sensitivityinhealthypeopleduringtheconsumptionofanoliveoil-richdietJ.JClinEndocrinolMetab20059042297-2300.10BonenAParolinMLSteinbergGRetal.Triacylglycerolaccumu-lationinhumanobesityandtype2diabetesisassociatedwithincreasedratesofskeletalmusclefattyacidtransportandincreasedsarcolemmalFAT/CD36J.FASEBJ200418101144-1146.11WatanabeKNakazatoYSaikiRetal.Acrolein-conjugatedlow-densitylipoproteininducesmacrophagefoamcellformationJ.Atherosclerosis2013227151-57.12WilmsenHMCiaraldiTPCarterLetal.Thiazolidinedionesupregulateimpairedfattyaciduptakeinskeletalmuscleoftype2diabeticsubjectsJ.AmJPhysiolEndocrinolMetab20032852E354-E362.13ConnellyMAWilliamsDL.ScavengerreceptorBIascavengerreceptorwithamissiontotransporthighdensitylipoproteinlipidsJ.CurrOpinLipidol2004153287-295.14VanEckMTwiskJHoekstraMetal.Differentialeffectsofscav-engerreceptorBIdeficiencyonlipidmetabolismincellsofthearterialwallandintheliverJ.JBiolChem20032782623699-23705.15LamharziNRenardCBKramerFetal.Hyperlipidemiainconcertwithhyperglycemiastimulatestheproliferationofmacrophagesinatheroscleroticlesionspotentialroleofglucose-oxidizedLDLJ.Diabetes200453123217-3225.16HubyTDoucetCDachetCetal.KnockdownexpressionandhepaticdeficiencyrevealanatheroprotectiveroleforSR-BIinliverandperipheraltissuesJ.JClinInvest2006116102767-2776.17MineoCShaulPW.FunctionsofscavengerreceptorclassBtypeⅠinatherosclerosisJ.CurrOpinLipidol2012235487-493.18SvenssonLCamejoGCabréAetal.FattyacidsmodulatetheeffectofdarglitazoneonmacrophageCD36expressionJ.EurJClinInvest2003336464-471.19KimHHaluzikMGavrilovaOetal.Thiazolidinedionesimproveinsulinsensitivityinadiposetissueandreducethehyperlipidaemiawithoutaffectingthehyperglycaemiainatransgenicmodeloftype2diabetesJ.Diabetologia200447122215-2225.20TanGDFieldingBACurrieJMetal.Theeffectsofrosiglitazoneonfattyacidandtriglyceridemetabolismintype2diabetesJ.Diabetologia200548183-95.21FazioSLintonMF.InterplaybetweenapolipoproteinEandscaven-gerreceptorclassBtypeⅠcontrolscoronaryatherosclerosisandlifespaninthemouseJ.Circulation2005111253349-3351.22ZhangSPicardMHVasileEetal.Diet-inducedocclusivecoro-naryatherosclerosismyocardialinfarctioncardiacdysfunctionandprematuredeathinscavengerreceptorclassBtypeI-deficienthypomorphicapolipoproteinER61miceJ.Circulation2005111253457-3464.23CaoWMMuraoKImachiHetal.Insulin-likegrowthfactor-ireg-ulationofhepaticscavengerreceptorclassBIJ.Endocrinology2004145125540-5547.24SvenssonPAEnglundMCSnckestrandMSetal.RegulationandsplicingofscavengerreceptorclassBtypeⅠinhumanmacropha-gesandatheroscleroticplaquesJ.BMCCardiovascDisord2005525.2013-08-192013-12-04辛欣李潮生1△陈军2※1.5240002.518100R363A1006-2084201413-2317-03doi10.3969/j.issn.1006-2084.2014.13.0062012年广东省社会发展领域科技计划项目课题(20120318093)SSAO。