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12120072JOURNALHARBINUNIV.SCI.&TECH.Vol112No11Feb.,2007D,L-,,(,150040):D,L-,,,8616%D,L-.D,L-.FT-IRDSC.,D,L-:125,,117%,,150,232.,,D,L-1251812714,5511%.:D,L-;;:O621.3:A:1007-2683(2007)01-0126-03SynthesisofD,L-lactideLIULi2zhu,FENGSong,MAHong2jie(MaterialScience&EngineeringCollege,HarbinUniv.Sci.Tech,Harbin150040,China)Abstract:D,L-lactidewaspreparedfromD,L-lacticacidwithzincacetateascatalyst,crudeyieldwas8616%.Effectsofdehydrationtimeandtemperatureoflacticacid,typeandamountofcatalystsoncrudeyieldoflactidewerestudied.ThesampleswerecharacterizedbymeansofFT-IRandDSC.Theresultsshowdedthattheoptimalconditionswereasfollows:atmosphericdehydrationtemperaturewas125,amountofzincacetatewas117%,vacuumdehydrationtemperaturewas150,depolymerizingtemperaturewas232.Ethanolwasanap2propriatesolventforrecrystallization,withwhichthemeltingrangeofD,L-lactidewas1251812714andthetotalyieldofpurifiedlactideincreasedto5511%afterthreerecrystallizations.Keywords:D,L-lactide;zincacetate;recrystallization:2006-09-12:(105HZ028).:(1964-),,.(PLA),,[1-4].PLA.PLA,.,,,(LA)[5-8].D,L-,,,.,5511%D,L-LA.1111D,L-,,;,,;,,;,,;,,;,,.EQUINOX55,KBr,5004000cm-1;PEPyrisDiamond,5/min,N2.11211211D,L-80%D,L-200mL.125,3h,,015210%.150,(01095MPa),3h,,D,L-D,L-.D,L-,D,L.180260.01095MPa,D,L.80%.11212D,L-,,215ml,,D,L-4524h.2211,,125,3h,,1503h,,90%,.,100,,,125,,3h.,,,1.,,,,01098MPa.1/()/()/(%)14023027265139691851502282328113486162160230235771267913517023427669132721651,150,,,.212.,,,125,30min,125150min,.,150,,,,,01098MPa.2,117%,.2/h/h/(%)04105413260135131575136821353310811348616253108019586189,,,,,3h.3h,3h.213,,117%,3.7211:D,L-3/()/(%)2432646418275167230235811348616224627848196581793,,,,.214015%,110%,115%,116%,117%,118%,119%,210%,1.,,,115%,.117%,,.110%,,.1215,,,,,,232,235,,,.216,,,4.41/()/mL/(%)672107216662157913872158115802158616,,,12616.217D,L-2,175118cm-1();2929199cm-1144814cm-1CH3;300918cm-1292919cm-1CH;1385119cm-1CH;126211cm-1109914cm-1COC,C=O;135315cm-1C;351512cm-1OH;2640101cm-1OH;93117cm-165213cm-1.2D,L-3D,L-DSC,D,L-1251812714.3D,L-DSC3:1253h1503h,,D,L-117%,;232,,80%,8616%.,215ml,,1251812714,(132)82112,;,,,,3%TiO2.5,,.:TiO2,,50100nm.TiO2,:TiO2TiO2,,.400,3%,,7315%.:[1],,,.TiO2[J].,1998,10(4):349-361.[2]FOXMA,DULAYMT.HeterogeneousPhotocatalysis[J].Chem.Rev.,1993,93(1):341-345.[3]HAGFELDTA,GRAETZELM.NanostructuredTiO2Semicon2ductorElectrodesModifiedwithSurfaceAttachedViologens:Ap2plicationsforDisplaysandSmartWindows[J].Chem.Rev.,1995,95(1):49-68.[4],,.TiO2[J].,2001,46(4):265-272.[5],.[J].,1999,11(1):1-10.[6]TRYK.DA,FUJISHIMAA,HONDAK.RecentTopicsinPho2toeletrocheMistry:AchievementsandFutureProspects[J].Elec2trochim.Acta,2000,45(15-16):2363-2376.[7]HOFFMANNMR,MARTINST,CHOIW,etal.EnvironmentalApplicationofSemiconductorPhotocatalysis[J].Chem.Rev.,1995,95(1):69-96.[8],,,.TiO2[J].,2003,20(1):73-76.(:)(128)50%,5511%.:[1]SUMINGL,MATHIEUT,HENRIG,etal.EnzymaticDegradationofEtereocopolymersDerivedfromL-,DL-andMeso-Lactide[J].PolymerDegradationandStability,2000,67:85-90.[2],.-[J].,1995,23(8):9-11.[3]MOEKS,WEISMANRA.ResorbableFixationinFacialPlasticandHeadandNeckReconstructiveSurgery:anInitialReportonPolylacticAcidImplants[J].Laryngoscope,2001,111(10):697-701.[4],.[J].,2005,24(6):183-193.[5],.[J].,1996,19(1):112.[6],,.[J].,2002,4:81.[7],,,.-[J].(),1999,16(2):96.[8],,,.[J].,2004,21(10):745.(:)23112