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©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(100871),,,,,[1]1,MBH,,,1(a),M(B)H,,,H,Ms,,MH,MHH0,M0,MrM0,,Hc,M(Ms),0,,1(a),,,,,,,,,,1(b),0,Blocking,2,,,,,,1©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(Rsd),[2]:Rsd=36AK0M2s,A,K,Ms1(a);(b)2,,,,,2,,()2(W/O)(CVD)[3]LaMer[4],,,,,,3[5],,,,Ostwald,,,,2©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[5]3,,,0,[627],,,0,(Fe(CO)5),;(Co2(CO)8),Co,,2Co[8]1,22,Fe(CO)5Co2(CO)8FeCo[9],,,,,N2(Me3NO),,,Fe@Fe3O4[10],,,,()CoCl2,,2Co[8]FeSO4CoCl2,FeCo[11],,LiBEt3HFeCl2Pt(acac)24nmFePt[12]1,22,,,Fe(acac)3,418nmFe3O4[13],,MFe2O4,(M=Co,Mn),1,222Fe(acac)3Co(acac)2FeCo;20nmFeCoMs207cm3g-1,,,230cm3g-1[14],,3©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(380),,CCOH2,,,Fe3O4,710nm[15],,,,,,,[5]4,,,[16],Co,CoO2,300Fe(acac)3,FeO(4(a))[17],1,,,,(1),,,,FePt,20200nm(4(b))[18219];,,,,,,,,,22nmFe3O4(4(c),(d))[20]4(a)FeO,(b)FePt,(c,d)Fe3O44©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[21],,,,,,,,,,,[22],FePt,,FePtCdX(X=SorSe),FePt@CdX(5(a),(c))[23224],,FePt2CdX(5(b),(d)),FePtCdXCdX,FePt,,,5[23224](a)FePt@CdS,(b)FePt2CdS,(c)FePt@CdSe,(d)FePt2CdSe6,5©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[25],20nm,200800nm[26]7(MRI),[27],,,(1T),,,MRI,,,,,,,,7.1,,,,,,(),6,,(6(a)),,(6(b))Dai(PEG),FeCoMnO[28],,,PEG,2(PS2PAA),222[29],,,,Xu,,,,7[30]PEG,,6©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(a),(b)7Fe3O4[30]PEGFe3O4,(),[31],,,,2,2,32(DMSA)[32],PEG,,,,Xie,42(42MC),,[33],Mannich,(c(RGDyK)),v327.2MRI(MRI),,,((T1)(T2)),MR()7©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[3][3,5],MRI[34],12nmMnFe2O4110cm3g-1,12nmFe3O4CoFe2O4NiFe2O41019985cm3g-11.5T2(T2)2MRI,MnFe2O4,358Lmmol-1s-1,Fe3O4,CoFe2O4NiFe2O4218,172152Lmmol-1s-18Fe3O4MnFe2O4MRI,8,,,MnFe2O4,,,MnFe2O4(Herceptin),HER2/neu,,MnFe2O42Herceptin,MRI,,Fe3O42Herceptin,MnFe2O42HerceptinMR,,MRI,FeCor2644Lmmol-1s-1[35]8MnFe2O4Fe3O4MRI[34](a)MnFe2O4(50nm);(b)T2MR;(c)6nm,9nm12nmMnFe2O4;(d)r2,Fe3O4(10nm),4.5nmFe3O4,(c(RGDyK))[36],U87MGT22MRI,c(RGDyK)2Fe3O48©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(RGDyK)2Fe3O4r2165Lmmol-1s-1,(Feridex)(104Lmmol-1s-1)c(RGDyK)2Fe3O4,MR,c(RGDyK)(10mgkg-1),7.3,,,,,,,,,,APS,FITC,/MRI[37],T1,,TEOSAPSGd2O3,[38239],,,,,DOTA,,/,[40]CdSe,T1,CdSe,/MRI[41