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:,100037;;PossibilityofcirrhosisoflivertreatedbybonemarrowstemcelltransplantationKeywordsHematopoieticstemcell;Cirrhosisofliver;TherapyFirstauthorsnameandaddressSUNTao,DigestiveDepart2mentofNavyGeneralHospital,Beijing100037,China:R575.2:A:1006-5709(2006)04-0336-03,,,,,,,,,,,,,,?,,,,;,Hering,;,,,[1],,,(replicativesenescence)[2,3],(Hematopoi2eticstemcell,HSC)(mesenchymalstemcell,MSC),(transdifferentiation),,,,Thy21CD34CD45Sca21C2kitFlt23Peterson[4],:,22AAF,Y;,;L2126BrownNorwayL2126Lewis,L2126,,,Theise[5]Y,,(4%43%),,,,(sidepopulation),23ABCG2/BCRP1(adenosinetriphosphate2bindingcassettetransporterABCG2/BCRP1),[6],,,:,,,Hering;,,,,[7]Austin[8],(HSC)(fumarylace2toaeetoacetatehydrolasen,FAH),63320068154ChinJGastroenterolHepatol,Aug2006,Vol.15,No.4,22,30%,,,,HSC;[9],,,,,,,YannakiE[10]ki267SryCCl4,G2CSF,,Ki267(+)/Sry(-),Ki267(+)/Sry(+),,,,,,,,,,,(HGF)(TGF2TGF2)(FGF);,;;TGF2,HGF,,2SMA,,[11](EGF)22(22acetylaminofluorene,22AAF),TNFIL26,22AAF,TNF,,,,,Theise[12]CD34+Lin2,YmRNA,28,0.39%1.1%,,1%3.6%,,4%43%AlisonKorbling[13,14],0.5%2%4%7%,,,YannakiE[10],(G2CSF),,,,,Fang[15]CCl4,CCl4FLKl(+),TGF22SMA,,,,,,,,,;,;;,,/,,,,,,,,,,,73320068154ChinJGastroenterolHepatol,Aug2006,Vol.15,No.4,,,,,,,,[1]LowesKN,CroagerEJ,OlynykJK,etal.Ovalcell-mediatedliverre2generation:Roleofcytokinesandgrowthfactors.JGastroenterolHepatol,2003,18(1):4212.[2]FalkowskiO,AnHJ,IanusIA,etal.RegenerationofHepatocytebudsincirrhosisfromintrabiliarystemcells.JHepatol,2003,39(3):3572364.[3]WiemannSU,SatyanarayanaA,TsahuriduM,etal.Hepatocytetelomereshorteningandsenescencearegeneralmarkersofhumanlivercirrhosis.FASEBJ,2002,16(9):9352942.[4]PetersenBE,BowenWC,PatreneKD,etal.Bonemarrowasapotentialsourceofhepaticovalcells.Science,1999,284(5417):116821170.[5]TheiseND,NimmakayaluM,GardnerR,etal.Liverfrombonemarrowinhumans.Hepatology,2000,32(1):11216.[6]ShimanoK,SatakeM,OkayaA,etal.HepaticoralcellshavethesidepopulationphenotypedefinedbyexpressionofATP2bindingcassessetetrans2porterABCG2/BCRP1.AmJPathol,2003,163(1):329.[7]SellS,Heterogeneityandplasticityofhepatocytelineagecells.Hepatology,2001,33(3):7382750.[8]AustinTW,LagasseE.Hepaticregenerationfromhematopoieticstemcells.MechDev,2003,120(1):1312135.[9]RudnickiMA.Marrowtomuscle,fissiznversusfusion.NatMed,2003,9(112):14621462.[10]YannakiE,AthanasionE,XagorattiA,etal.G2CSFprimedhematopoi2eticstemcellsorG-CSFperseacceleraterecoveryandimprovesurvivalafterliverinjury,predominanfiybypromotingendogenousrepairprograms.Hemato1,2005,33(1):1082119.[11]KimWH,MatsumotoK,BesshoK,etal.Growthinhibitionandapoptosisinlivermyofibroblastspromotedbyhepatocytegrowthfactorleadstoreso2lutionfromlivercirrhosis.AmJPatho1,2005,166(4):101721028.[12]TheiseND,BadveS,SaxenaR,etal.Derivationofhepatocytefrombonemarrowcellsinmiceafterradiation2inducemyeloablation.Hepatology,2000,31(1):2352240.[13]AlisonMR,PoulsomR,JefferyR,etal.Hepatoeytesfromnon-hepaticadultstemcells.Nature,2000,406(6793):257.[14]KorblingM,KatzRL,KhannaA,etal.Hepatocytesandepithelialcellsofdonororigininrecipientsofperipheral2bloodstemcells.NEnglJMED,2002,346(10):7382746.[15]FangB,ShiM,LiaoL,etal.SystematicinfusionofFLKI(+)mes2enchymalstemcellsamelioratecarbontetrachloride2inducedliverfibrosisinmice.Transplatation,2004,78(1):83288:2006201220(335)[24]SerakinciN,GuldbergP,BurnsJS,etal.Adulthumanmesenchymalstemcellasatargetforneoplastictransformation.Oncogene,2004,23(29):509525098.[25]RubioD,Garcia2CastroJ,MartinMC,etal.Spontaneoushumanadultstemcelltransformation.CancerRes,2005,65(11):303523039.[26]XuW,QianH,ZhuW,etal.Anoveltumorcelllineclonedfrommutat2edhumanembryonicbonemarrowmesenchymalstemcells.OncolRep,2004,12(3):5012508.[27]BurnsJS,AbdallahBM,GuldbergP,etal.Tumorigenicheterogeneityincancerstemcellsevolvedfromlong2termculturesoftelomerase2immortal2izedhumanmesenchymalstemcells.CancerRes,2005,65(8):312623135.[28]Valk2LingbeekME,BruggemanSW,vanLohuizenM.Stemcellsandcancer;thepolycombconnection.Cell,2004,118(4):4092418.[29]LiangZ,WuT,LouH,etal.InhibitionofbreastcancermetastasisbyselectivesyntheticpolypeptideagainstCXCR4.CancerRes,2004,64(12):430224308.[30]LydenD,HattoriK,DiasS,etal.Impairedrecruitmentofbone2marrow2derivedendothelialandhematopoieticprecursorcellsblockstumorangio2genesisandgrowth.NatMed,2001,7(11):119421201.[31]RodriguezMdelC,BernadA,AracilM.Interleukin26deficiencyaffectsbonemarrowstromalprecursors,resultingindefectivehematopoieticsup2port.Blood,2004,103(9):334923354.[32]TohK,KukitaT,WuZ,etal.PossibleinvolvementofMIP21alphaintherecruitmentofosteoclastprogenitorstothedistaltibiainratswithadjuvant2inducedarthritis.LabInvest,2004,84(9):109221102.[33]El2OmarEM,RabkinCS,GammonMD,etal.Increasedriskofnoncar2diagastriccancerassociatedwithproinflammatorycytokinegenepolymor2phisms.Gastroenterology,2003,124(5):119321201.[34]Janowska2WieczorekA,MarquezLA,NabholtzJM,etal.GrowthfactorsandcytokinesupregulategelatinaseexpressioninbonemarrowCD34(+)cellsandtheirtransmigrationthroughreconstitutedbasementmembrane.Blood,1999,93(10):337923390.[35]WangT,XiaD,LiN,etal.Bonemarrowstromalcell2derivedgr