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Ｒ373．2A1008-8199201503-0225-04210002、。、、、、、。22、4、5、121。2“”142。200120081222013“333”。145SCI216024。NorovirusNoV90%1。NoV。NoV。1NorovirusNoV1．11972。。2002NoVNoV2。1．2NoV27～40nm18090。NoV3。1．3NoV、pH2．73h、4℃20%18～24h60℃30min。NoV3．75～6．25ppmCl－Cl－10ppm30min4－5。1．4NoVＲNA7．5kb。3openreadingframeOＲFs5'3'OＲF1、OＲF2OＲF3。OＲF2OＲF3VP1VP2VP1OＲF16p48、NTP、p22、VPg、Pro、Pol。NoVVP1GⅠ、GⅡ、GⅢ、GⅣ、GⅤ、GⅥGⅠ、GⅡGⅣNoV6。GⅠGⅡ922。22．1NoV。、、7－13。1993－2011NoV90014。NoV14。NoV·522·20153283JMedPostgraVol．28No．3March2015DOI:10.16571/j.cnki.1008-8199.2015.03.001、、、、、NoV15－21。。2006－2013NoV56497989NoV22。NoV23－24。2．2NoVNoV、。225。NoV100。1～3d105～1011。2．3NoV、。25。NoV、、、、、、25。1996－2000348NoV、39%、12%3%NoV26。2．4NoV、、25。2006NoVB27。NoV590＞6NoV110021．828。2009－20122522．61%52/230224。20116201355NoV10．9%29。2006－20135NoV200711．2%201120．3%22NoV。2．5NoVGII．4。NoV1～3“”NoV30－32。NoVGII．495/96US14。FarmingtonHills_2002Hunter_2004Yerseke_2006aDenHaag_2006bNewOrleans_2009Sydney_20127。NoV。62004－2012DenHaag_2006b20052008214。NoVHunter_2004DenHaag_2006bNewOrleans_2009。2010－2013Sydney_201233。NoVGII．12/GII．3。NoV。3NoV。24～48h12h72h。、、、34。NoV、＜102932。、、、、NoV25。800NoV90%6535。NoV。4NoV4．1＞106mL26。。·622·20153283JMedPostgraVol．28No．3March20154．2、-。。-NoV。90．91%～96．37%43．81%～97．14%36。4．3ＲT-PCＲ、NoVNoVPCＲ、。ＲT-PCＲNoVＲT-PCＲＲT-PCＲＲT-PCＲ。ＲT-PCＲNoV、37。ＲT-PCＲＲT-PCＲ。ＲNANoVＲT-PCＲＲNA38。5NoV5．1NoV①NoV22NoV。②22NoV。③NoV、22。5．2①。②。③22。5．3①、。、、、。②NoV、NoV。、、。③NoV、、、。6NoV。NoV、NoV。NoVNoV。NoV、、。【】1GlassＲIParasharUDEstesMK．NorovirusgastroenteritisJ．NEnglJMed2009361181776-1785．2MayoMA．AsummaryofraxonomicchangesrecentlyapprovedbyICTVJ．ArchVirol200214781655-1656．3HardyME．NorovirusproteinstructureandfunctionJ．FEMSMicrobiolLett200525311-8．4DuizerEBijkerkPＲoekxBetal．InactivationofcalicivirusesJ．ApplEnvironMicrobiol20047084538-4543．5DolinＲ．Noruviruses-challengestocontrolJ．NEnglJMed2007357111072-1073．6KarstSMZhuSGoodfellowIG．ThemolecularpathologyofnorovirusesJ．JPathol20152352206-216．7ZhouXLiHSunLetal．EpidemiologicalandmolecularanalysisofawaterborneoutbreakofnorovirusGII．4J．EpidemiolInfect2012140122282-2289．8LarssonCAnderssonYAllestamGetal．EpidemiologyandestimatedcostsofalargewaterborneoutbreakofnorovirusinfectioninSwedenJ．EpidemiolInfect20141423592-600．9VegaEBarclayLGregoricusNetal．GenotypicandepidemiologictrendsofnorovirusoutbreaksintheUnitedStatesJ．JClinMicrobiol2014521147-155．10FiorettiJMBelloGＲochaMSetal．TemporaldynamicsofnorovirusGII．4variantsinBrazilbetween2004and2012J．PLoSOne2014·722·20153283JMedPostgraVol．