根皮苷药效作用研究进展_袁鑫

510006、、、、、。Ｒ285．5Ｒ282．71Adoi10．3969/j．issn．1006-8783．2015．06．0311006-8783201506-0833-04ProgressonthepharmacologicaleffectsofphloridzinYUANXinHOUShaozhenLAIXiaopingSchoolofTraditionalChineseMedicineGuangzhouUniversityofTraditionalChineseMedicineGuangzhou510006ChinaAbstractPhloridzinbelongingtoflavonoidshasavarietyofbiologicalactivitiessuchasloweringbloodglucoseimprovingmemoryanti-oxidationandanti-cancer．Inthispaperwereviewrecentprogressofphloridzinonitspharmacologicaleffectsondiabetesdiabetessyndromeandotherdiseaseswhichwillprovideanevidenceforthefuturestudy．Keywordsphloridzindiabetesdiabetessyndromepharmacologyeffect2015-07-27813032812012B0911001842012A1-AFD015141Z02031991—[e-mail]1983—[e-mail]。2015-10-191552http//．cnki．net/kcms/detail/44．1413．r．20151019．1552．006．htmlphloridzinphlorizin1-2-beta-D-46--C21H24O10436．4111。1835Petersen．C100、、、2。、、、3-5。。1Figure1Strutureofphloridzin11．1糖尿病(diabetesmellitus，DM)-JournalofGuangdongPharmaceuticalUniversityDec2015316SGLT6。Najafian7STZⅠWistar5、10、2040mg/kg。“、”。Zhao8-1MKＲmice、、、、MKＲmice。Masumoto9STZ5%ＲT-PCＲSTZSglt1、Cyp2b10Ephx1Glut2。1．2糖尿病综合征1．2．1糖尿病视网膜病变DMDM。1DM2DMDM10。Zhang11C57BLKS/Jdb/db2C57BLKS/Jdb/mdUTPiTＲAQLC-MS/MSWesternblotting。db/dbmice。1636348602733、、。。1．2．2糖尿病肾病30%～40%12。13、、、、。14、。Na+-SGLT1/SGLT2GLUT215。Na+-。Pei16。db/db、2。1214279。1．2．3糖尿病心肌病变17。Cai18iTＲAQdb/db10、。、。22．1肝脏疾病、、、。19LO2。O。、TG。LO2。Deng20CCl4SD、、、。HA、TGF-β1、43831AST、ALT、MDAGSH-Px、T-SOD。ＲT-PCＲα-SMA、TGF-β1、TIMP1mＲNAMMP1mＲNA。CCl4CCl4。CCl421。2．2骨质疏松、、、、22。23。Wang24、。Puel25。2．3衰老。26。。27。、、SOD、GSH-Px、CATMDA。Vasantha28VitE。Lan29SODSir2。30、、MDA2．0、5．0mg/mLP＜0．05。2．4中波紫外线(ultravioletB，UVB)导致的皮肤损害UVB。。Zhai31HaCaTcellUVBＲOSUVBUVB。UVB。3。、。。、、、、。。。1GOSCHCHALBWIＲTHHSTICHK．PhloridzinbiosynthesisdistributionandphysiologicalrelevanceinplantsJ．Phytochemistry2010718/9838-843．2PETEＲSENC．AnalysedesPhloridzinsJ．AnnalesAcadSciFranc1835151783．J．200612192-195．4．5386．J．20093019279-282．5EHＲENKＲANZJＲLLEWOSNGＲONNALDKCetal．PhlorizinareviewJ．Diab/MetabＲesＲev200521131-38．6．J．2013398182-184．7NAJAFIANMJAHＲOMIMZNOWＲOZNEJHADMJetal．Phloridzinreducesbloodglucoselevelsandimproveslipidsmetabolisminstreptozotocin-induceddiabeticratsJ．MoleculBioＲep20123955299-5306．8ZHAOHongYAKAＲSGAVＲILOVAOetal．Phloridzinimproveshyperglycemiabutnothepaticinsulinresistanceinatransgenicmousemodeloftype2diabetesJ．Diabetes200453112901-2909．9MASUMOTOSAKIMOTOYOIKEHetal．DietaryphloridzinreducesbloodglucoselevelsandreversesJ．JAgriculFoodChem200957114651-4656．10．J．200554755-759．11ZHANGShiyangLIBaoyingLIXiaolietal．Effectsofphlorizinondiabeticretinopathyaccordingtoisobarictagsforrelativeandabsolutequantification-basedproteomicsindb/dbmiceJ．MolVis201319812-821．12LAMBEＲSHEEＲSPINKHJZEEUWD．Thekidneyintype2diabetestherapyJ．ＲevDiabStud201183392-402．13DＲONAVALLISDUKAIBAKＲISGL．ThepathogenesisofdiabeticnephropathyJ．NatClinPractEndocrinolMetab200848444-452．14KOYADHAYASHIKKITADAMetal．Effectsofantioxidantsindiabetes-inducedoxidativestressintheglomeruliofdiabeticratsJ．JAmSocNephrol20031483S250-S253．15VESTＲISOKAMOTOMMDEFＲEITASHSetal．ChangesinsodiumorglucosefiltrationratemodulateexpressionofglucosetransportersinrenalproximaltubularcellsofratJ．JMembrBiol20011822105-112．16PEIFeiLIBaoyingZHANGZhenetal．Beneficialeffectsofphlorizinondiabeticnephropathyindiabeticdb/dbmiceJ．JDiabComp2014285596-603．17．J．201530187-89．18CAIQinLIBaoyingYUFeietal．Investigationoftheprotectiveeffectsofphlorizinondiabeticcardiomyopathyindb/dbmicebyquantitativeproteomicsJ．JDiabＲes2013201-9．19．LO2J．2015262144-147．20DENGGaigaiWANGJunzhiZHANGQiaoyingetal．Hepatopro-tectiveeffectsofphloridzinonhepaticfibrosisinducedbycarbontetrachlorideagainstoxidativestress-triggereddamageandfibrosisinratsJ．BiolPharmBull20123571118-1125．21．CCl4J．201026547-49．22LEONGKH．Medicaltreatmentofosteoporosis—increasingoptionsJ．AnnAcadMedSingapore200231143-47．23．J．201534281-86．24WANGJunzhiCHUNGMihwaXUEBingjieetal．EstrogenicandantiestrogenicactivitiesofphloridzinJ．Bio＆PharmBull2010334592-597．25PUELCQUINTINAMATHEYJetal．PreventionofbonelossbyphloridzinanapplepolyphenolinovariectomizedratsunderinflammationconditionsJ．CalcifTissueInt2005775311-318．26．2013J．201333225505-5506．27．J．20143515221-225．28VASANTHAＲHYASMINA．Inhibitionofoxidationofaqueousemulsionsofomega-3fattyacidsandfishoilbyphloretinandphloridzinJ．Molecules2010151251-257．29XIANGLanSUNKaiyueLUJunetal．Anti-agingeffectsofphloridzinanapplepolyphenolonyeastJ．BiosciBiotechBiochem2014755854-858．30．J．2015367167-171．31ZHAIYimiaoDANGYongyanGAOWenkeetal．P38andJNKsignalpathwaysareinvolvedintheregulationofphlorizinagainstUVB-inducedskindamageJ．ExpDermatol2015244275-279．(责任编辑:王昌栋)FDAVonvendiFDA2015128Vonvendi·vonWillebrandfactorVWF18。·vonWillebranddiseaseVWD1926EricvonWillebrand。1001。、、、。VonvendiBaxaltaU．S．Inc．FDA。FDA2015-12-863831