搜索
2002,22(5)387~391ChinaEnvironmentalScience1,1,1,1,2(1.,2100932.,210048)βX171.5A2002)05038705Effectsofcyclodextrinanditsderivativesonthetoxicityofnitrocompounds.KONGDe-yang1,GAOShi-xiang1,LINZhi-fen1,WANGLian-sheng1,JIANGXin2(1.StateKeyLaboratoryofPollutionControlandResourceReuse,SchooloftheEnvironment,NanjingUniversity,Nanjing210093,ChinaInstituteofSoilScience,ChineseAcademyofSciences,Nanjing210048,China).ChinaEnvironmentalScience.2002,22(5)387~391AbstractTheeffectofcyclodextrinanditsderivativesofdifferentconcentrationontheacutetoxicitiesofseveralnitrobenzenederivativestophotobacteriumphosphoreumwasstudiedwithluminousbacteriumacutetoxicityassay.Cyclodextrinanditsderivativescouldsignificantlyreducetheapparenttoxicityoforganicpollutants,andthusthehalfdepressionconcentrationofnitrocompoundstophotobacteriumphosphoreumbiotoxicitywasenhancedto1.7~22.4times.Theeffectofcyclodextrinonreducingthetoxicityoftheinvestigatedcompoundsisrelatednotonlywiththehydrophobicityofthecompounds;butalsosignificantlyinfluencedbythematchingdegreeofthecompoundswiththecyclodextrincavityandthestructureofinclusioncomplex.Keywordscyclodextrinphotobacteriumphosphoreumacutetoxicityinclusioncomplex,,,,,[1,2].β[1],5g/Lβ,.[3]β(CMCD)8(SIC),β,.SIC/CMCD,,.,â,â[4,5]...,â,â20020128(20077013);(2000028423)*38822αβγ.11.1DXY-2(),;;.β,(99%);αβγ(Aldrich),,0.6;,.1.2[6],,,15min-EC50.=(/)×100%,âαβγ,15min-EC50.22.1β501.2.1.11,,.,1:1[7],(CD)(NB),:,,.,.(1),,.,,.,,,,,,.1βFig.1Effectofβcyclodextrinonthetoxicityofnitrocompounds´2.1.24,.,.,,,.,,,,.CD+NBCDNB(1)010203040506001234mmol/Lmg/L5389;;,.,.,,,.,.,.,.,.,.[1]15,/.4,,.,..41.1,/,,,.,,2A.,.,,,.,,,,2B(R).,,,.1Table1SelectedofparametersofnitrobebenzenederivativesandcomparisonofexperimentalresultsKOW(nm)(nm)1.476.3714.3483.422.986.9524.3544.501.567.0134.3542.482.466.2384.8461.842Fig.2Illustrationofcyclodextrin-nitrocompoundcomplexes2.2áâãáâã1NO23,4.3,43,3.2.3(1mmol/L),3,ClO2NANO2RB390221.7.(50mmol/L),áâ,3.7,ã.,,,[8].3,áâ,;ã,.,ãáâ.2(nm)Table2Selectedparametersofcyclodextrinandcompounds(nm)α4.75.37.9±0.1β6.06.57.9±0.1γ7.58.37.9±0.14.3547.01314.356.117.3883Fig.3Effectofcyclodextrinderivativesonthetoxicityofnitrobenaldehydeαβγ31.50mmol/L,áâã113.822.45.5,â.41Fig.4Effectofcyclodextrinderivativeonthetoxicityof1-nitronaphthaleneαβγ2,13,á,âã.1,,.á,12:1,;âã,1,.,ã1,1ã(5).,,,AB.A,,.ã1.,1,1,.,051015202501020304050mmol/L(mg/L)010203040506001020304050mmol/L(mg/L)5391,,1.,12:1,.5ãFig.5Structureillustrationofhydroxypropylãcyclodextrincomplex3,,..,,,;,.[1]SongWenlu,HuangQingguo,WangLiangsheng.β-Cyclodextrininfluenceonthebiotoxicitiesofsubstitutedbenzenecompoundsandpesticideintermediates[J].Chemosphere,1999,38(4):693698.[2]MarmoruKamiya,KaoriNakamural.Cyclodextrininclusioneffectsonphotodegradationratesoforganophosophoruspesticide[J].EnvironmentInternational,1995,21(5):299304.[3].[D].:,2000.[4]ZhangMQ,ReesDC.Areviewofrecentapplicationsofcyclodextrinsfordrugdiscovery[J].ExpertOpinionOnTherapeuticPatents,1999,9(12):16971717.[5],.[J].,1998,6(4)8086.[6],.[J].,2001,22(2):114117.[7],.[M].:,1994.7996.[8]LeiLiu,GuoQingXiang.ThedrivingforcesintheInclusioncomplexationofcyclodextrins[J].JournalofInclusionPhenomenaandMacrocyclicChemistry,2002,42:114.(1976),,,,.3.Pachauri20024,RajendraPachauri7649RobertWatson,(IPCC).,.Watson,.14,3.,IPCC.IPCC,192.Pachauri,Watson..Science,April26,632(2002)NO2ANO2B