28No．3March201593e92988．11LopmanBAAdakGKＲeacherMHetal．TwoepidemiologicpatternsofnorovirusoutbreakssurveillanceinEnglandandwales1992-2000J．EmergInfectDis20039171-77．12MansJMurrayTYTaylorMB．NovelnorovirusrecombinantsdetectedinSouthAfricaJ．VirolJ201411168．13LimKLEdenJSOonLLetal．MolecularepidemiologyofnorovirusinSingapore2004-2011J．JMedVirol201385101842-1851．14MatthewsJEDickeyBWMillerＲDetal．TheepidemiologyofpublishednorovirusoutbreaksareviewofriskfactorsassociatedwithattackrateandgenogroupJ．EpidemiolInfect201214071161-1172．15．J．2014416991-993．16．2006-2007J．20083456-913．17．J．201424192887-2888．18．J．2014301103-104．19．J．201410301121-1123．20．J．2007287667-670．21．J．2014313250-252．22．J．2014297516-521．23．654J．2014244556-558．24．J．201424142011-2013．25SinghSK．ViralinfectionsandglobalchangeM．JohnWiley＆SonsInc2014517-553．26ThorntonACJennings-ConklinKSMcCormickMI．NorovirusesagentsinoutbreaksofacutegastroenteritisJ．DisasterManagＲesponse2004214-9．27TsengFCLeonJSMacCormackJNetal．MolecularepidemiologyofnorovirusgastroenteritisoutbreaksinNorthCarolinaUnitedStates1995-2000J．JMedVirol200779184-91．28PatelMMWiddowsonMAGlassＲIetal．SystematicliteraturereviewofroleofnorovirusesinsporadicgastroenteritisJ．EmergInfectDis20081481224-1231．29．5J．2014184336-339．30LindesmithLCDonaldsonEFLobueADetal．MechanismsofGII．4noroviruspersistenceinhumanpopulationsJ．PLoSMed200852e31．31MartellaVMediciMCDeGraziaSetal．EvidenceforrecombinationbetweenpandemicGII．4norovirusstrainsNewOrleans2009andSydney2012J．JClinMicrobiol201351113855-3857．32DonaldsonEFLindesmithLCLobueADetal．NoroviruspathogenesismechanismsofpersistenceandimmuneevasioninhumanpopulationsJ．ImmunolＲev2008225190-211．33LuQBHuangDDZhaoJetal．AnincreasingprevalenceofrecombinantGIInorovirusinpediatricpatientswithdiarrheaduring2010-2013inChinaJ．InfectGenetEvol201531C48-52．34DivisionofViralDiseasesNationalCenterforImmunizationandＲespiratoryDiseasesCentersforDiseaseControlandPrevention．Updatednoro-virusoutbreakmanagementanddiseasepreventionguidelinesJ．MMWＲＲecommＲep201160ＲＲ-31-18．35HallAJCurnsATMcDonaldLCetal．TheＲolesofClostridiumdifficileandNorovirusAmongGastroenteritis-AssociatedDeathsintheUnitedStates1999-2007J．ClinicalInfectiousDiseases2012552216-223．36．J．2010202453-455．37ＲohayemJBergerSJuretzekTetal．Asimpleandrapidsingle-stepmultiplexＲT-PCＲtodetectNorovirusAstrovirusandAdenovirusinclinicalstoolsamplesJ．JVirolMethods2004118149-59．38．ＲT-LAMP-J．20144152790-2799．2015-02-25·822·20153283JMedPostgraVol．28No．3March2015