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©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(,130062):Q255:A:100725038(2000)0420005204:,,,;,:,,:;;;,,,;,,,[15]:2000204224:(39970566):(1954),,,,,,,,,1(Apoptosis,APO),,(Pro2grammedcelldeath,PCD),,,Apoptosis;,,:,,animal4thCongressofEurop[J].Asso.forVetPharmacolToxicol.Budapest,Hungary,1988.[26]MitemaES,SangiahS,MartinT.Effectsofsomecalciummodulatorsonmonensintoxicity[J].VetHumToxicol,1988,30(50:409413.[27]VanderkopPA,MacneilJD.Protectionprovidedbysodiumseleniteagainstanoraltoxicdoseofmonesininbroilerchicks[J].CanJAnimSci,1989,69:477482.[28]NikolovI,SimeonovS,IordanovV.Diagnosisandtreatmentofacutemonensinpoisoninginpigs[J].VeterinarnaSbirka,1987,85(3):1819.ReviewofthetoxicityofPolyetherIonophoricAntibioticsYANGGui2xiang,CHENZhang2liu(DepartmentofVeterinaryMedicineSouthChinaAgriculturalUniversity,Guangzhou510642,China)Abstract:Thetoxicityofionophoricantibiotics,theincompatibilitybetweenionophoresandantimicrobials,themechanismandtreatmentofionophorepoisoningwerereviewedinthispaper.Keywords:polyetherionophoricantibiotics;toxicity;mechanismandtreatmentofpoison2ing.5:©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(Activecellsuicide)1965Kerr[6]Kerr,,14,,,,,,,,,,Kerr,,,,,,,,,,,Kerr,1972,,,,21972,[711],,:,,,,,,(Apoptoticbody),,,,,,[12,13],DNA,DNA(1)DNA,(2)DNA,200BP,,(Ladder)(3)DNA,,,(4)DNA,DNA,(5)DNA,(AO),3(Necrosis),[1416],,,:,,,,,,62000214(112)©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:,,,,,,,,,,,,,,,,,,,,,,,;,,;,,:(1)(Pyknosis),(2)(Karyorrhexis),,,,(3)(Karyolysis)DNA,,,,,,4,,,,,:1,,,,,,,,DNADNADNA,:[1]MarianneauP,CardonaA,EdelmanL,etal.DenguevirusreplicationinhumanhepbatomacellsactivatesNF2kappaBwhichinturninducesapoptoticcelldeath[J].JVirology.1977,(71)4:32443249.[2]GomezVJC,BautistaMJ,CarrascoL,etal.Throm27:©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[J].JComPath,1998,(118)1:113.[3],.[J].,1997,24(10)429431.[4],,.[J].,1998,18(1):7678.[5],.[J].,1998,25(9):392394.[6]KerrJFR,WyllieAH,CurrieAR.Apoptosis:Abasicbiologicalphenomenonwithwideningimplica2tionsintissuekinetics[J].BrJCancer,1972,26:239257.[7]WyllieAH,KerrJFR,CurrieSR.Celldeath:thesignificanceofapoptosis[J].TntRevCyt,1980,68:251306.[8]WyllieAH.Anewclassificationseparatingapopto2sisfromnecrosis[M].London:ChapmanandHall.1981.934.[9]SenS.Programmedcelldeath:Concept,mechanismandcontrol[J].BioRevCambPhilsSoc,1992,67(3):287319.[10]TanimuraN,SharmaJM.In2situapoptosisinchickensinfectedwithinfectiousbursaldiseasevirus[J].JcomPath,1998,118(1):1527.[11]IharaT,SugamataM,SekijimaM,etal.ApoptoticcellulardamageinmiceafterT22toxin2induceda2cutetoxicsis[J].Natural2Toxins,1997,(5)4:141145.[12]WyllieAH.Apoptosis[J].BrJCancer,1993,67:205208.[13]EllisRE,YuanJY,HornitzHRR.Mechanismsandfunctionofcelldeath[J].AnnuRevCellBiol,1991,7:663667.[14]JubbKVF,PeterCK,PalmerN.PathologyofDo2mesticAnimals[J].AcademicPresINC,1985,3:915.[15],,.[M].:,1996.11(2):7477.[16].[M].:,1998.9(2):5360.ResearchRrogressbetweenApoptosisandCellularNectosisPANYao2qian,GAOFeng,CHENGJun(FacultyofAnimalMedicineQuartermasterUniversityofPLA,Changchun130062,China)Abstract:Thispapermakeacomparisonofpathogenesisandpathomorphologybetweenapoptosisandcellularnecrosis.Apoptosisisanactivedeathofcell.Itscharacteristicchangesaremonocellularoccurrence,pyknosis,karyorrhexisandtheformationofapoptoticbody.Thechangesoforganellesaremainlyatrophiclesions.Thecellularnecrosisisapassivedeath.Itatrophiclesions.Thecellularnecrosisisapassivedeath.Itoftenhappensinmanycells.Thecellularcharacteristiclesionsareswelling,nuclearfragmentationandlysis.Thisisainflam2matoryreactionsurroundingthenecrosis.Itisconsideredthattheparenchymaofapoptosisandcellularnecrosisisidenticalinthedegenerationchangesthoughtherearesomedifferenceinthepathogenesisandpathomorphology.Keywords:apoptosis;cellularnecrosis;pathogenesis;pathomorphology82000214(112)