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2482005234R725A1000-3606(2005)04-248-03EB(610041)1EBVEBEREBNA-1EBNA-2EBNA-3A,3B,3CLMP-1LMP-2()-1)++----()-2)++--++()-3)++++++:1)Burkitt’s;2)T/NK/;3)(LCLs)2EBVVCAEAEBNAIgGIgM----IM()+++-IM()++/-+/--+-+/-+++/-+-EB(EBV)81958BurkittBurkitt1964EpsteinBarrBurkittEBV,EBV,EBV()EBV:EBVDNA,172Kb,100,(VCA)(EA)(EBVnuclearantigen,EBNA)[1]EBV,2:()()[2],DNA,VCAEA,,EBV(IM),VCAEA,EBNA-16LMP-1(latentmembraneprotein-1),,EBV()EBV:,B,EBNAsEBNA-2EBV,CD23LMP-1,B/EBVRNA(EBERs),EBER-1EBER-2RNA,EBV,EBNA,LMP1LMP2LMP2BLMP-1,,-B(NF-B),,EBV3EBV,1[3]EBV()EBV:EBVEBVEBV(2)()EBV:EBVLMPsWesternEBVDNASouthernEBERsNorthernPCREBVSlutherrEBV()EBV:EBVEBV,,EBVEBV()EBV1.(infectiousmononucleosis,IM):EBV,,50%IMIM,T,TEBVB(IM,)©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.24920052343CAEBVRickinson[8]:112EBV:(EA)(EBNA)3Kawa[9]:132EBV:EBV-VCAEA(EBV-VCAIgG11280),EBNA(EBV),34EBV(PCR)5,2./X-(fetalinfectiousmononucleosis/X-linkedlympho2proliferativesyndrome,FIM/XLP):Purtilo2070IM,X(XLP)XLP2.5,EBV,EBVIM,XLPTB,XLP(VAHS)CoffySayosXLP[4],T,XLP3.EBV(EBV-associatedhemophagocyticsyndrome,EBV-AHS):(VAHS),EBVEBV-AHS(DIC),,,,EBVCD8+T,(--IL-2IL-1IL-6M-CSFIL-10)EBV-AHS[5,6]4.Gianotti-Crosti:,,,EBV[7]()EBV:EBV:(chronicactiveEBVinfection,CAEBV),2080,TobiEBV,EBV(CAEBV)CAEBV:,,;,XLP;,1/3CAEBV;1/4EBV(NK);;EBV(VCAEA,EBNA)Ric-kinsonKawaCAEBV3[8,9]CAEBV,EBVCD4+T/NKCAEBV[6,10]CAEBV,1/235,EBV-AHSEBV()EBV1.Burkitt(BL):BL,,EBV(EBNA1),EBVEBER,,3:t(814)t(28)t(822),8c-myc21422Ig,c-myc,BLBL,BLEBVHIV3BL19881997291AIDS,115(40%)BLBLL(Burkittlikelymphoma,BLL)Davi[11]103AIDSBLL,B,68%c-myc,BL,,AIDSBLLBcl-2,AIDSBLLEBV79%,AIDSAIDS-BLBL,AIDS-BL2.B(posttransplantB-celllymphoproliferativedisorders,B-LPD):EBVB-LPD/,B,B-LPD,,EBV,EBV,EBV,;EBV,3.T:EBVT(©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.2502005234T)(PTCL)EBVPTCL,,,(),PTCL,,EBVT(NK)P-,4.NKNK/(NK-LPDandNKlymphoma/leukemia):NK,EBV,,,CD56+CD3-CD56+CD3+[13]NK,NKEBV,NKEBVEBVTEBVNK/,,T/NK:;,;;;;,5.(Hodgkindisease,HD):EBVHDWeissE2BVHDRSEBVHDEBV,30%90%RSEBVEBV,EBEREBNA-2LMP-1LMP-1NFKB,HDRS[14]()EBV1.(nasopharyngealcarcinoma,NPC):NPC,NPCEBV,EBV,NPC2.(gastricadenocarcinoma):EBV10%,EBVBurke(lymphoepithelioma,LE),EBV-DNAShibataBurke,LEEBEREBV,EBNA-13.(smoothmusclesarcoma,SMS):,EBV,:EBNA-123,EBER,LMP-1,AIDSAIDS,,,EBV1.GriffimBE.Epstein-Barrvirus(EBV)andhumandisease:facts,opinionsandproblems.MutatRes,2000,462(23):395-405.2.KawaK.DiagnosisandtreatmentofEpstein-Barrvirus-associ-atednaturalkillercelllymphoproliferativedisease.IntJHe-matol,2003,78(1):24-31.3.StraathofKC,BollardCM,RooneyCM,etal.ImmunotherapyforEpstein-Barrvirus-associatedcancersinchildren.Oncolo-gist,2003,8(1):83-98.4.SayosJ,WuC,MorraM,etal.TheX-linkedlymphoprolifera2tive-diseasegeneproductSAPregulatessignalsinducedthroughtheco-receptorSLAM.Nature,1998,395:462-469.5...,2003,18(1):61-36.6.KasaharaY,YachieA.CelltypespecificinfectionofEpstein-Barrvirus(EBV)inEBV-associatedhemophagocyticlympho2histiocytosisandchronicactiveEBVinfection.CritRevOncolHematol,2002,44(3):283-294.7.TaiebA,PlantinP,DuPasquierP,etal.Gianotti-Crostisyn-drome:astudyof26cases.BrJDermatol,1986,115(1):49-59.8.RickinsonAB.ChronicsymptomaticEpstein-Barrvirusinfec2tion.ImmunolToday,1986,7:13-14.9.KawaK.Epstein-Barrvirusassociateddisease.MinophagenMedRev,1999,44:1-13.10.NakagawaA,ItoM,SagaS.FatalcytotoxicT-cellproliferationinchronicactiveEpstein-Barrvirusinfectioninchild2hood.AmJClinPathol,2002,117(2):283-290.11.DaviF,DelecluseHJ,GuietP,etal.Burkitt-likelymphomasinAIDSpatients:characterizationwithinaseriesof103humanimmunodeficiencyvirus-associatednon-Hodgkinslymphomas.BurkittsLymphomaStudyGroup.JClinOncol,1998,16(12):3788-3795.12.AozasaK.Pyothorax-associatedlymphoma.IntJHematol,1996,65:9-16.13.Garcia-CosioM,SantonA,MendezMC,etal.Nasopharyngeal/nasaltypeT/NKlymphomas:analysisof14casesandreviewoftheliterature.Tumori,2003,89(3):278-284.14.LeeIS,KimSH,SongHG,etal.ThemolecularbasisforthegenerationofHodgkinandReed-SternbergcellsinHodgkin’slymphoma.IntJHematol,2003,77(4):330.(:2003-12-23)©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.