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于韦韦张捷时淑珍【】。20111～2013422。40～60mg＜1.25m240mg1.25～1.5m250mg＞1.5m260mg14d21dPD。CＲ0PＲ7SD8PD7ＲＲ31.8%DCＲ68.2%PFS6.8。Ⅰ～Ⅱ°13.6%9%9%。、。【】ClinicalobservationofS-1asmaintenancetreatmentforadvancedbreastcancerYUWei-weiZHANGJieSHIShu-zhen．DepartmentofOncologyThirdPeople’sHospitalofDalianDalian116033China【Abstract】ObjectiveToobservetheclinicalefficacyandtoxicityofS-1asmaintenancetherapyinadvancedbreastcancer．MethodsＲetrospectivelyanalysis22patientswithadvancedbreastcancerwhowerereceivedfromJanuary2011toApril2013.TheyweregivenS-140～60mg＜1.25m240mg1.25～1.5m250mg＞1.5m260mgtwice/doraladministrationd1～d1421dayswasacycle．ＲesultsNumbersofcompleteresponsepartialresponsestablediseaseprogressiondiseaseofpatientswere078and7respective-ly．Of22patientstheＲＲwas31.8%theDCＲwas68.1%themedianPFSwas6.8months．Themostfre-quenttreatment-ralatedadverseeventsweremyelosuppressionnausealackofpower．ConclusionS-1asmain-tenancetreatmentforadvancedbreastcanceriseffectivewithminimaladversereactionsandcanbetoleratedbypatientssoitisworthyofclinicalpromotion．【Keywords】S-1ChemotherapyAdvancedbreastcancerEfficacy1。。20111～1160332013422。11.1①②IV③④6⑤ECOG≤2⑥⑦、。3X。1X3P＞0.053。66。。6。3。。1．．2013293217.2．．2013331155-156.3．．201227141289.·01·2014182ChinJModDrugApplJan2014Vol．8No．21.22235～6251.45913EＲ166PＲ148Her-261691317104311。1.340～60mg＜1.25m240mg1.25～1.5m250mg＞1.5m260mg。2ＲECIST。II°2。1.4ＲECIST1.12CＲ、PＲ、SD、PDCＲ+PＲＲＲCＲ+PＲ+SDDCＲ。WHO0～Ⅳ1。1.5PFS。201311。22.122274864811013.9。CＲ0PＲ7SD8PD7ＲＲ31.8%DCＲ68.2%PFS6.81PＲ1SD。2.2Ⅰ～ⅡIII。、。1。1n%ⅠⅡⅢⅣ627.2731.8290313.6418.1001986.42900418.1290029000522.7000、940.9313.60014.50003S-1FUtegafurFT、gimeracilCDPHoterecilpotassiumOXO。FT12h。CDPHFT。OXO3。1999、、、、4。Ⅱ。1086。103541.7%OS872d5。ShienT6S-1PＲ13%SD25%。710PＲ3。8、、PFS。。。。。1．．2013142-145425-449.2JulkaPKDovalDCGuptaSetal．ＲesponseassessmentinsolidtumoursacomparisonofWHOSWOGandＲECISTguidelines．BrJＲadiol200881966444-449.3ShirasakaTTsukudaMInuyamaYetal．NeworalanticancerdrugTS-1S-1frombenchtoclinic．GanToKagakuＲyoho2001286855-864.4．．200796499-502.5SaekiTTakashimaSSanoMetal．AphaseIIstudyofS-1inpatientswithmetastaticbreastcancer-aJapanesetrialbytheS-1CooperativeStudyGroupBreastCancerWorkingGroup．BreastCancer2004112194-202.6ShienTShimizuCAkashi-TanakaSetal．ClinicalefficacyofS-1inpretreatedmetastaticbreastcancerpatients．JpnJClinOncol2008383172-175.7．10．2001165524-526.8．．2013405481-484.·11·2014182ChinJModDrugApplJan2014Vol．8No．2