Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety肠结核和结核性腹膜炎Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety肠结核定义:肠结核是结核分支杆菌感染引起的肠道慢性特异性感染性疾病,病变主要位于回盲部。临床上常有腹痛及腹部压痛、排便异常、腹部肿块和结核中毒症状。本病患者多为青壮年,20~40岁约占60~70%;女性多于男性,约呈3:1Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety(一)病因与发病机制致病菌–人型结核菌占绝大多数–牛型结核菌Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety感染途径(1)经口感染--主要途径•自身结核吞下带结核菌的痰•与肺结核病人共餐,吞下带菌食物•饮用结核杆菌污染的牛奶(2)血行播散:粟粒性肺结核,结核杆菌经血行播散至肠壁(3)直接蔓延:腹腔内邻近结核病灶(输卵管结核、肠系膜淋巴结核等)直接蔓延Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety类型:–溃疡性肠结核–增生型肠结核–混合性肠结核Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety(二)临床表现典型临床表现:腹痛排便异常腹部包块肠外结核的表现(全身症状)Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.InordertomeettheneedsofsocietyWiththeimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.InordertomeettheneedsofsocietyWiththeimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety3、腹部肿块主要见于增生型肠结核也可见于溃疡型肠结核和周围组织粘连,或并有肠系膜淋巴结核等,均可形成肿块而被扪及。腹块常位于右下腹,中等硬度,可有轻、中度压痛,有时表面不平,移动度小、边缘不甚规则、表面不平。Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety4、全身症状和肠外结核的表现溃疡型肠结核:常有结核毒血症,如午后低热,伴有盗汗,乏力,消瘦,贫血等症状和体征。增生型肠结核多无结核中毒症状,病程较长,全身情况较好。Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety5、并发症(1)肠梗阻:最常见,主见增生型原因:肉芽组织增生溃疡瘢痕收缩(2)肠出血:少见(3)肠穿孔Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety(三)辅助检查(1)实验室检查血常规:贫血,WBC正常,淋巴细胞↑血沉ESR:明显↑结核菌素试验:强阳性粪便检查常规:糊状、少量WBC、RBC病原:结核杆菌(+)Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety(2)X线检查钡餐透视—首选溃疡型:激惹征象—跳跃征增生型:肠腔狭窄充盈缺损Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety(3)结肠镜检查临床意义:有确诊价值镜下表现:肠粘膜充血、水肿环绕肠周溃疡(边缘呈鼠咬状)炎性息肉肠腔狭窄组织学检查:干酪性肉芽肿结核杆菌溃疡肉芽肿Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety(四)治疗要点1、抗结核药物治疗(1)用药原则:早期、适量、规律、联合、全程。(2)联合用药:三或四联,疗程:6~9月(3)用药方法:同肺TBWiththeimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety2、对症治疗(1)休息:活动性者:卧床休息(2)饮食:高营养、富含维生素、易消化不能进食者:静脉高营养(3)支持治疗:给予阿托品等抗胆碱能药物缓解腹痛;纠正水、电解质与酸碱失衡;不完性肠梗阻时可行胃肠减压Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety3、手术治疗①急性肠穿孔②完全性肠梗阻③肠道大量出血内科积极抢救不能止血者④肠瘘内科治疗未能闭合者Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety结核性腹膜炎Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety结核性腹膜炎定义:结核性腹膜炎是由结核分枝杆菌感染引起的腹膜慢性弥漫性炎症。发病情况:我国常见病之一,中青年多见,女性多见,男女比1:2。Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety(一)病因及发病机制病因:由结核分枝杆菌感染腹膜引起。感染途径:直接蔓延为主肠系膜淋巴结结核、卵巢输卵管结核、肠结核为常见原发病。血行播散少见活性肺结核,关节、骨、睾丸结核等。并可伴结核性多浆膜炎、结核性脑膜炎。Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety病理本病病理特点:渗出、粘连、干酪三型,前两型多见,粘连型最多,其次为渗出在本病的发展过程中可两型或三型病变并存,称为混合型。Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety1、症状:(1)全身症状:结核中毒症状发热和盗汗。低热或中度发热为主,1/3可有驰张热,少数稽留热。后期营养不良(消瘦、疲乏、浮肿、贫血、舌炎、口角炎等)。(二)临床表现Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety(2)腹痛:早期腹痛不明显,以后持续性隐痛或钝痛,少数也可无腹痛出现。部位在脐周、下腹,有时全腹。当发生肠梗阻时,可出现阵发性绞痛。(二)临床表现Withtheimprovingqualityoflifeaswellastheever-acceleratingpaceoflife,thequalityofpeople'sfoodneedsandratealsochanging.Inordertomeettheneedsofsociety(3)腹泻:腹泻常见,3~4次/日。呈糊样。原因与腹膜炎所致的肠功能紊乱有关;部分病人有腹泻及便秘交替。(4)可伴有腹胀。