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J．200931131258-1260.14．J/CD．201046411-444.15．26J．2005252231-233.16．-11J．2010264653-654.17．-M//．．2004182-190.18．2800J．2011169700-704.19．J．2011434544-547.2014-02-272014-11-26LncＲNAmiＲNA1△2※1.2100002.210000Ｒ73A1006-2084201509-1594-03doi10.3969/j.issn.1006-2084.2015.09.022BK2012872H201207ＲNALncＲNA。LncＲNAＲNAＲNAmiＲNA。miＲNALncＲNAmiＲNALncＲNA。miＲNALncＲNAmiＲNALncＲNA。ＲNAＲNAStudyontheInfluenceofInteractionbetweenLncＲNAandmiＲNAandTheirＲegulatoryMecha-nismsontheFormationandProgressionofTumorＲUIQiang1HEZhen-yu2.1.TheSecondClinicalCollegeofNanjingMedicalUniversityNanjing210000China2.DepartmentofGeneralSurgeryTheSecondAffliatedHospitalofNanjingMedicalUniversityNanjing210000ChinaAbstractAsoneoftheimportantregulatorymoleculesinhumangenomelongnoncodingＲNALn-cＲNAcandevelopitsbiologicalregulatoryfunctioninvariousaspects．StudiesofrecentyearshaveshownthatLncＲNAcaninteractwithmiＲNAasakindofcompetitiveandendogenousＲNAandtheycanpartici-pateinthetargetedgeneregulationtogetherwhichhasimportantinfluenceontheformationandprogressionoftumor．MeanwhilemiＲNAcanalsomaketargetedregulationoftheexpressionofLncＲNAwithalargea-mountofproteinencodinggenesbothmiＲNAandLncＲNAsplayimportantrolesintheregulationofcellularprocesses．BesidesthefunctionsofmiＲNAandLncＲNAhereistomakeareviewoftheinfluenceofinterac-tionbetweenmiＲNAandLncＲNAaswellastheirregulatorymechanismsontheformationandprogressionoftumor．KeywordsShortnoncodingmiＲNALongnoncodingＲNAInteractionsＲegulatorymechanismsＲNAmicrononcodingＲNAmiＲNAＲNAlongnoncodingＲNALncＲNA。LncＲNALncＲNALncＲNA1-2。LncＲNA3。miＲNALncＲNA。1LncＲNALncＲNA2004。55sense、antisense、bidirectional、intronicintergenicLncＲNA。LncＲNA。1.1ＲNAncＲNA6、ＲNAⅡDNA。ncＲNA。ncＲNA、、7。ncＲNAEvfDlx2。SEＲ38LncＲNASＲG1SＲG13'SＲG1SEＲ3。LncＲNA。·4951·20155219MedicalＲecapitulateMay2015Vol.21No.9ncＲNA9。ＲNATLSD1cAMP-responseelementbindingproteinCＲEBp300。5'LncＲNATLSD1。1.2ncＲNAＲNAⅡ10。ncＲNAＲNA-DNAⅡD。。1.3LncＲNALncＲNAmＲNAＲNAmＲNApre-mＲNA、、、、11。1.4LncＲNAmＲNA。LncＲNAmＲNAZeb2。Zeb2mＲNA5'UTＲ125'UTＲ。5'。。LncＲNAMALAT1pre-mＲNApre-mＲNA。1.5LncＲNAncＲNAmＲNA13。ＲNAⅢBC1BC200ncＲNAs。BC114。BC1D2。1.6LncＲNAＲNAsmallinterferingＲNAsiＲNALncＲNAsiＲNA15。siＲNAendo-siＲNA。1.7LncＲNALncＲNA、Ash1HoxUbx16HoxHoxncＲNAＲNA。2miＲNAmiＲNAＲNA17。miＲNA、、miＲNA、、。JiaＲock18。480miＲNAmiＲNA123miＲNA。miＲNAmiＲNAmiＲNA、。miＲNAmiＲNAmiＲNA。miＲNA。3IncＲNAmiＲNA3.1miＲNALncＲNAＲNAmiＲNALncＲNAs19。miＲNALncＲNAs。miＲNAmiＲNALncＲNAs20。Zhang21miＲ-21LncＲNA。83LncＲNAsLncＲNA-ArraymiＲ-21LncＲNA5growtharrest-specifictranscript5GAS5。miＲ-21GAS5。GAS5miＲ-21。GAS5miＲ-21GAS5-siＲNAmiＲ-21。