TheNewEnglandJournalofMedicineDownloadedfromnejm.orgatPEKINGUNIVERSITYonSeptember24,2016.Forpersonaluseonly.Nootheruseswithoutpermission.Copyright©1993MassachusettsMedicalSociety.Allrightsreserved.TheNewEnglandJournalofMedicineDownloadedfromnejm.orgatPEKINGUNIVERSITYonSeptember24,2016.Forpersonaluseonly.Nootheruseswithoutpermission.Copyright©1993MassachusettsMedicalSociety.Allrightsreserved.TheNewEnglandJournalofMedicineDownloadedfromnejm.orgatPEKINGUNIVERSITYonSeptember24,2016.Forpersonaluseonly.Nootheruseswithoutpermission.Copyright©1993MassachusettsMedicalSociety.Allrightsreserved.TheNewEnglandJournalofMedicineDownloadedfromnejm.orgatPEKINGUNIVERSITYonSeptember24,2016.Forpersonaluseonly.Nootheruseswithoutpermission.Copyright©1993MassachusettsMedicalSociety.Allrightsreserved.TheNewEnglandJournalofMedicineDownloadedfromnejm.orgatPEKINGUNIVERSITYonSeptember24,2016.Forpersonaluseonly.Nootheruseswithoutpermission.Copyright©1993MassachusettsMedicalSociety.Allrightsreserved.TheNewEnglandJournalofMedicineDownloadedfromnejm.orgatPEKINGUNIVERSITYonSeptember24,2016.Forpersonaluseonly.Nootheruseswithoutpermission.Copyright©1993MassachusettsMedicalSociety.Allrightsreserved.TheNewEnglandJournalofMedicineDownloadedfromnejm.orgatPEKINGUNIVERSITYonSeptember24,2016.Forpersonaluseonly.Nootheruseswithoutpermission.Copyright©1993MassachusettsMedicalSociety.Allrightsreserved.