],,,Hyeon,[41],Fe3O4Au,,,SiO22Fe3O4@Au,,,CheonFePt,[42],FePt2Au,HmenB1,MRIHyeon,Fe3O4MnO[43],Au2Fe3O4,MRISun[44],,Fe3O4,;A431,Mou,Fe3O4@SiO2[45],FITC,Fe3O4@SiO22SiO2,9©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[46],Fe3O4,(SMCC),SiO2,,MRIHmenB1,CHP2134HEK293T,HaamFe3O4/[47],,Fe3O4MRI,Herceptin,,,PCL2PMMAMnFe2O4,(Cetuximab)[48]A431MCF7,EGFR,/MRIHyeon,(D,L222)(PLGA)Fe3O4[49],,,,8,;;MRI,[1]CullityBD.IntroductiontoMagneticMaterials.ReadingMA:Addison2WesleyPublishingCompany,1972[2]SkomskiR,CoeyJMD.PermanentMagnetism.BristolandPhiladelphia:InstituteofPhysicsPublishing,1999[3]FreyNA,PengS,ChengK,etal.ChemSocRev,2009,38:2532[4]LaMerVK,DinegarRH.JAmChemSoc,1950,72:4847[5]MurrayCB,KaganCR,BawendiMG.AnnuRevMaterSci,2000,30:545[6]HyeonT.ChemCommun,2003,927[7]CushingBL,KolesnichenkoVL,OConnorCJ.ChemRev,2004,104:3893[8]MurrayCB,SunS,DoyleH,etal.MRSBull,2001,26:985[9]HttenA,SudfeldD,EnnenI,etal.JMagnMagnMater,2005,293:93[10]PengS,WangC,XieJ,etal.JAmChemSoc,2006,128:10676[11]HuangJ,HeL,LengY,etal.Nanotechnology,2007,18:415603[12]SunS,AndersS,ThomsonT,etal.JPhysChemB,2003,107:5419[13]SunS,ZengH,RobinsonDB,etal.JAmChemSoc,2004,126:273[14]ChaubeyGS,BarcenaC,PoudyalN,etal.JAmChemSoc,2007,129:721401©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[15]XuZ,ShenC,HouY,ChemMater,2009,21:1778[16]KimD,ParkJ,AnK,etal.JAmChemSoc,2007,129:5812[17]HouY,XuZ,SunS.AngewChemIntEd,2007,46:6329[18]SunS,MurrayCB,WellerD,etal.Science,2000,287:1989[19]WangC,HouY,KimJ,etal.AngewChemIntEd,2007,46:6333[20]ZhangL,WuJ,LiaoH,etal.ChemCommun,2009,4378[21]GaoJ,GuH,XuB.AccChemRes,2009,42:1097[22]MichaletX,PinaudFF,BentolilaLA,etal.Science,2005,307:538[23]GuHW,ZhengRK,ZhangXX,etal.JAmChemSoc,2004,126:5664[24]GuHW,ZhengRK,LiuH,etal.Small,2005,1:402[25]HouY,GaoS,OhtaT,etal.EurJInorgChem,2004,1169[26]DengH,LiX,PengQ,etal.AngewChemIntEd,2005,44:2782[27]CorotC,RobertP,IdeeJM,etal.AdvDrugDeliveryRev,2006,58:1471[28]SeoWS,LeeJH,SunX,etal.NatMater,2006,6:971[29]KimSW,KimS,TracyJB,etal.JAmChemSoc,2005,127:4556[30]XuC,XuK,GuH,etal.JAmChemSoc,2004,126:9938[31]WangB,XuC,XieJ,etal.JAmChemSoc,2008,130:14436[32]JunYW,HuhYM,ChoiJS,etal.JAmChemSoc,2005,127:5732[33]XieJ,ChenK,LeeHY,etal.JAmChemSoc,2008,130:7542[34]LeeJH,HuhYM,JunYW,etal.NatMed,2007,13:95[35]SeoWS,LeeJH,SunX,etal.NatMater,2006,6:97