SSAO、。SSAO。SSAO、、。SSAO。TheResearchProgressofSemicarbazide-sensitiveAmineOxidasewithCardiovascularDiseaseandDiabetesLIChao-sheng1CHENJun2.1.PostgraduateDepartmentofGuangdongMedicalCollegeZhan-jiang524000China2.CardiovascularDepartmentShenzhenBao'anPeople'sHospitalShenzhen518100ChinaAbstractSemicarbazide-sensitiveamineoxidaseSSAOispresentwidelyinhumanbodyandhasvariousphysiologicalfunctions.Oxidativedeaminationofshort-chainprimaryaminesiscatalyzedbythisenzymetoaffordthecorrespondingaldehydeshydrogenperoxideandammonia.MethylamineandaminoacetonearephysiologicalsubstratesforSSAO.PlasmaSSAOactivityincreasessignificantlyonpatientswithcardiovas-culardiseaseanddiabetes.Toxicaldehydeproductsmaycontributetotheendothelialinjuryofbloodvesselsandoxidativestressthuspromotingatherosclerosisandcomplicationsofdiabeticangiopathy.Thereforepatho-physiologicresearchofSSAOwithcardiovasculardiseaseanddiabeteshasbecomeanewresearchhotspot.KeywordsSemicarbazide-sensitiveamineoxidaseInhibitorsAtherosclerosisDiabetessemicarbazide-sensitiveamineoxidaseSSAO、hydrogenperoxideH2O2。、、、、、SSAO1-3SSAO、。1SSAOmonoamineoxidaseMAO-AMAO-B。、SSAO、、SSAO1vascularadhesionpro-tein-1VAP-14。SSAOMAOMAOSSAO5。·7132·201472013MedicalRecapitulateJul.2014Vol.20No.132SSAO2.1SSAOSSAOD2、D3、D46。SSAOSSAO6SSAO7。SSAO--SSAO、。SSAO180×1031molSSAO2mol、1mol16-SSAO8。2.2SSAOSSAO1717q21SSAOAOC1、AOC2、AOC3、AOC4。AOC1、、9AOC2SSAO10AOC3SSAO/VAP-1、、、、11。AOC422512。SSAOSSAOSSAOSSAOSSAO。SSAOSSAO80%5。2.3SSAOSSAO、H2O2。SSAOSSAOMAO、。、SSAO、H2O213。SSAO。3SSAOVAP-1SSAO、14。SSAO/VAP-1、H2O2、。SSAO、-DNA。H2O2。SSAOH2O2、advancedglycatedendproductsAGEsAGEs15。、16VAP-1、、15。17SSAO/VAP-1SSAO/VAP-118。SSAO/VAP-1、、。、、SSAO。SSAO/VAP-1/40%SSAO/VAP-1/19。Yang20/SDSSAO3minSSAOSSAO-。Marinho21SSAOSSAO、、。Li226612VAP-15.8395%CI1.17~28.97。VAP-12。4SSAO。、、。SSAOSSAO、。SSAO、。Almulki23VAP-1。Yoshikawa242VAP-1SSAO/VAP-1AGEsSSAO、、25。Valente3SSAO/VAP-1AGEs、AGEs、1SSAO/VAP-1。Li2611530minSSAO/VAP-12hSSAO/VAP-1、AGEs、SSAO/VAP-1。SSAO/VAP-1、、AGEs、。5SSAOSSAO、。SSAOSSAO·8132·201472013MedicalRecapitulateJul.2014Vol.20No.13、、AGEs。SSAO27。SSAO。semicarbazide、aminogua-nidineE-2-4--3-MDL72974A、E-2-34--3-MDL72145。2-。SSAO、。、、SSAOSSAO22228。6、、SSAO。SSAO/VAP-1、SSAO/VAP-1。SSAO。SSAOSSAO、。1NodaKNakaoSZandiSetal.Vascularadhesionprotein-1regu-latesleukocytetransmigrationrateintheretinaduringdiabetesJ.ExpE