,,,1920206020,,,1999,1,36.8%,21%,,,,,,,:(KMnO4)158.03,2.073g/cm3,,,,(),PH,(MnO22H2O),,:3Mn2++2KMnO-4+2H2O=5MnO2+2K++4H+,1mg1.9mg,,,,,2006,,,,2007,()(),:,4-8,(1),,,,,5m,,,20074,,1.0,0.05mg/L7,,50NTU300NTU,,0.2mg/L,1.0,0.05mg/L0.2mg/L,1.0DOI:10.16661/j.cnki.1672-3791.2009.34.065,0.05mg/L,2.5,0.01mg/L2,,1,,,,,,2.5,,,,,,0.1mg/L,,,,,,22.5,,(3),,,,,PH,PH,,,,,,,PH,,,,,,,,;,,510,,,11.5(1)PEG-(PEG-maleimide)(3);(2)PEG---(PEG-ortho-pyridyl-disulphide);(3)PEG-(PEG-vinylsulfone);(4)PEG-(PEG-idoacetamide),PEG-,Winslow[7]PEG,,,,PEG,Traut,PEG,,(4),,,,,,PEG:1PEG(2)PEG(3)[8]PEGPEGPEG,PEG[1],.[M].:,,1999:118.[2]KoderaY,MatsushimaA,HirotoM,etal.Pegylationofproteinsandbioactivesubstancesformedicalandtechnicalapplications[J].ProgPolymerSci,1998,23:12331271.[3]InadaY,FurukawaM,SasakiH,etal.Biomedicalandbiotechnologicalap-plicationsofPEGmodifiedproteins[J].TrendsBiotechnol,1995,13:8691.[4]AbuchowskiA,VanET,PalczukNC,etal.Alterationofimmunologicalprop-ertiesofbovineserumalbuminbycovalentattachmentofpoly(ethyleneglycol)[J].JBiolChem,1977,252:35783581.[5],,.[M].:,1995:122157.[6],.[J].,2001,21(8):2528[7]ManjulaBN,TsaiA,UpadhyaR,etal.SitespecificPEGylationofhemoglo-binatCys293(beta):correlationbe-tweenthecolligativepropertiesofthePEGylatedproteinandthelengthoftheconjugatedPEGchain[J].BioconjugChem,2003,14(2):464472.[8],,,.[J].,2002,37(6):409412.