有毒生物碱性质与分析-孟品佳

檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾殧殧殧殧[e-mail]10041003462010-01-132010-03-12、、、、、、、、、、。PropertiesandAnalysisofToxicAlkaloidsMengPinjiaForensicScienceDepartmentChinesePeople'sPublicSecurityUniversityBeijing100038AbstractThepaperswhichpublishedinEnglishrecentlyconcerningtheanalysisoftoxicalkaloidsinbodyfluidaresummarized.Thepropertiessymptomsoftheintoxicationsandthemethodsofdetectionoftheirtoxicconstituentsinbiologicalfluidsofsometoxicalkaloidssuchasaconitineatropineconiinecolchicinecytisinedimethyltryptamineharmineharmalineibogainekawainmescalinescopolamineandtaxinewhichareofteninvolvedinfatalandnon-fatalpoisoningsareintroduced.Itmaybehelpfultounderstandthestatusofthepoisoningandtheanalysisofthetoxicalkaloidscomprehensively.KeywordsAlkaloidToxicplantToxicology、。3、。。。1。。。。。。2。、。。、。。·484·20106http//。。1、。、、。。。。、3。1、Tab.1ListofcommonnamesofplantscontainingtoxicalkaloidsrelevantinforensictoxicologytheirassociatedbotanicalnamesandtheirmajoractivealkaloidsAconitineMonkshoodWolf’sBaneBelladonnaDeadlyNightshadeDwaleAutumnCrocusMeadowSaffronNakedLadyHemlockPoisonHemlockAngel’sTrumpetJimsonWeedThornAppleLaburnumGoldenChainTreePeyoteDevineCactusMescalButtonBlackHenbaneStinkingNightshadeBanisteriopsisspec.AyahuascaPsychotriaviridisAyahuascaNN-KavaYaqonaYewEuropeanYew1。。。26。。5。。。。。、。SPE46LLE7。1997Ito8GC/MSTMS。-LC/MS67。1。2、“”、“”、“”。Atropa·584·http//。belladoanna。A.belladoanna。。Atropa。Angel’sTrumpets。A.belladoannaS---S---。S---50%L-D-S---。。。。、、、。、。GC/MS9。9。LC/MS1011。3maculatum。。、。。2。C.maculatum、。。γ-。。。、、、12。Drummer121-GC/MS3γ-。1995Holstege13。LLEC18SPEGC/MS。114SPELC/MS。4autumnale。、、。。“”。。14。、。。。2000。。。。BeyerSPEC8。。14。HPLC-UV。Chen15C18UV350nm。Clevenger16GC/MS·684·20106http//。LC/MS14。17。5。“goldregen”。。。。。。。。。。114。。。6、、NN-DMT、、NN-。。“”。BanisteriopsiscaapiNN-。PsychotriaviridisDMT。DMT1000mg25mg。MAO18。β-、19。β-MAO。DMT18。DMTβ-。DMT1-GC/NPD20。β-HPLC20。Sklerov21GC/MS25。5--DMT5-MeO-DMT。5-MeO-DMT22。DMTβ-。7Tabernantheiboga。6wt%tabernanthineibogalineibogamine。12-。5HT2Aκ-μ-。。μ-。23。、24。5～8h·784·http//。TMDMS2526GC/MS。5～10ng/mL。LC/MSESIC1822C8。1--V/V=4/125-V/V=95/523。WaterSPE。8。1977JohannGregorForster、。methysticum。。。、、、、、27。。28。。29。。。KoeppedTenczer30GC/MS10。Duffield31GC/MS7。MS/MS3233。。32。Villian33GC/MS/MS。Optima-5MSMRM。9。。30。、。。。3780～3660。。。。LSD-4-5-HT。。34。1135。LLE1-34SPEC8GC/MS35。GC/MS35。LC/MS。·884·20106http//。10Taxusbaccata。。。。T.baccataB。、、、。。Beike36C18LC/MS/MSMRM、、BB。Frommherz36SPEC18LC/MS/MSMRM422BB105～212ng/g。11。。。。1FSchneiderPLutunPKintzetal.J.Toxicol.Clin.Toxicol.199634113～117.2CGDaughertyJ.Med.Bioorg.19953178～182.3JBeyerOHDrummerHHMaurer.ForensicSci.Int.20091851～9.4NYoshiokaKGonmoriATagashiraetal.ForensicSci.Int.199681117～123.5HTFengLLYuanSFLi.J.Chromatogr.A2003101483～91.6HOhtaYSetoNTsunodaetal.Sci.Appl.1997691351～356.7YFujitaKTeruiMFujitaetal.J.Anal.Toxicol.200731132～137.8KItoSTanakaSKonnoetal.J.Chromatogr.BBiomed.Sci.Appl.1998714197～203.9ANameraMYashikiYHiroseetal.ForensicSci.Int.200213034～43.10AXuJHavelKLinderholmetal.J.Pharm.Biomed.Anal.19951433～42.11JBeyerFTPetersTKraemeretal.J.MassSpectrom.200742150～160.12OHDrummerANRobertsPJBedfordetal.Med.J.Aust.1995162592～593.13DMHolstegeJMSeiberFDGaley.J.Agric.FoodChem.199543691～699.14JBeyerFTPetersTKraemeretal.J.MassSpectrom.200742621～633.15QHChenSHouLCGanetal.YakugakuZasshi20071271485～1490.16CVClevengerTFAugustLMShaw.J.Anal.Toxicol.199115151～154.17PKintzCJameyATracquietal.J.Anal.Toxicol.19972170～72.18JRibaMValleGUrbanoetal.J.Pharmacol.Exp.Theor.200330673～83.19JCCallawayGSBritoESNeves.J.PsychoactiveDrugs200537145～150.20JCCallawayLPRaymonWLHearnetal.J.Anal.Toxicol.199620492～497.21JSklerovBLevineKAMooreetal.J.Anal.Toxicol.200529838～841.22JCCallawayCSGrobDJMcKennaetal.J.Anal.Toxicol.200630406～407.23MChezeALenoanMDeveauxetal.ForensicSci.Int.200817658～66.24KRAlperHSLotsofGMFrenkenetal.Am.J.Addict.19998234～242.25MEAlburgesRLFoltzDEMoody.J.Anal.Toxicol.199519381～386.26WLHearnJPabloGWHimeetal.J.Anal.Toxicol.199519427～434.27DDJamiesonPHDuffieldDChengetal.Arch.Int.Pharmacodyn.Theor.198930166～80.28HPVolzMKieser.Pharmacopsychiatry1997301～5.·984·http//～1300.30CKoppelJTenczer.J.Chromatogr.1991562207～211.31AMDuffieldDDJamiesonROLidgardetal.J.Chromatogr.1989475273～281.32FTarbahHMahlerBKardeletal.J.Chromatogr.BAnalyt.Technol.Biomed.LifeSci.2003789115～130.33MVillainVCirimeleATracquietal.J.Chromatogr.BAnalyt.Technol.Biomed.LifeSci.2003798351～354.34JLHenryJEpleyTPRohrig.J.Anal.Toxicol.200327381～382.35VHabrdovaFTPetersDSTheobaldetal.J.MassSpectrom.200540785～795.36JBeikeBKargerTMeinersetal.Int.J.LegalMed.2003117檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴殜殜殜殜335～339.………………………………………………－…………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………－……………………………………H6P2W18O62/TiO2P123…………………………………