.4.03.0kcal/mol13.üüÅÅü««20Y20OR=RY=OR20OR.ZLehnWipff[CHOHNH]22&&K.SGexHhhh≠≠≠Khoa25-1-1Hh≠-1Sh≠Gh-25o≠-1-43-632-6K25oaex-1-1Hex≠-1Sex≠Gexo-≠25-1-53-732-8GGcleavconf≠≠Gkcal/mol)cleav≠Gkcal/mol)conf≠Gcleav≠Gconf≠CH3HOBF4CN+CH3CH3CH3CH3HOCN+CH3CH3BF4CH3HOCN+CH3OC2H554R=CH3555657R=C6C11R=C6C5R=(CH3)3CR-CONRR2RCONR2CH3HOCN+CH3BF4OC2H5CH3HOCN+CH3C6H5CH2CH3HOCN+CH3CH3CH3HOCN+CH3CH3C6H5CH3HOCN+CH3CH3CH3CH3137A138A148151-149-150-152-1531.0mol/LNaOH20801000pH12.712881000pH901001000pH701001000pH4010068320.1mol/LHCl010056440.5mol/LHCl010065351.5mol/LHCl010087133.0mol/LHCl010010006.0mol/LHCl01001000üBF.3-éCieplak..C—HC2—HaC6—HaC2—C3C5—C67A77A8.èèáüR=CHCOCFCHNHNHCHCN332222&&&&HegartyY=ClNCHO-3-3-RCCRNHCHCOOAlH45-23-4-&&ÅÅ.RCNN2+23129X=BF.4-129X=BF.4-13612132BF=ClO45137.4-4-ü-20--NHR2121N-His-57.--=----=--NHNRNHNRRRRR-22--=--NHNRRR