基因治疗现状与前景

基因治疗现状与前景作者：张夏华，吴广通，李蓉，ZHANGXia-hua，WUGuang-tong，LIRong作者单位：张夏华,吴广通,ZHANGXia-hua,WUGuang-tong(武警上海总队医院药剂科,上海,201103)，李蓉,LIRong(上海仁济医院五官科,上海,200001)刊名：药学实践杂志英文刊名：JOURNALOFPHARMACEUTICALPRACTICE年，卷(期)：2009，27(1)引用次数：0次参考文献(57条)1.TrackingGene-ModifiedTCellsInVivo20092.Gene-therapytrialstorestartfollowingcancerriskreview2005(7030)3.RetroviralGeneTransferintoPrimaryHumanNaturalKillerCells20094.Short-TermCultureofHumanCD34+CellsforLentiviralGeneTransfer20095.InSitu(InVivo)GeneTransferintoMurineBoneMarrowStemCells20096.Nonviralvectorsinthenewmillennium:deliverybarriersingenetransfer2001(8)7.DirectimmunizationofmalariaDNAvaccineintotheliverbygenegunprolectsaguinstlethalchallengeofPlasmodiumbergheisporozoite20008.张国华.谭小凡.沈冬.赵淑媛.时彦一.金彩科.孙惟谷.郭艳红.陈光慧.汤健肌肉电脉冲转移人α2干扰素基因的表达和抗肿瘤作用[期刊论文]-中国药理学报(英文版)2003(9)9.AsyringeelectrodedeviceforsimultaneousinjectionofDNAandelectrotransfer2002(3)10.LocaldeliveryofplasmidDNAintoratearolidarteryusingultrasound2002(10)11.HydrodynamicdeliveryofDNA2003(6)12.RNAinterferencetargetingFatsprotectsmicefromfulminanthepatitis2003(3)13.CharacteristicsandbiodistributionofcationicliposomesandtheirDNAcomplexes2000(1)14.StabilizationoflipidDNAcomplexesduringthefreezingstepofthelyophilizationprocess:theparticleisolationhypothesis2000(1-2)15.Improvementoftrans-ductionefficiencyofrecombinantadenovirusvectorconjugatedwithcationicliposomeforhumanoralsquamouscellcarcinomacellines2003(6)16.Preliminarycharacterizationofnovelaminoacidbasedpolymericvesiclesasgeneanddrugdeliveryagents2000(6)17.Preventionofautoimmuneinsulitisbydeliveryofachimericplaamidencodingintedeukin-4andinterleukin-102003(2)18.Differentbehaviorofbranchedandlinearpolyethylenimineforgenedeliveryinvitroandinvivo2001(4)19.Chitosanasanonviralgenedeliverysystem.Structure-propertyrelationshipsandcharueteristiescomparedwithpolyethylenimineinvitroandafterlungadministrationinvitro2001(14)20.IntravascularandendobronchialDNAdeliverytoroutinelungtissueusinganovel,nonvirulvector2000(10)21.SynthesisofhomogeneousglycopeptidesandtheirutilityasDNAcondensingagents2000(1-4)22.pH-sensitivecationicpolymergenedeliveryvehicle:N-Ac-poly(L-histidine)-grafi-poly(L-lysine)combshapedpolymer2000(5)23.常津.刘海峰.许晓秋.原续波.姚康德.尤永平.蒲佩玉一种新型纳米基因载体的制备及体外实验[期刊论文]-中国生物医学工程学报2002(6)24.AnonviralDNAdeliverysystembasedonsurfacemodifiedsilica-nanoparticlescanefficientlytransfectcellsinvitro2000(6)25.OpticaltrackingoforganicallymodifiedsilicananoparticlesasDNAcarriers:Anonviral,nanomedicineapproachforgenedelivery2005(2)26.Improvementoftransductionefficiencyofrecombinantadenovirusvectorconjugatedwithcationicliposemeforhumanoralsquamouscellcarcinomacelllines2003(6)27.Anovelnon-vlralgenetransfersystem,polycationliposomos2001(3)28.Suecessfultreatmentofroutinebeta-thalassemiaintermediabytransferofthehumanbeta-globingene2002(6)29.Correctionofsicklecelldiseaseintransgenicmousemodelsbygenetherapy2001(5550)30.NeurodeganerationpreventedbylentiviralvectordeliveryofGDNFinprimatemodelsofParkinson'sdisease2000(5492)31.Invivogenetherapyofmetachromaticleukodystrophybylentiviralvectors:correctionofneuropathologyandprotectionagainstlearningimpairmentsinaffectedmice2001(3)32.Characterizationof911:anewhelpercelllineforthetitrationandpropagationofearlyregion1-deletedadenoviralvectors1996(2)33.NovelcomplementationcelllinesderivedfromhumanlungcarcinomaA549cellssupportthegrowthofEl-deletedadenovirusvectors1996(1)34.High-capacity'gutless'adenoviralvectors2001(5)35.Helper-dependentadenovirusvectorselicitintactinnatebutattenuatedadaptivehostimmuneresponsesinvivo2004(11)36.Noveladeno-associatedvirusesfromrhesusmonkeysasvectorsforhumangenetherapy2002(18)37.Cloningandcharacterizatianofadeno-associatedvirustype51999(2)38.EvidenceforgenetransferandexpressionoffactorIXinhsemophiliaBpatientstreatedwithanAAVvector2000(3)39.Genedeliveryusingherpessimplexviresvectors2002(12)40.Replication-defectivegenomicherpessimplexvectors:designandproduction2002(5)41.HSV-1ampliconvectors-simplicityandversatility2000(1)42.novelanti-herpessimplexvirustype1-specificherpessimplexvirustype1recombinant1999(11)43.ATrans-DominantNegativeandReplicationDefectiveHSV-1VectorforInVivoandExVivoGeneTransfer2004(z1)44.Anoverviewofcurrentdeliverysystemsincancergenetherapy2004(1)45.Tropism-modifiedadenoviralandadenoassociatedviralvectorsforgenetherapy2002(3)46.Viralvectortargeting1999(5)47.Adenovirusvectorpseudotypinginfiber-expressingcelllines:improvedtransduetianofEpstcin-Barrvirus-transformedBcells2000(1)48.Ligand-directedtargetingofgenestothesiteofdisease2003(1)49.Adeno-associatedvirusserotypo8efficientlydeliversgenestomuscleandheart2005(3)50.Chinaapprovesfirstgenetherapy2004(1)51.Virotherapeuties:conditionallyreplicativeadenovirusesforviraloncolysis2003(8)52.TheADAhumangenetherapyclinicalprotocal:pointstoconsiderresponsewithclinicalprotecol199053.Tlymphocyte-directedgenetherapyforADA-SCID:initialtrialresultsafter4years1995(5235)54.Apilotstudyofinvivoliver-directedgenetransferwithanadenoviralvectorinpartialornithinetranscarbamylasedeficiency2002(1)55.Fatal