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/20119305JIntReprodHealth蛐FamPlanSeptember2011,Vol.30,No.5··polycysticovariansyndromePCOS。1935SteinLeventhal7、、、。。PCOS。3NationalInstitutesofHealthNIHNIH、EuropeanSocietyofHumanReproductionandEmbryologyESHREAmericanSocietyforReproductiveMedicineASRMAndrogenExcessSocietyAESAES。。NIH19904NIHPCOS[1]。NIHPCOS①。②。③△【】PCOS。PCOS。19353NIHNIHESHREASRMRotterdamAESAES。2011PCOS。。2008ESHREASRMPCOS。PCOSPCOS。【】DiagnosisCriteriaandGuidelinesfortheDiagnosisandTreatmentofPCOSCUILin-linCHENZi-jiang.CenterforReproductiveMedicineProvincialHospitalAffiliatedtoShandongUniversityNationalResearchCenterforAssistedReproductiveTechnologyandReproductiveGeneticstheKeyLaboratoryforReproductiveEndocrinologyofMinistryofEducationShandongProvincialKeyLaboratoryofReproductiveMedicineJinan250021ChinaCorrespondingauthorCHENZi-jiangE-mailchenzijiang@hotmail.com【Abstract】PolycysticovarysyndromePCOSisoneofthemostcommonendocrinalandmetabolicdiseasesinfertilewoman.TherearemanycontroversiesonPCOSdiagnosisbecauseofitsdiversityandheterogeneityinclinicalmanifestationsandthephenotypesoverlappingwithnormalindividuals.SincePCOSwasdescribedforthefirsttimein1935threeconsensuseshavebeenproposedsuccessively.TheyareNIHcriteriabyNationalInstitutesofHealthRotterdamcriteriabybothEuropeanSocietyforHumanReproductionandEmbryologyESHREandAmericanSocietyforReproductiveMedicineASRMandAEScriteriabyAndrogenExcessSociety.In2011“DiagnosiscriteriaforPolycysticOvarySyndrome”wasestablishedbyChineseMedicalAssociationwhichwassupportedbyMinistryofHealthofChina.ThisChinesecriteriawasbasedonthecurrentlyavailableevidencesinHanChinese.Thecontradictionsofdiagnosishaveinfluenceonthestandardizedtreatment.SofartheconsensusreachedbyPCOSConsensusWorkshopGrouponthetreatmentofPCOSinfertilityhasbeenwell-accepted.ThispaperdescribedthemaincriteriaofPCOSandtheconsensusonthetreatmentofPCOSinfertility.【Keywords】PolycysticovarysyndromeInfertilityfemaleDiagnosisTherapyCriteria（JIntReprodHealth蛐FamPlan，201130405-408）250021、、、△E-mailchenzijiang@hotmail.com405··/20119305JIntReprodHealth蛐FamPlanSeptember2011,Vol.30,No.5、Cushing、。。10NIH。NIHPCOSNIH。PCOS、、。2003ESHRE/ASRMPCOS[2]。PCOS———polycysticovaryPCO。PCOS、2。NIHPCOSPCOPCOS。、PCO。PCOSPCOS。NIHPCO。PCOS。PCOS。PCO。AESPCOS。NIH。AESMEDLINEPCOS[3]。PCOS。、PCOPCOS。PCO。PCOS。PCOSMetaPCOS。。、、。。2008“”201171201112。PCOS、[4]。PCOS、、。“PCOS”。、。21PCOS①。②PCO。PCOS。PCOS。PCOS3①。②、、。③PCOSPCOPCOSPCO。PCOSPCOS。“”。。PCOS。2008ESHRE/ASRMPCOS[5]PCOS。、PCOS。PCOS、、。。、、。PCOSclomiphenecitrateCC、laparoscopicovariansurgeryLOS。PCOS。5%、。、、。PCOS、406··/20119305JIntReprodHealth蛐FamPlanSeptember2011,Vol.30,No.5。。、CCCCPCOSPCOS。、、、、。CC--FSH。CCPCOS、、、。CC50mg/d2~5150mg/d。。CC75%~80%PCOS22%。CC66CC50%~60%。6FSHLOSCC。CC、、。CC。、。、。。PCOSBMI。CCCC。BMI＞35kg/m2CC。。PCOS。B。、CC。37.5~50IU/d6。14d50%。70%20%OHSS。OHSS。＞16mm＞3。＞14mm、≥4。＞14mm＞2＞10mm34。3＞14mm。E2ASRME22500ng/L。＜1000ng/L。hCG38hCG①≥16mm≥2。②≥16mm≥1≥14mm≥2。、LOSCCPCOSLOS。OHSS。、、。LOS①CCPCOS。②。③。④。4~10。50%。12CC6。、IVFIVF。PCOSIVF、、、IVF。MetaPCOSIVF、、。。。PCOS。PCOS。CCLOS。CC72％。IVF。PCOS、。。PCOS。PCOS。[1]ZawadskiJKDunaifA.Diagnosticcriteriaforpolycysticovary407··/20119305JIntReprodHealth蛐FamPlanSeptember2011,Vol.30,No.5p393p390programmereducestheriskofovarianhyperstimulationsyndromeinhighresponders[J].HumReprod1993881184-1186.[22]Schr觟derAKSch觟pperBAl-HasaniSetal.Unilateralfollicularaspirationandin-vitromaturationbeforecontralateraloocyteretrievalamethodtopreventovarianhyperstimulationsyndrome[J].EurJObstetGynaecolReprodBiol20031102186-189.[23]ZhuWJLiXMChenXMetal.Follicularaspirationduringtheselectionphasepreventssevereovarianhyperstimulationinpatientswithpolycysticovarysyndromewhoareundergoinginvitrofertilization[J].EurJObstetGynecolReprodBiol2005122179-84.[24].[J].2008106406-409.[25].B[J].201032145-46.[26]AgdiMZareiAAl-SannanB.Effectsofovarianpunctureforinvitromaturationonsubsequentinvitrofertilizationcycleinwomenwithpolycysticovarian[J].FertilSteril2010941381-383.[27]ZhuWFuZChenXetal.Transvaginalultrasound-guidedovarianinterstitiallasertreatmentinanovulatorywomenwithpolycysticovarysyndromearandomizedclinicaltrialontheeffectoflaserdoseusedontheoutcome[J].FertilSteril2010941268-275.[28]ApiM.Couldtransvaginalultrasound-guidedovarianinterstitiallasertreatmentreplacelaparoscopicovariandrillinginwomenwithpolycysticovarysyndromeresistanttoclomiphenecitrate?[J].FertilSteril20099262039-2040.2011-07-18[]X-chromosomeinfluencessusceptibilitytopolycysticovarysyndrome[J].JClinEndocrinolMetab20069172789-2791.[13]GrewalSIMoazedD.Heterochromatinandepigeneticcontrolofgeneexpression[J].Science20033015634798-802.[14]JiangBKennaHARasgonNL.GeneticoverlapbetweenpolycysticovarysyndromeandbipolardisorderTheendophenotypehypothesis[J].MedHypotheses2009736996-1004.[15]VriesLKarasikALandauZetal.Endocrineeffectsofvalproateinadolescentgirlswithepilepsy[J].Epilepsia2007483470-477.[16]MooreGEAbu-AmeroSNBellGetal.Evidencethatinsulinisimprintedinthehumanyolksac[J].Diabetes2001501199-203.[17]XitaNTsatsoulisA.Reviewfetalprogrammingofpolycysticovarysyndromebyandrogenexcessevidencefromexperimentalclinicalandgeneticassoci