芽胞杆菌属-Microbiologyincludes

MedicalMicrobiologyDepartmentofMicrobiology,HMU第二篇致病性细菌第22章芽胞杆菌属Bacillus微生物学教研室李妍DepartmentofMicrobiology,HarbinMedicalUniversity教学大纲掌握内容炭疽芽胞杆菌主要生物学特性；致病物质及所致疾病微生物学检查法（Ascoli试验）了解内容炭疽芽胞杆菌的防治原则蜡样芽胞杆菌及其他需氧芽胞杆菌的分布及引起疾病DepartmentofMicrobiology,HarbinMedicalUniversity问题炭疽芽胞杆菌所致疾病炭疽芽胞杆菌的检查DepartmentofMicrobiology,HarbinMedicalUniversity动物源性细菌、动物源性疾病动物源性疾病动物源性细菌DepartmentofMicrobiology,HarbinMedicalUniversity芽胞杆菌属Bacillus一大群需氧或兼性厌氧、革兰阳性大杆菌炭疽芽胞杆菌炭疽病枯草芽胞杆菌败血症及虹膜炎蜡样芽胞杆菌食物中毒炭疽芽胞杆菌Bacillus.anthracisDepartmentofMicrobiology,HarbinMedicalUniversity形态与染色1.0～1.2μm×3.0～5.0μm革兰染色阳性杆状，两端平切，竹节状菌体中央椭圆形芽胞，不膨出DepartmentofMicrobiology,HarbinMedicalUniversity显微镜下的炭疽细菌胞子DepartmentofMicrobiology,HarbinMedicalUniversity培养特性需氧营养要求不高普通培养基中生长旺盛明胶培养管DepartmentofMicrobiology,HarbinMedicalUniversity抗原构造荚膜多肽抗原菌体多糖抗原芽胞抗原炭疽毒素复合物DepartmentofMicrobiology,HarbinMedicalUniversity抵抗力繁殖体抵抗力与一般细菌相同芽胞抵抗力强DepartmentofMicrobiology,HarbinMedicalUniversity致病物质荚膜炭疽毒素AnthraxtoxinDepartmentofMicrobiology,HarbinMedicalUniversity所致疾病炭疽Anthrax皮肤炭疽肠炭疽肺炭疽DepartmentofMicrobiology,HarbinMedicalUniversity免疫性感染炭疽后可获得持久的免疫力DepartmentofMicrobiology,HarbinMedicalUniversity微生物学检查法标本直接涂片镜检分离培养与鉴定炭疽抗原检查DepartmentofMicrobiology,HarbinMedicalUniversity防治原则控制动物炭疽炭疽减毒活疫苗预防接种长期被用作生物武器，提高生物防护措施治疗首选青霉素DepartmentofMicrobiology,HarbinMedicalUniversity蜡样芽胞杆菌生物性状革兰阳性大杆菌，两端钝圆周鞭毛，无荚膜，形成芽胞需氧或兼性厌氧致病食物中毒腹泻型食物中毒呕吐型食物中毒DepartmentofMicrobiology,HarbinMedicalUniversity小结炭疽芽胞杆菌主要生物学特性致病物质及所致疾病微生物学检查法（Ascoli试验）