搜索
174199610()JournalofJinanUniversity(MedicineEdition)Vol.17No.4Oct.19966(M6PR)()黄行许1) 朴英杰1) 霍霞1) 唐珊珊2)(1)第一军医大学电镜室 510515,广州;2)华南农业大学动物医学系 510642,广州)M6PR(6),M6P(6),transM6PRM6PM6PR,M6PR,pH,,,M6PR,M6PR[34]1CI-M6PRCD-M6PRM6PR,M6PR,M6PR215,000,215-KDaM6PR,CI-M6PR21,27]M6PR46,00046-KDaM6PR,,CD-M6PR[5,6],,CD-M6PR[9]2M6PRcDNAM6PR,CI-M6PR7500,2500,4[12],4:44,2269,2316315147,,16%38%,,,19[7]CD-M6PRcDNA280,4[2],4:28;159;25,67CD-M6PR5M6PR[22],M6PR[1],CD-M6PR131137[32]M6PR,CD-M6PRCI-M6PR,14%28%,,13,,[2]:1995-08-253M6PRCD-M6PR,,[24,25]CD-M6PRM6P0.5,M6PM6P[29,30]CI-M6PR[24,25],CI-M6PR2M6P1CI-M6P15M6P[30]M6PRM6P,710-6810-6molCI-M6PRCD-M6PR(210-9210-7mol)M6PRM6PR,M6PM6PR,,CD-M6PR,CI-M6PR[29,30]M6PR,pH67,pH6,pH5.3-5.5,M6PR,M6PR[5]4M6PRM6PR,M6PM6PR,CD-M6PR,;CI-M6PR,,;CD-M6PRCI-M6PR[18,26]M6PRcDNAM6PR[13]CI-M6PR,CD-M6PR,CD-M6PR[27]Morgan[15],CI-M6PRIGF-(),M6PRIGF-/M6P,CI-M6PRM6PIGF-,[11,27,31](M6PRIGF-[3])M6PRM6PIGF-,IGF-M6PCI-M6PRIGF-,M6PR[20]M6PCI-M6PR,IGF-M6PRM6PRGTPGTP[16],CI-M6PRIGF-CI-M6PRIGF-[10],IGF-CI-M6PR[11]5M6PRM6PRCI-M6PRM6PR,trans,M6PRM6PRM6PR,M6PR,[4,8,18],,M6PR,M6PRM6PR[14],CI-M6PR17,CI-M6PRmRNACI-M6PR[28],CD-M6PR6[13]20d,M6PR158()1996,CI-M6PRCI-M6PRmRNA:[19]CI-M6PR,,mRNA[33],M6PR,IGF,M6PR,M6PR,CI-MPRIGF,M6PR1ConibearE,PearsBM.Achimeraofthecytoplasmictailofthemannose6-phosphate/IGFreceptorandlysosomallocalizestotheTGNratherthanprelysosomeswherethebulkoftheendogenousreceptorsfond.JCellSci,1994,107(4):9232DahmsCG,LobalPB,ReitmeyerJ,etal.46KDmannose6-phosphatereceptor;cloning,expression,andhomologytothe250kDamannose-phosphatereceptor.Cell,1987,50:1813DamsNM,BrzychiWessellMA,RamanujamKS,etal.Characterizationofmannose6-phosphatereceptors(MPRs)fromopossumliver:OpossumcationindependentMPRbindsinsulin-likegrowthfactor-.Endocrinology,1993,133(2):4404DuncaJR,KornfeldS.Intracellularmovementoftwomannose6-phosphatereceptors:Returntothegolgiapparatus.JCellBiol,1988,106:6175HoflackB,KornfeldS.LysosomalenzymesbindingtomouseP388D,macrophagemembraneslackingthe215kDamannose6-phosphatereceptor:Evidencefortheexistenceofasecondmannose6-phos-phatereceptor.ProcNatlAcadSciUSA,1985a,82:44286HoflackB,KornfeldS.Purificationandcharacterizationofacationdependentmannose6-phosphatere-ceptorfrommurineP388Dmacrophageandbovineliver.JBiolChem,1985b,260:120087HynesR.Molecularbiologyoffibronectin.AnnRevCellBiol,1985,1:678JinM,SahagianGG,SniderMD.Transportofsurfacemannose6-phosphatereceptortotheGolgicomplexinculturedhumancells.JBiolChem,1989,264:76759JunghansU,WaheedA,vonFiguraK.Thecationdependentmannose6-phosphatereceptorbindslig-andsintheabsenceofdivalentcations.FEBSLetters,1988,237:8110KiessW,HaskelJF,Lee,L,etal.Anantibodythatblocksinsulin-likegrowthfactor(IGF)bindingtothetypeIGFreceptorisneitheranagonistnoraninhibitorofIGF-stimulatedbiologicresponsesinL6myoblasts.JBiolChem,1987,262:1274511KiessW,ThomasCL,GreensteinLA,etal.Insulin-likegrowthfactorinhibitsboththeuptakeof-galactosidaseandthebindingof-galactosidasetopurifiedIGF/mannose6-phosphatereceptor.JBiolChem,1989,264:471012LobelP,DahmsNM,BreitmeyerJ,etal.Cloningofthebovine215-kDacation-dependentmannose6-phosphatereceptor.ProNatlAcadsciUSA,1987,84:223313LudwigT,RutherU,MetzgerR,etal.Geneandpseudogeneofthemousecation-dependentmannose6-phosphatereceotor.Genomicorganization,expression,andchromosomallocalization.JBiolChem,1992,267(17):122111594:6(M6PR)()14MatovcilLM,GoodhouseJ,FarquharMG,etal.Therecyclingitineraryofthe46kDamannose6-phosphatereceptorGolgi-tolateendosomes-coincideswiththatof215kDaM6PR.EurJCellBiol,1990,53(2):20315MorganDO,EdmenJC,StandingDN,etal.Insulin-likegrowthfactorreceptorasamultifunc-tionbindingprotein.Nature1987,329:30116MurayamaY,OkamotoT,OgataE,etal.Distinctiveregulationofthefunctionallinkagebetweenthehumancationindependentmannose6-phosphatereceptorandGTP-bindingproteinbyinsulin-likegrowthfactorandmannose6-phosphate.JBiolChem,1990,265(29):1745617NishimotoI,HataK,OgataE,etal.Insulin-likefactorstimulatescalciuminfluxincompetentBALB/C3T3cellsprimedwithepidermalgrowthfactor.Characteristicsofcalciuminfluxandinvolv-mentofGTP-bindingprotein.JBiolChem,1987,262:1212018NolanCM,GreekKE,GrubbJ,etal.Antibodytothephosphomannosy1receptorinhib-itsreceptorrecyclinginfibroalasts.JCellBiol,1987,35:13719OurslerMJ,RiggsBL,SpelsbergTC,etal.Glucocorticoid-inducedactivationoflatenttranceform-inggrowthfactorbedabynormalhumanosteoblast-likecells.MolReprodDev,1993,35(4):40820RogersSA,HammermanMR.Mannose6-phosphatepotentiatesinsulin-likegrowthfactorstim-ulatedinositoltriphosphateproductininproxmaltubularbasolateralmembrenes.JBiolChem,1989,264:427321SahagianGC,DistlerG,JourdianGW.Characterizationofamembrane-associatedreceptorfrombovineliverthatbindsphosphomannosylresiduesofbovinetesticular-galactasidase.ProAcadSci.USA,1981,78:428922SahagianGC,SteerCJ.Transmembraneorientationofthemannose6-phosphatereceptorinisolatedclathrin-coatedvesicles.JBiolChem,1985,260:983823SteinerAW,RomeLH.Assayandpurificationofasolubilizedmembranereceptorthatbindsthelyso-somalenzymesL-iduronidaseArchBiolchemBiophys,1982,284: