2090CODBOD5Fe3O4Fe3O4Fe3O4XXPS)HRTEM(VSM)610nmCODFe3O4VIIIIXcoagulationfactor-VIIIorcoagulationfactor-IXF-VIIIorF-IX)embryonicstemcellESCVIIIIXHemophiliaVIII/IXVIIIIXABVIIIIXVIIIIXIIVVIIVIIIIXXVIIIIX200VIIIIXABVIIIIXVIIIIX[ActaPharmacologicaSinica2010:1-9]8634BMP-4(bFGF)(HGF)M(OSM)(DEX)RT-PCRreal-timePCRwesternblot70%ELISABMP-4bFGFVIIIIX351.indd182011-1-717:1:1