白癜风发病机制研究进展-周晖

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E-mailxingqi.zhang@hotmail.com··510080。、-、、、。。R758.4+1A1674-8468201202-0111-03vitiligo、。0.5%~1%1。、-、、。。1。6.25%~40%182。。3、、。3。2-、、、4。。2.1TNF-α、IL-1β、IL-6、IL-85-67Th1789。、10-119。2.2。50%~93%1112012419212CD8+TT4。“”“”1-。3、、13。67-。reactiveoxygenspeciesROS14。-ROS1。44.1dUTPTdT-mediateddUTPnickendlabelingTUNELSmyth15。B-2B-celllymphoma2Bcl-2Bcl-2。16。。4.2melanocytorrhagy24、。、17。Koebner“”“”。5、、。、、、18。。19。19。。1GuerraLDellambraEBresciaSetal.Vitiligopatho-211JDiagnTherDermato-VenereolApr.2012.Vol.19No.2genetichypothesesandtargetsforcurrenttherapiesJ.CurrDrugMetab2010115451-467.2SehgalVNSrivastavaG.Vitiligocompendiumofclini-co-epidemiologicalfeaturesJ.IndianJDermatolVene-reolLeprol2007733149-156.3SpritzRA.RecentprogressinthegeneticsofgeneralizedvitiligoJ.JGenetGenomics2011387271-278.4LePooleICLuitenRM.Autoimmuneetiologyofgener-alizedvitiligoJ.CurrDirAutoimmun200810227-243.5KimNHTorchiaDRouhaniPetal.Tumornecrosisfactor-alphainvitiligodirectcorrelationbetweentissuelevelsandclinicalparametersJ.CutanOculToxicol2011303225-227.6BirolAKisaUKurtipekGSetal.IncreasedtumornecrosisfactoralphaTNF-alphaandinterleukin1al-phaIL1-alphalevelsinthelesionalskinofpatientswithnonsegmentalvitiligoJ.IntJDermatol2006458992-993.7KotobukiYTanemuraAYangLetal.DysregulationofmelanocytefunctionbyTh17-relatedcytokinessignifi-canceofTh17cellinfiltrationinautoimmunevitiligovul-garisJ.PigmentCellMelanomaRes2012252219-230.8WangCQCruz-InigoAEFuentes-DuculanJetal.Th17cellsandactivateddendriticcellsareincreasedinvitiligolesionsJ.PLoSOne201164e18907.9TaiebA.VitiligoasaninflammatoryskindisorderatherapeuticperspectiveJ.PigmentCellMelanomaRes20122519-13.10ParsadDKanwarA.Oralminocyclineinthetreatmentofvitiligo———apreliminarystudyJ.DermatolTher2010233305-307.11ZailaieM.Aspirinreducesserumanti-melanocyteanti-bodiesandsolubleinterleukin-2receptorsinvitiligopa-tientsJ.SaudiMedJ20052671085-1091.12KempEHGavalasNGGawkrodgerDJetal.Autoanti-bodyresponsestomelanocytesinthedepigmentingskindiseasevitiligoJ.AutoimmunRev200763138-142.13GlassmanSJ.VitiligoreactiveoxygenspeciesandT-cellsJ.ClinSciLond2011120399-120.14Dell’AnnaMLOttavianiMAlbanesiVetal.Mem-branelipidalterationsasapossiblebasisformelanocytedegenerationinvitiligoJ.JInvestDermatol200712751226-1233.15WangXErfGF.ApoptosisinfeathersofSmythlinechickenswithautoimmunevitiligoJ.JAutoimmun200422121-30.16MorettiSFabbriPBaroniGetal.Keratinocytedys-functioninvitiligoepidermiscytokinemicroenvironmentandcorrelationtokeratinocyteapoptosisJ.HistolHis-topathol2009247849-857.17KumarRParsadDKanwarAJ.Roleofapoptosisandmelanocytorrhagyacomparativestudyofmelanocytead-hesioninstableandunstablevitiligoJ.BrJDermatol20111641187-191.18LanWJWangHYWeiLetal.Evidencethatgenipo-sideabrogatesnorepinephrine-inducedhypopigmentationbytheactivationofGLP-1R-dependentc-kitreceptorsig-nalinginmelanocyteJ.JEthnopharmacol20081181154-158.19SchallreuterKUBahadoranPPicardoMetal.Vitiligopathogenesisautoimmunediseasegeneticdefectexces-sivereactiveoxygenspeciescalciumimbalanceorwhatelseJExpDermatol2008172139-140141-160.2011-09-29櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆櫆2012-03-15、20119《2011》0.46。。、31120124192

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