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Recordsidentifiedthroughdatebasesearching(n=317)Pubmed:74Embase:100Cochranelibrary:5Biosispreviews:135CBMdisc:2ClinicalTrials.gov:1Recordsafterduplicatesremoved(n=272)Recordsscreened(n=272)Fulltextsexcluded(n=12),withreasons-notRCTorCCT-notkneejointRecordsexcluded(n=253),withreasons-animalexperiment-invitrostudy-casereport-meetingabstract-reviewFulltextsassesedforeligibility(n=19)Studiesincludedinquantitativesynthesis(n=7)