mTOR

ErkRSKPKCαRaptorRagA/BRagC/Dp70S6K4E-BP1IRS-1PTENPDK1PI3KLKB1AMPKAktGβLmTORmTORRictorSin1PRR5GβLSGK1TSC1ATG13RhebREDD1/2PRAS40HIF-1PGC-1αPPARγWntFrizzledLRPGαq/oDvlDEPTORDEPTORGSK-3TSC2FKBP12VEGF/AngiogenesisMitochondrialMetabolismAdipogenesisAminoAcidsHypoxiaPIP3PIP2AMP:ATPAICARmetforminAutophagymRNATranslationProliferationCellGrowthTranscriptionRibosomeBiogenesismTORC1mTORC2GrowthFactors,Hormones,Cytokines,etc.StressEnergyNutrientsrapamycinmTORSignaling©2008–2010CellSignalingTechnology,Inc.mTORSignaling•createdSeptember2008•revisedNovember2010DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKey©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase