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判断题：1.防腐剂的用量应尽量控制在产生抑菌作用的最低有效浓度（）2.苯甲酸尼伯金乙酯在酸性环境中，抑菌效果较差················（）3.O/W型乳剂应选择W/O型乳化剂······································（）4.静脉用或背椎腔用注射剂和眼外伤用的眼用制剂可以添加抑菌剂。···················································································（）5.当药液中含有营养性物质(如糖类、蛋白质、氨基酸、淀粉等)时，通常不宜只用一种防腐剂。···········································（）6.苯甲酸与尼伯金乙酯混合液的抑菌效果明显低于苯甲酸，尼伯金乙酯单用。·······································································（）7.在达到润滑细的前提下，润滑剂的用量原则上愈少愈好。····（）8.润滑作用与润滑剂的比表面积有关，一般固体润滑剂应愈细愈好。················································································（）9.不同软膏基质中的药物吸收速度为：水溶性基质＞O/W型乳剂基质＞W/O型乳剂基质。·····················································（）10.油脂性基质适宜用于急性具有多量渗出渗的皮肤疾病。······（）11.选用与药物溶解行为相反的栓剂基质有利于药物从基质中释放，增加药物吸收····························································（）12.水溶性基质做成的滴丸应选用水溶性冷凝液·····················（）一、名词解释1.药用辅料2.昙点3.HLB4.CMC二、单项选择题1.毒性大，为人体致癌物或环境危害物，一般严禁使用的溶剂，按毒性分类为哪类溶剂···························································（）A．引一类B．第二类C．第三类D．第四类E．第五类2.对于提取药材中有效成分所用的溶剂，以及存在最差制中的溶剂，下列说法正确的是························································（）A．禁止使用第三类溶剂B．避免使用第三类溶剂C．禁止使用第四类溶剂D．国际上通用第一类溶剂E．禁止使用第一类溶剂3.主要用作注射用无菌粉末的赋形和溶剂或注射剂的稀释剂的是（）A．饮用水B．蒸馏水C．注射用水D．灭菌注射用水E．去离子水4.可作为配制普通药物制剂的溶剂或试验用水，不得用于注射剂的配制的是····································································（）A．自来水B．纯化水C．注射用水D．灭菌注射用水E．井水5.在水中不离解，毒性和溶血性较小，目前应用最广，可用于内服，外用，注射等剂型的表面活性剂是··································（）A．阴离子型B．阳离子型C．两性离子型D．非离子型E．以上都不是6.海藻糖在药物制剂中常用作···········································（）A．冻干填充剂B．冻干保护剂C．渗透压调节剂D．增溶剂E．乳化剂7.适用于各种给药途径，应用最广泛的成膜材料是················（）A．白及胶B．壳聚糖C．聚乙烯酶D．明胶E．聚维桐8.栓剂的油脂性基质常用·················································（）A．甘油明胶B．氢化菎麻油C．可可豆脂D．白蜡E．蜂蜡9.滴丸水溶性基质常用····················································（）A．聚乙二酶B．硬脂酸C．单硬脂酸甘油酯D．氢化植物油E．虫蜡10.滴丸制备时常用的冷凝液有··········································（）A．甘油B．明胶C．二甲基硅油D．丙二酶E．磷脂11.可在机体内降解，降解产物或代谢产物安全无毒优衣的缓稀释材料是·······································································（）A．巴西棕榈蜡B．聚维桐C．聚丙烯D．聚乙烯E．聚乳糖三、多项选择题1.药用辅料在药物制剂中的作用是·····································（）A．是药物制剂的物质基础B．可改变药物的给药途径和作用方式C．可促进药物的吸收D．可改变药物的理化性质E．是提高制剂质量的关键2.目前我国已出台的药用辅料管理规定有····························（）A．《药用辅料注册申报资料要求》B．《药用辅料生产质量管理规范》C．《药品生产质量管理规范》D．《》E．《》3.在制药工业中，尤其是在天然药物提取及分离沌化过程中应尽可能使用，无须作溶剂残留量检查的溶剂有····························（）A．乙醇B．正丁醇C．丙酮D．乙醚E．甲醇4.