miＲ-21GAS54miＲ-21。22GAS5。GAS5-ＲNAＲNAＲISCAGO2miＲ-21GAS5-ＲISCmiＲ-21GAS5mＲNAmicroＲNA。miＲ-21LncＲNAGAS5。3.2LncＲNAmiＲNAlncＲNAmiＲNA23-24lncＲNAmiＲNA3①LncＲNAmiＲNAmＲNA3'-UTＲmiＲNA。Pang25βLncＲNABACE1ＲNAＲNABACE1mＲNAmiＲNABACE1②LncＲNAmiＲNA·5951·20155219MedicalＲecapitulateMay2015Vol.21No.9miＲNA③LncＲNAmiＲNAmiＲNA26。LncＲNA。LncＲNALncＲNA27。LncＲNA。LncＲNA-MIAT28。LncＲNAＲNA。DNA、ＲNA、。LncＲNA、、29。LncＲNA。4miＲNALncＲNAsmiＲ-21LncＲNAGAS5LncＲNAmiＲNALncＲNA。LncＲNA。1YinZGuanDFanQetal．LncＲNAexpressionsignaturesinresponsetoenterovirus71infectionJ．BiochemBiophysＲesCommun20134302629-633.2HanLZhangKShiZetal．LncＲNAprofileofglioblastomare-vealsthepotentialroleofLncＲNAsincontributingtoglioblastomapathogenesisJ．IntJOncol20124062004-2012.3HuangJFGuoYJZhaoCXetal．HepatitisBvirusXproteinHBx-relatedlongnoncodingＲNALncＲNAdown-regulatedexpressionbyHBxDrehinhibitshepatocellularcarcinomametas-tasisbytargetingtheintermediatefilamentproteinvimentinJ．Hepatology20135751882-1892.4GongCPoppMWMaquatLE．Biochemicalanalysisoflongnon-codingＲNA-containingribonucleoproteincomplexesJ．Methods201258288-93.5SteckEBoeufSGablerJetal．ＲegulationofH19anditsenco-dedmicroＲNA-675inosteoarthritisandunderanabolicandcata-bolicinvitroconditionsJ．JMolMed201290101185-1195.6ZhuLXuPC．DownregulatedLncＲNA-ANCＲpromotesosteoblastdifferentiationbytargetingEZH2andregulatingＲunx2expres-sionJ．BiochemicalandBiophysicalＲesCommun20134324612-617.7SantoroFMayerDKlementＲMetal．ImprintedIgf2rsilencingdependsoncontinuousairnLncＲNAexpressionandisnotrestrictedtoadevelopmentalwindowJ．Development201314061184-1195.8YamaguchiAAbeM．Ｒegulationofreproductivedevelopmentbynon-codingＲNAinArabidopsisToflowerornottoflowerJ．JPlantＲes20121256693-704.9UvaPDaSaccoLDelCornoMetal．Ｒatmir-155generatedfromtheLncＲNABicis'hidden'inthealternategenomicassemblyandrevealstheexistenceofnovelmammalianmiＲNAsandclustersJ．ＲNA2013193365-379.10SantoroFPaulerFM．SilencingbytheimprintedAirnmacroLncＲNAtranscriptionistheanswerJ．CellCycle2013125711-712.11BhartiyaDKapoorSJalaliSetal．ConceptualapproachesforLncＲNAdrugdiscoveryandfuturestrategiesJ．ExpertOpinionDrugDiscov201276503-513.12BroadbentKMParkDWolfAＲetal．AglobaltranscriptionalanalysisofPlasmodiumfalciparummalariarevealsanovelfamilyoftelomere-associatedLncＲNAsJ．GenomeBiol2011126Ｒ56.13SatiSGhoshSJainVetal．Genome-wideanalysisrevealsdistinctpatternsofepigeneticfeaturesinlongnon-codingＲNAlociJ．NucleicAcidsＲes2012402010018-10031.14CabiancaDSCasaVGabelliniDetal．Anovelmolecularmecha-nisminhumangeneticdiseaseADNArepeat-derivedLncＲNApoint-of-viewJ．ＲNABiol20129101211-1217.15DingJLuQOuyangY