人工心脏发展中的关键技术

27120082BeijingBiomedicalEngineeringVo.l27No.1February2008:(50676044)(3072008):1(100084)2(100084):(1984),,,人工心脏发展中的关键技术李莹1段婉茹2罗先武1刘树红1张明奎2许洪元1,,,,,,;;R318.6A1002-3208(2008)01-0100-05KeytechnologiesfordevelopingartificialheartsLIYing1,DUANWanru2,LUOXianwu1,LIUShuhong1,ZHANGMingkui2,XUHongyuan11StateKeyLaboratoryofHydroscienceandEngineering,TsinghuaUniversity,Beijing100084;2MedicalSchool,TsinghuaUniversity,Beijing100084AbstractWiththespeedydevelopmentofmodernengineeringscienceandtechnology,theartificialhearthasbeenmuchimprovedasareplacementofhumanheartorabridgetohearttransplantation.Theirmechanicalandbiocompat-ibleperformancesbecomeobviouslybetter.Byfar,thoughamarkedtechnologydevelopmentofartificialhearthasbeena-chieved,therearestilllotsofproblemsfortheproductsandclinicalapplicationofartificialheart.Inthispaper,thedo-mesticandinternationalsituationforartificialheartresearchisanalyzed,andsomecrucialproblemsduringtheresearchandclinicalapplicationofartificialheartaresummarizedsoastoaffordreferencestosupportingthetechnologyimprovementandclinicalapplicationofartificialheart.Keywordsartificialheart;keytechnologies;engineeringscience,,:,,,,,,,,1660[1],[2]21,,;,,,,,,11812,LeGallois1937,JohnGibbon1957,WilliamKolffTetsuoAkutsu,[3],,,,(),,,,,BaxterHealthcareNovacor,,,,,,MicroMedDeBakeyVADJarvik2000VAD,theNimbus-TCIHearMtateIIVAD,,TerumoVADMedQuestHeartquestVAD,,,,VentraAssistNEDO,,,,,,,20013Novacor,,20034,[4],,,,,,2,,21,,,;[5,6]:,,;,,,,,,101122,:,,,Starling,,,,,[7],,,,232080,O,HIA-MedosAGDelta-Stream,,,7,,,[8,9],,,,,,3,31,,,:,,;,[10,11]:,,[12]San-droDeGruttolaCFD[13],,[14,15]PIV[16],[17,18][19][20]32,,,,10227,[21],,,,:,,,,,3320GerhardSchweitzer[22]2002,,,[23,24],,[25]34,[26],,(RBC)(HGB)(HCT)(FHB),(PLT)(LDH);,(BUN)(creatinine);,(bilirubin),,,,,,35,,[27],,4,,,,,,10,,,,,,,,,[1]AmericanMedicalAssociation,2002,Heartdiseaseandstrokesstatistics-2003Update.AmericanHeartAssociation,Dallas,TX.[2]MalcheskyPS.BloodPumpTechnology:ACrowdedArena?[J].ArtificialOrgans,2006,30(3):129-130.[3]OlsenDB.Presidentialaddress:thehistoryofcontinuousflowbloodpumps[J].ArtificialOrgans,2000,24(6):401-404.[4]..7.:2004-10-28.[5]ZhangJ,GellmanB,KoertA,eta.lComputationalandexper-i1031mentalevaluationofthefluiddynamicsandhemocom-patibilityofthecentrimagbloodpump[J].ArtificialOrgans,2006,30(3):168-177.[6].CFD[D].:,2003.[7]NishimuraT,TatsumiE,NishinakaT,eta.lDdiminishedvaso-constrictivefunctioncausedbylong-termnonpulsatileleftheartbypass[J].ArtificialOrgans,1999,23(8):722-726.[8]AsamaJ,ShinshiT,HoshiH,eta.lAcompacthighlyefficientandlowhemolyticcentrifugalbloodpumpwithamagneticallylev-itatedimpeller[J].ArtificialOrgans,2006,30(3):160-167.[9]YamaneT.Thepresentandfuturestateofnonpulsatileartificialhearttechnology[J].ArtificialOrgans,2002,5:149-155.[10],,,.XZ-[J].,2005,24(6):405-409.[11]ChristiansenS,Perez-BouzaA,ReulH,eta.lInVivoExper-imentaltestingofamicroaxialbloodpumpforrightventricularsupport[J].ArtificialOrgans,2006,30(2):94-100.[12]KimS,ChoY,HogenauerWN,eta.lAmethodofisolatingsur-facetensionandyieldstresseffectsinaU-shapedscanningcapi-llary-tubeviscometerusingaCassonmodel[J].Non-NewtonianFluidMech,2002,103:205-219.[13]SandroDeGruttola,KevinBoomsma,eta.lComputationalsimu-lationofanon-Newtonianmodelofthebloodseparationprocess[J].ArtificialOrgans,2005,29:949-959.[14]WuZ,GottliebR,BurgreenG,eta.lInvestigationoffluiddy-namicswithinaminiaturemixedflowbloodpump[J].Exper-imentsinFluids,2001,31:615-629.[15]ChoiY,NishinoK,KurokawaJ,eta.lPIVmeasurementofin-ternalflowcharacteristicsofverylowspecificspeedsem-iopenimpeller[J].ExperimentsinFluids,2004,37:617-630.[16]NishidaM,YamaneT,TsukamotoY,eta.lEffectofwashoutholegeometryonacentrifugalbloodpump[J].ASAIO,2000,46:172-178.[17].[D].:,2005.[18],,,.XZ-A[J].,2004,23(3):215-217.[19],,.[J].(),2005,45(5):704-707.[20].[D].:,2001.[21].[D].:,2004.[22]SchweitzerG.Safetyandreliabilityaspectsforactivemagneticbearingapplications-ASurvey[J].JournalofSystemsandCon-trolEngineering,Proc.oftheInstitutionofMechanicalEngineers(IMechE),PartI,2005,219(6):383-392.[23],,,.[J].,2001,20(4):342-345.[24],,,.[J].,2005,24(3):199-203.[25],,,.[J].(),2006,40(4):527-531.[26],,,.[J].,2002,21(2):155-160.[27]OzekiT,ChinzeiT,AbeY,eta.lPreliminarystudyofanewtypeofenergytransmissionsystemforartificialhearts[J].Artif-icialOrgans,2003,6:14-19.(2007-03-23)(52)[9]PritchardMT,WolfSF,KraybillWF,eta.lTheant-itumoreffectofinterleukin-12isenhancedbymild(fever-range)thermaltherapy.ImmunologicalInvestigations,2005,34(3):361-380.[10]CorryPM,DewhirstMW.Thermalmedicine,heatshockproteinsandcancer.IntJHyperthermia,2005,21(8):675-677.[11]StaufferPR.Evolvingtechnologyforthermaltherapyofcancer.IntJHyperthermia,2005,21(8):731-744.[12]HildebrandtB,Hegewisch-BeckerS,KernerT.Currentstatusofradiantwholebodyhyperthermiaattemperature41.5andpracticalguidelinesforthetreatmentofadults.IntJHyperther-mia,2005,21(2):169-183.[13]VertreesRA,LeethA,eta.lWhole-bodyhyperthermia:are-viewoftheory,designandapplication.IntJhyperthermia,2002,17(3):279-290.[14]HildebrandtB,LoffelJ,AhlersO,eta.lHype