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:100021336(2000)0420156203DNA,,(,100005):SV40;DNA;:Q591.3:A:2000204219:(1977),,;(1945),,,;(1938),,DNA,DNA,90SV40DNADNASV40DNAT,SV40DNA,DNA1.DNADNA/5DNA()DNA,,DNA[1],(PCNA)DNA,DNARFCPCNA,DNADNA[2]90,,DNADNA,:DNARNA5DNA(initiatorDNAiDNA,DNA),DNA,DNA[34],90,,,DNADNA,DNA/,:(1)1991Bullock,SV40DNAPCNA,((200nt),iDNAPCNADNA()[5](2)19881991,RobertsSV40DNA,,DNA,DNA35,,30[67](3)1994,WagaStillmanSV40DNADNA,DNADNA(PCNA,RFC),,DNA.DNA,WagaStillman6512000204,,RFCPCNADNA(RPA)DNA,RFCPC2NA,DNA,DNA,,DNA/[89],,DNARNAiDNA,RNA2DNA,DNADNA,DNADNA,DNA,RNASV40DNA:T,DNA,RPA1,DNARPADNARNA2DNA,RNA2DNA,RFCDNAiDNA3RFCDNAATP,ATPPCNA,DNA,RFC2DNARFCPCNA2DNADNAPCNADNA,RFCATPDNA,DNA2,DNADNA[1011]PCNADNA,PCNA,E.coliDNA,DNA,DNA,DNA1DNA[8]2.SV40510kb,,RNA,DNAIWagaStillman,,RNA(2),RNaseH/FEN1,Dna2/FEN1[11]2RNA[11](1)RNaseH/FEN1,RNaseH5RNA,FEN1537512000204RNaseH,,:DNA5RNA,DNA5FEN1(flapendonuclease)53DNA,5,(flap),FEN1,,;DNA52,,FEN153,FEN1,,5108bpDNA(312bp):DNA,,(2)Dna2/FEN1Dna2DNAATP35Dna235,DNADNA,,FEN1Dna2/FEN1,Dna2FEN1,WagaStillman,5RNA,DNAiDNADna2,FEN1,DNA(),35,;DNA,iDNA(),[11],DNA:(1)DNA;(2),,;(3)DNA,DNA,DNADNA,[1]FryLAetal.AnimalCellDNAPolymerase,1986,(CRC,Bocaraton,FL)[2]TsurimotoTetal.MolCellBiol,1989,9:609619[3]LodishHetal.MolecularCellBiology.3rded.NewYork,1995,378380[4]TsurimotoTetal.Nature,1990,346:534539[5]BullockPAetal.MolCellBiol,1991,11:2350[6]RobertsJDetal.ProcNatlAcadSciUSA,1991,88:34653469[7]RobertsJDetal.ProcNatlAcadSciUSA,1988,85:70647068[8]WagaSetal.Nature,1994,369:207212[9]HerendeenDetal.SV40DNAReplication.In:BlowJ(ed).EucaryoticDNAReplication,1996,pp2965[10]PeterMJBurgers.Chromosoma,1998,107:218227[11]WagaSetal.AnnuRevBiochem,1998,67:7217518512000204