121231*2311.3100522.3100523.310052、。。。S188A0517-6611201336-13917-031890Koch1。、72-4。、、、5。。1、、6-7。/、8。、。、、9-11。113-16/1MelacineCorixaGSK/1999ⅢFDAFDA2DCVax-Brain/2007II3OncophageAntigenicsgp96/2008FDAFDAEMEA、“”。4OncoVaxVicalIncorporat-edBCG、/20082011FDA5M-VaxAVAXDNP/2000、/20051999FDA“”6CIMACAXEGFR/20087ProvengeDendreon/2010FDA1986-。*。2013-12-0222.115JournalofAnhuiAgri.Sci.2013413613917-1391913939、、、、、、HIV、、3/412。71ProvengeFDAEMA2-4。2.230068%HBV、HIV、1217。120122Ⅱ、Ⅲ1Allovectin-7VicalⅢMHC-IDNA2Belagenpumatucel-LNovaRxⅢTGF-beta23BLP-25MerckSeronoⅢMuc14BiovaxIDBiovestⅢ5TG4010TransgeneⅢMUC-1-26TroVaxOxfordⅢ5T47LucanixNovaRxⅢTGF-beta28AGS-004ArgosTherapeuticsHIVⅡRNA9DermaVirGeneticImmunityHIVⅡDNA10DiamydDiamydmedicalⅠⅢGADⅠ11IC41IntercellⅡ512MVA-BBavarianNordicHIVⅡ413TovaxinOpexaⅡT14GI-5005GlobeImmuneⅡHCVNS3。。、18。。33.1HBV、900019。9300280020。3.1.1。HBsAgHBVFc2007Ⅲ2011E21-22。3.1.2。458819312013DNAPCRHBVpreS2.SIL-2/IFN-γHBV。Ⅰ23。3.2。Ⅱ24。———APDC。2012SFDAⅢ25。、2011ⅠHIV26。、。1/3。44。。4.1、、“”。。。Ⅲ。。4.227。。。、、。Ⅲ。。M-VaxMelacine28。5FDA44%、AIDS、、、。5、、、、。。。1KIRKWOODJMBUTTERFIELDLHTARHINIAAetal.Immunother-apyofCancerin2012J.CACancerJournalforClinicians2012625309-335.2KEIJZERCVANDERZEERVANEDENWetal.Treginducingadju-vantsfortherapeuticvaccinationagainstchronicinflammatorydiseasesJ.FrontImmunol2013204245.3MADANRASCHWAABTGULLEYJL.Strategiesforoptimizingtheclinicalimpactofimmunotherapeuticagentssuchassipuleucel-Tinpros-tatecancerJ.JNatlComprCancNetw201210121505-1512.4AKBARSMAL-MAHTABMUDDINMHetal.HBsAgHBcAgandcombinedHBsAg/HBcAg-basedtherapeuticvaccinesintreatingchronichepatitisBvirusinfectionJ.HepatobiliaryPancreatDisInt2013124363-369.5RethinkingtherapeuticcancervaccinesJ.NatRevDrugDiscov20098685-686.6GONZALEZGCROMBETTLAGEA.Chronicvaccinationwithathera-peuticEGF-basedcancervaccineareviewofpatientsreceivinglonglast-ingtreatmentJ.CurrCancerDrugTargets2011111103-110.7SCHLOMJGULLEYJLARLENPM.ParadigmshiftsincancervaccinetherapyJ.ExpBiolMedMaywood2008233522-534.139399193141361、∥kg186.72±18.06113.67±17.62∥cm128.70±10.5694.83±2.57∥cm133.00±7.32103.00±2.65∥cm139.89±5.23120.50±4.82∥cm14.01±1.1112.67±1.15∥kg186.72±18.06113.67±17.62∥kg12.03±2.016.57±0.12∥kg12.17±2.166.83±0.81∥kg2.58±0.261.48±0.08∥kg2.86±0.321.52±0.13∥kg0.67±0.460.28±0.09∥kg1.00±0.660.40±0.02∥kg80.30±15.7648.57±7.39∥kg60.12±10.1236.87±4.54∥kg20.18±7.1611.47±1.51∥%43.01±2.8642.47±0.92∥%32.20±3.0232.54±1.26∥%74.86±2.9776.12±2.11∥g/kg0.24±0.120.33±0.10∥g/kg2.79±1.122.06±1.12∥g/kg0.83±0.100.65±0.06∥g/100g11.22±0.829.68±0.171.M.2002.2.J.20095111-112.3.