家族性颅内多发性海绵状血管瘤3例报告

31,1,1,1,2(1.,110001;2.)[]3,(MRI),,,MRI[];[]R743.4[]B[]0258-4646(2006)01-0100-02(cavernousangioma,CA),,[1](intracranialCA,ICA),(familialICA,FICA)3FICA11,,33199497d,6d:,,,(L:++,R:+),(L:++,R:+),(L:++,R:+),Babinski(-)(),,22,4,19982,4d,2d:,,,,,,,,,,,(L:+++,R:++),Babinski(+)(+),:MRI:,T1,(1A)MRI:(1B),,342,,57,12004720,,,,:,,,MRI(1C)MRIICA3,31,1200461MRI(1D):ICA13MRIFICA2;;;;2[](1978-),,1:12FICA,7q11.2221,1(cerebralcavernousmalformation21gene,CCM21)[2]ICA[3],,,,,,,[4],,001JChinMedUniv35120062,MRI,T1,,T2,,,[5]ICACA,,,,,,,,,[6]3cm,CAX,,,,,,MRI,,12,,,,3,MRI,,,1,,,,,,,,2060,,,,MRI,:[1],,,.2[J].,2004,21(6):501.[2]GUNELM,AWADIA,ANSONJ,etal.Mappingagenecausingcerebralcavernousmalformationto7q11.2-q21[J].ProcNatlAcadSciUSA,1995,92(14):6620-6624.[3],.(14)[J].,2003,2(3):242-244.[4],.[M].//.,:,2001:880-883.[5],,.29[J].,2003,20(7):525-526.[6],,,.[J].,2000,5(1):82-84.[]2004-11-0933,,,(,110001)[]33,,[];[]R725[]B[]0258-4646(2006)01-0101-01(hypereosinophilia,HE)(eosinophilcell,EC)HE1990200433HE,11.11990120045HE33,22,111.514,10d6EC(1.291.52)109/L,(17.9921.75)109/L1.21.2.1:EC7%,0.5109/L[1][](1963-),,,.:.1.2.2::EC0.070.15,0.51.5109/L;:EC0.150.50,1.55.0109/L;:EC0.500.90,5.0109/L[1]1.2.3:3322.1(pulmonaryinfiltra2tiveeosinophilia,PIE)()10,64;1;11,722();(hypereosi2nophilicsyndrome,HES)11,1()1,19,57.6%2.2,101JChinMedUniv35120062