV)2%,,5min,,,,,,1.3[9]HbHbA1,HbAN-,HbA,,,HbA1GHb,HbA1HbHbAHbA1,,1.4GHb,(ampholin)pH,pH,,,HbAHbAcHbFHbSHbC,,,,1.5[10],,,,,,,GHb,GHb,GHb,HbGHb,HbF,(),()621JournalofClinicalandExperimentalMedicineVol.8,No.2Feb.2009GHb,Hb,415nmGHbDREWSCIENTIFICDST,10l4min,,,,,CV5%:,,,,:,GHb,HbA1,GHbGHb,GHb,,GHb,HbA,HbAc,GHbHPLCHbA,HbAc2h,[11]1.6,AbbottIMX,,,,,IMX,,,,,1.7[12],,(DCA2000),7min,,,,,,1.8(),,NycoCardReaderII[13]1.9,,,,,,,,,,,,,,,[14]1.10:,,:,,1.11Hb,35minHb,(FAOD)H2O2,H2O2PODDA-64,751nmGHb[15]2,,HPLC,,,,,,,,,,GHb,[16]GHbHbA1,HPLC,,,,[1].[J].,1995,3(3):169-172.[2].[J].,2007,16(7):959-960.[3]KennedyL,etal.Glycationofhemoglobinandserumproteins[M].In2terna-tionalTextbookofDiabetesMellitus.Chichester;JohnWil2leyandSon.1992:985-1007.[4].[J].,2007,14(21):2937-2939.[5],,,.[J].,2003,18(2):119-121.[6],,.[J].,2001,23(9):1124-1125.[7],.[J].,2008,24(2):84-87.[8],,,.[J].,2007,22(4):185-186.[9],.[J].,2003,1(2):101-102.[10],,,.[J].,1994,16(5):39-41.[11],,,.[J].,2007,4(5):381,383.[12],,.[J].,2005,(5):213-214.[13],.[J].,2007,2(13):101-102.[14],.[J].,2003,21(6):503.[15].[J]..,2003,24(6):387.[16].[J].(),1994,37:855-864.(:2008-12-09)7212009282