、J.20082637-10.4.M.2002.5.M.2010.6.J.20111013-14.7.J.201029667-68.8.F1J.2005253檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪57-58.139198VANDOORSLAERKREIMERSLLSTUDENTSORYYetal.Serologi-calresponsetoanHPV16E7basedtherapeuticvaccineinwomenwithhigh-gradecervicaldysplasiaJ.GynecolOncol20101162208-212.9PALUCKAKBANCHEREAUJ.Dendritic-cell-basedtherapeuticcancervaccinesJ.Immunity201339138-48.10TOPALIANSLWEINERGJPARDOLLDM.CancerimmunotherapycomesofageJ.ClinOncol201129364828-4836.11ROTHSCHILDSZIPPELIUSA.Cancerimmunotherapy-novelperspec-tivesJ.TherUmsch20126910559-563.12KIESSLINGAFUSSELSWEHNERRetal.Advancesinspecificim-munotherapyforprostatecancerJ.EurUrol2008534694-708.13HAMMERSTROMAECAULEYDHATKINSONBJetal.Cancerim-munotherapysipuleucel-TandbeyondJ.Pharmacotherapy2011318813-828.14SOSMANJASONDAKVK.MelacineanallogeneicmelanomatumorcelllysatevaccineJ.ExpertRevVaccines200323353-368.15DIPIETROATOSTIGFERRUCCIPFetal.OncophagesteptothefutureforvaccinetherapyinmelanomaJ.ExpertOpinBiolTher20088121973-1984.16RODRGUEZPCRODRGUEZGGONZLEZGetal.Clinicaldevel-opmentandperspectivesofCIMAvaxEGFCubanvaccinefornon-small-celllungcancertherapyJ.MEDICCRev201012117-23.17GUOCMANJILIMHSUBJECKJRetal.Therapeuticcancervac-cinespastpresentandfutureJ.AdvCancerRes2013119421-475.18WANGSCHENYW.Currentdevelopmentsituationofbiologicalmedi-cineindustrialparksandcountermeasuresinChinaJ.ChinesePharma-ceuticalAffairs201226101048-1051.19LIUSQGAOYQ.TheResearchdevelopmentofHBeAg-negativechron-ichepatitisBJ.ChineseHepatology2012176429-432.20FANGXLIANGZL.TheresearchdevelopmentofviralhepatitisvaccineinChinaJ.ChinPharmJ201247181425-1429.21WENYM.TheresearchdevelopmentofTherapeuticvaccinesJ.Chi-neseJournalofMicrobiologyandImmunology1996163155-158.22WENYMHELFQUT.Theresearchdevelopmentoftherapeuticre-combinanthepatitisBvaccineYICJ.EngineeringScience19991138-4257.23CHENGM.DevelopmentandapplicationoftherapeuticHBVDNAvac-cineJ.MedJChinPLA2003288489-492.24WANGYB.PreparationofMouse-anti-humanATPSynthaseF1DomainMonoclonalAntibodyandItsEffectsonProliferationandInvasionofCellsofPrimaryLiverCarcinomaD.ShanghaiTheSecondMilitaryMedicineUniversity2009.25CAOXT.DifferentiationantigenpresentationandfunctionalregulationofdendriticcellsJ.AeadJSecMilMedUni2004253547-549.26CAOZLZHUSL.TheepidemiologyandcurrentresearchofvaccineofHIV/AIDSinChinaJ.ActaAcademiaeMedicinaeCPAF20112010842-844.27GENGYHYANGLBIDZ.TheprogressofLiposomesasimmunologi-caladjuvantsJ.ChinPharmJ2007429649-651.28WUWTWANGYTWUWJ.Thesustainedandrapiddevelopmento