在制药工业中应限制使用或尽可能避免使用，若使用，应作溶剂残留量检查的溶剂有···························································（）A．乙腈B．三氯甲烷C．环乙烷D．甘油E．甲苯5.常用的增溶剂有···························································（）A．对羟基苯甲酸酯类B．聚山梨酯类C．聚氧乙烯脂肪酸酯类D．珀珞沙姆E．泽类6.可供静脉注射用的乳化剂有···········································（）A．阿拉伯胶B．卵磷脂C．海藻酸钠D．珀珞沙姆188E．明胶7.适用于偏酸性药液的抗氧化剂是·····································（）A．亚硫酸钠B．亚硫酸氢钠C．焦亚硫酸钠D．硫代硫酸钠E．L-半朊氨酸盐酸盐8.可直接压片用的稀释剂常用···········································（）A．蔗糖B．淀粉C．改良淀粉D．喷雾干燥乳糖E．微晶纤维素9.在制备片剂时，常用作油类的良好吸收剂的是···················（）A．磷酸钙B．糊精C．葡萄糖D．碳酸钙E．蔗糖10.适用于遇水不稳定的药物，经非水溶剂溶解或润湿后具靠与性的黏合剂有····································································（）A．乙基纤维素B．聚维酮C．淀粉D．羟丙基甲基纤维素E．羧甲基纤维素钠11.二氧化钛在药物制剂中常用作·······································（）A．白色着色剂B．遮无剂C．润滑剂D．崩解剂E．黏合剂12.常用的肠溶衣材料有···················································（）A．羟丙基甲基纤维素B．乙基纤维素C．虫胶D．苯二甲酸醋酸纤维酯（CAP）E．聚丙烯酸树脂共聚物13.天然着色剂常用的有···················································（）A．焦糖B．姜黄色素C．江氧化铁D．苋菜红E．亮监14.包合物主体材料的作用主要有·······································（）A．增加药物的溶解性和生物利用度B．增加药物的稳定性C．液体药物固体化，防止挥发性成分的挥发D．掩盖药物的不良气味，减少刺激性，降低毒副作用E．调节药物的释放速度度15.包含物主体材料常用的品种有·······································（）A．山利酶B．糊精C．淀粉D．β-环糊精E．羟丙基-β-环糊精16.常用的油脂性软膏基质主要有·······································（）A．脂B．凡士林C．液体石蜡D．单硬脂酸甘油酯E．羊毛脂17.常用的水包油型（O/W）乳剂型—软膏基质有···················（）A．硬脂酰胺B．十六酶C．聚乙二酶D．十二烷基硫酸钠E．吐温8018.常用的水凝胶类缓控释材料有·····································（）A．海藻酸钠B．乙基纤维素C．壳聚糖D．卡波姆E．羟丙基甲基纤维素19.被称为三大超级崩解剂的是··········································（）A．交联羧甲基纤维素纳B．淀粉C．交联聚维酮D．交联羧甲基淀粉钠E．枸橼酸20.透皮促进剂常用的有···················································（）A．月桂酸B．二甲基亚矾C．月桂氮萆酮D．卡波姆E．油酸1.鱼肝油乳：处方：鱼肝油500ml阿拉伯胶（细粉）125g西黄芪胶（细粉）4g挥发杏仁油1ml糖精钠0.1g三氯甲烷2ml蒸馏水加至1000ml2.口结喷雾剂处方：金银花48g菊花72g板蓝根120g薄荷脑13g桉油2.5ml羟苯乙酯1g枸橼酸钠3.7g香精10ml枸橼酸钾3.8g乙酰磺胺酸钾1g甘油200g3.鱼腥草滴眼液处方：鱼腥草聚山梨酯80氯化钠硼酸-硼砂缓冲液4.氨茶碱片处方：氨茶碱1000g磷酸三钙500g预胶化淀粉150g滑石粉300g矿物油20g水适量5.呋喃唑酮片处方：呋喃唑柄片0.1g淀粉0.3g硬脂酸镁0.0025g羧甲基淀粉钠0.005g12%淀粉浆适量6.甲硝唑阴道泡腾片处方：甲硝唑2kg淀粉500g硼酸1kg枸橼酸1.5kg碳酸氢钠1.1kg羧甲基纤维素钠170g聚山梨酯80250g淀粉250g硬脂酸镁适量7.毛果芸香碱眼用膜剂处方：硝酸毛果芸香碱15g聚乙烯酸05-8828g甘油2g蒸馏水30ml8.复方雷公藤涂膜剂处方：雷公藤乙酸乙酯提取物15g冰片10g聚乙烯酸-12440g羧甲基纤维素钠20g甘油20g月桂氮草酮10g乙烯10g蒸馏水适量制成1000g9.富马酸美托洛尔脉冲片片芯处方：富马酸美托洛尔50mg乳糖80mg微晶纤维素30mg低取代羟丙基纤维素（内加）20mg羧甲基淀粉钠（外加）20mg滑石粉5mg10.包衣液处方：聚丙烯酸树脂（EudragitL100）与乙基纤维素比例为65：35聚乙二醇6000为质量分数15%11.徐长卿软膏：丹皮酚1g硬脂酸15g三乙醇胺2g甘油4g液体石蜡25ml羊毛脂2g蒸馏水50ml12.小剂量阿司匹林口腔崩解片处方：阿司匹林50g甘露醇105g微晶纤维素80g交联聚维酮20g碳酸氢钠20g枸橼酸20g硬脂酸镁20g微粉硅胶1g橘子香精2g甜菊糖适量