:2002-12-15:(1978-),,,,:,(,510515):,,,,,,:;;;:O613.52:B:1005-5320(2003)02-0052-05,0105%,,,,,1,,,(Se-Cys)(Se-Met),(GSHPx),Se,,[1]Se-Met,Se-Cys,2,(GSH-Px)GSH-Px,4(GSH-Px),,,GSH-PxH2O2,,1979Helmler[2],,,,,33,3.1:;();T(TThTsTc)(NK)K,,3TTcNKTc,IL2IL2T,T,3.2,B(),(),,,,IgGIgM,H.somus.3.3(),2520Vol.202No.2StudiesofTraceElementsandHealth20034Apr.2003©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.4[35]012110-6(15mg/70kg),,61%,,,GSH-Px,,,,,,,GSH-Px,,GSH-PxGSH-Px,100g/L140g/L,GSH-Px,GSH-Px,GSH-PxGSH-Px,GSH-Px2,GSH-Px20%GSH-Px,GSH-Px,100135ng/mlGSH-Px100120dGSH-Px,,,,GSH-Px,(100g/d),,(),24h,55.1[68](NK,)UGA,,,5.1.1EbolaEbola,;,,17UGA,5.1.2(HIV)UGA,HIVHIV,AIDSAIDS5.1.3(MMTV)MMTV,MMTVgagUGAMMTV5.2,,2070,,,,,,,,,[9,10],,[11,12]:(AHH),AFB1AFB13(PHGPx),,,cGMP,DNARNA5.33520Vol.202No.2StudiesofTraceElementsandHealth20034Apr.2003©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,:GPx;GPx4,;,,GPx,,,,,,,[13],,[14],,[15],,,5.4,:(CIC),CIC,C3b,95%,5001000[16]GPx,,,,,GPx,,C3b[17],,,[18],[19]5.5[2023]1957Schwarz,,GSHPx,LPO,,,,,5.6[2023],GSHPx,GSHPx(LPO),DNA,,GSHPx,LPO,,,5.7[2023],,,,5.8,,,,,,5.9,,Bar2rington3,GPxDNA:,,,,,,,,UrsinGPx4GPx450%,GPx4,5.10[27,28],,;,;,,4520Vol.202No.2StudiesofTraceElementsandHealth20034Apr.2003©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,,,,(,),,,15,//;,//,,5.11[2931],,GPx,,,GPx,,GPx,,,,,,,5.12,,7g[32],,GSHPxH2O223,1/6,,,,,(),,,,,,110-7210-6g310-6110-5g,110-5g,,6,,,,,,,,6.1[33,34](GSHPx),50g/d,50400g/dGSHPx,,GSHPx,80%,GSHPx30%,,GSHPx,GSHPx,,,,250g/d,400g/d,,750g/d,,10d,,,,,,80g/d,60g/d,,,6.2[35,36]()(),,50%100%,,GSHPx,,,,,,,,():/AEC:B6EB12:[1],.[J].5520Vol.202No.2StudiesofTraceElementsandHealth20034Apr.2003©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,2000,17(2):70-71[2],,.[J].,1995,16(2):53[3].[J].,1998,19(1):9-11[4]PaolaBorella,Annalisa,Bargellini.ChemicalFormofSe2leiumgreatlyaffectsmetaluptakeandrestonsesbycul2turedhumanlymphocytes.BiologicalTraceelementRe2search,1996,51:43-54[5]HawkesWC,HornbostelL.Effectsofdietaryseleniumonmoodinhealthymenlivinginhealthymenlivinginametabolicresearchunit.Bio.Psychiatry,1996,39(2):121-8[6]LevanderAetal.BiolTraceElemRes,1997,56:5-21[7]Ramanathametal.BiolTraceElemRes,1997,56:93-106[8]TaylorEWetal.JMedChem,1994,37:2637-2645[9],.[J].,1991,12(4):155[10].[J].,1995,16(3):111[11],.[J].,1994,21(2):139[12]Meyskens,JrFL.Micronutrients.In:DeVita,JrVT,Hellmans,RosenbergSA,eds.Cancer:Principle&Practiceofoncology.5thedit.NewYork:LippincottRaven,1997.573-579[13]KingJC.Effectsofreproductiononthebioavailabilityofcalcium,zincandselenium.JNutr,2001,131(supp1.4):1355s-1358s[14]MillerS,WalkerSW,ArthurJR,eral.Seleniteprotectshumanendothelialcellsfromoxidativedamageandin2ducesthioredoxinreductase,ClinSei,2001,100:543-550[15]TanguyS,BoucherF,BesseS,etal,Traceelementsandcardioprotection:increasingendogenousglutathioneper2oxidaseactivitybyoralscleniumsupplementationinratslimitsreperfusioninducedarrhythmias.JTraceElemMedBiol,1998,12:28-38[16].[J].,1990,11(3):382[17],,,.[J].,1993,14(3):234-236[18],.[J].,1992,21(10):589[19].[M]..:,1984.142-147[20].[J].,1999,(6):50-51[21].[M].:,1998.[22].[J].,1999,(2):91-84[23].[M].:,1994.[24]KingJC.Effectsofreproductiononthebioavailabilityofcalcinm,zincandselenium.Jnutr,2001,131(Supp1.4):1355-1358[25]BarringtonJW,TaylorM,SmithS,etal/Seleniumandrecurrentmiscarriage.JObstetGynaecol,1997,17:199-200[26]ScottR,MacphersonA.Seleniumsupplementaioninsub-fertilehumanmales.BrJUrol,1998,82:76-80[27]FinleyJW.PenlangJG.Adequacyordeprivationofdi2etaryseleniuminhealthymen;clinicalandpsychologicalfindings.JtraceElemExpMed,1998,11:11-27[28]BentonD.CookR.Seleniumsupplementationimprovesmoodinadouble-blindcrossovertrial.Biolpsychiatry,1991,29:1092-1098[29]OlivieriO.GirelliD.AzziniM,etal.Lowseleniumstatusintheelderlyinfluencesthyroidhormones.ClinSci,1995,89:637-642[30]KnektP,HeliovaaraM.AhoK.etal.Selenium,serumal2phatotocopherolandtheriskofrheumatoidarthritis,Epi2demiology,2000,11:402-405[31]mcCloyR.ChronicpancreatitisatManchester,UK:focusonantioxidanttherapy.Digestion,1998,59(Suppl.4):36-38[32].[J].,1998,13(4):34[33].[J].,1998,19(1):9-11[34],,.[J].,1996,15(1):7-9[35]PaolaBorella,AnnalisaBargellini.ChemicalFormofSele2niumgreatlyaffectsmetaluptakeandrestonsesbycul2turedhumanlymphocytes.BiologicalTraceelementRe2search,1996,51:43-54[36]HawkesWC,Hornbostell.Effectsofdietaryseleniumonmoodinhealthymenlivinginametabolicresearchunit.Biol.Psychiatry,1996,39(2):121-86520Vol.202No.2StudiesofTraceElementsandHealth20034Apr.2003©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.