AMPA受体

AMPA受体小组成员：谢亚磊，刘千琪，曹晨慧，汪洁，蒲聪颖，王顺莉，李珊，王涟漪，张晨，罗杰躁郁症的希望？bipolardisorder2extremeemotionalexpression:manic-highemotion,energetic,increasedspeech,increasedactivitydepressed-lowmood,anhedonia,decreasedenergy,reducedinterest,reducedactivityPathopoiesisPathogenesisPhysiologicalfactorsgeneticfactorssocialandpsychologicalfactorsclassificationTypeI:serveremaniaandslightdepressedTypeII:serveredepressedandslightmaniaInfluenceForoneself-livingunhappy,commitsuicideForothers-harmfulForsociety-burdenFormedical-burdenbipolardisorderout-offbalanceofneurotransmittermonoaminergicneurotransmitter(5-HT,NE)pooreffectGlutamateneurotransmitternewidea(prefereffect?)GlutamateAmajorexcitatoryneurotransmitterinthevertebrateCNSIonotropicGlutamatereceptor：AMPAreceptorNMDAreceptorkainatereceptorAMPAreceptor4subunits，GluR1-4,tetramereachsubunit:1extracellularNterminal+3TM+TM2+1intracellularCterminalmediateinternalflowofNa+,K+themigratoryofAMPAreceptorAMPAreceptorphosphorylation&dephosphorylation（GluR1）Ser845【PKA】PP1、PP2ASer831【CaMKII】PP1、PP2A躁郁lithiumvalproate(VPA)ClinicalsignificanceThankyou!!!