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100020A6AVA144551428VA146866928775792462940402～58761VA≤0.70µmol/L101811.7%1505.2%86815.0%23.3%1455.8%35511.5%51816.8%VA1.06µmol/L1.200.99µmol/L6VA≤0.70µmol/L33.4%4～58%VAVAASurveyonvitaminAdeficiencyinchildrenunder-6-yearsinChinaLINLiangming*LIUYulinMAGuanfuTANZangwenZHANGXinliJIANGJingxiongSONGXiaofangWANGLiZHANGJiannaWANGHeruLIMei.*DepartmentofEpidemiologyCapitalInstituteofPediatricsBeijing100020ChinaAbstractObjectiveTounderstandtheprevalenceandspatialdistributionofvitaminAdeficiencyVADinChinaamongchildrenatagesundersixyears.MethodsAbout8600childrenunder6yearsofagein14citiesand28countiesof14provinceswereselectedwithstratifiedclustersamplingforsurveyincludinginterviewwithquestionnairefortheirfamilyinformationandnutritionalstatus.BloodspecimenswerecollectedformeasuringserumlevelofVAwithfluorescentspectrophotometryinlaboratory.ResultsTotally8669childrenunder62877inurbanareaand5792inruralareaweresurveyedin14provinceswith4629malesand4040females.Eightcasesofnightblindnessandsevencasesofxerophthalmiawerefoundamongthechildrenatagesoftwotofiveyears.Sixty-onemothersofthechildreninthisgroupwerealsofoundsufferingfromnightblindness.Allthecasesofnightblindnessandxerophthalmiabothinchildrenandmotherswerelivinginruralareas.BasedontheirserumlevelsofVA11.7%oftheall1018childrenwerediagnosedasVADwithserumVAconcentrationsbeloworequalto0.70µmol/L.PrevalenceofVADwas15.0%and5.8%inrural23.3%inthepoverty-strickencountiesandurbanareasrespectivelyand5.8%11.5%and16.8%inthecoastalinlandandremoteareasrespectively.TheaverageserumlevelofVAwas1.20µmol/Land0.99µmol/Lforurbanandruralareasrespectivelywithanationalaverageof1.06µmol/L.AndbabiesundersixmonthsofagewithanaverageserumlevelsofVA≤0.70µmol/Laccountedfor33.4%andthoseatagesoffourtofiveyearswiththesamelevelofVAaccountedfor8%.TherewassignificantdifferenceinserumlevelsofVAbetweenagesbutnosignificantdifferencebetweengenders.ConclusionVADdidexistinchildrenofChinaespeciallyintheremoteandpoverty-strickenruralareasandVAsupplementationisurgentlyneededforthechildrenintheseregions.KeywordsVitaminAdeficiencyChildpreschoolDatacollectionAVA90VA2000VA12VA14199912～20003VA51320029365ChinJPrevMedSeptember2002Vol36No.51.31VA455361461242142820～520033231998322.0.2mlVA4h-20℃6h-70℃VAVACDC3.EpinfoFtx2VAVA4.VAVABitotVA≤0.70µmol/L0.70～1.05µmol/LVA5.42495%CDCCDC1.33µmol/L1002.9%～9.9%598.2%～108.8%102.2%VA21VA43dR20.99～0.999941.1468669287757924629404024～7159148761VA2.VA1VA1866910～5A%%%%1230473.83.829624.121.816471036.36.752231.730.912351219.88.149039.739.5166721913.111.174244.542.2187528615.315.785945.847.5101524223.823.348748.050.024981455.85.587735.136.5308535511.510.0120439.039.4308651816.820.4131542.661.528771505.25.681828.427.4579286815.012.5257844.543.78669101811.711.2339639.240.6A≤0.70µmol/LA0.70～1.05µmol/LP=0.00061320029365ChinJPrevMedSeptember2002Vol36No.520～5Aµmol/L-x±sFP6221.23±0.346081.30±0.311.60.00112301.26±0.378551.15±0.317921.14±0.30.10.81016471.14±0.316971.08±0.335381.09±0.30.30.58012351.08±0.348831.00±0.307841.02±0.31.00.67816671.01±0.3010270.97±0.288480.98±0.21.70.60818750.97±0.285450.91±0.294700.91±0.30.00.91510150.91±0.3013591.12±0.3011391.15±0.36.80.00924981.14±0.3216691.04±0.3114161.07±0.39.90.00230851.06±0.3116011.00±0.3414851.01±0.30.10.77430861.01±0.3514771.18±0.3314001.21±0.35.50.01828771.20±0.3431520.99±0.3026401.00±0.31.20.27257920.99±0.3146291.05±0.3240401.07±0.39.00.00386691.06±0.33P=0.0000～51018VA≤0.7µmol/L11.7%11.2%VA0.70～1.05µmol/L339639.2%40.6%VA33VA23.8%3.8%6.3VA1.06µmol/L1.05µmol/L1.07µmol/LVA2VA3A%%61182521.25647.56～307299.412540.71～504244.813927.62～926424.524126.04～51022302.925725.128771505.281828.462419539.410844.86～53612222.826248.91～104917416.649947.62～194026213.583342.94～5202621510.687643.2579286815.0257844.5635912033.416445.76～84315117.938745.91～155319812.763841.12～286630410.6107437.54～530482458.0113337.28669101811.7339639.2A≤0.70µmol/LA0.70～1.05µmol/LP=0.0002VAVA3VAVA66VA≤0.70µmol/L33.4%21.2%39.4%3VA485.7%VA0.70～1.75µmol/L1.75～2.45µmol/L2.2%2.45µmol/L0.3%14VA10%6VA36.0%VAWHO19953000～5VA2.51VA5VA6144286690～5VAVAVAVA78287VA0.15%71320029365ChinJPrevMedSeptember2002Vol36No.54140～5A%20242.03416.8440286.417940.7642325.021333.218342.23921.34304410.216337.9613487.820233.020110.54321.4407399.619046.7608406.623338.322100.02913.1414256.020048.3635253.922936.1201105.08542.3395328.116040.5596427.024541.121494.27535.0417194.615637.4631284.423136.620973.34320.6415225.317742.7624294.622035.3210167.68741.4407184.414134.6617345.522837.02044723.08340.741317542.419747.761722236.028045.42042311.37838.24058621.220550.660910917.928346.5218188.39342.74189923.721551.463611718.430848.420952.45727.342511326.620147.363411818.625840.719331.62714.04039724.118345.459610016.821035.220831.44521.64037117.621152.46117412.125641.928771505.281828.4579286815.0257844.58669101811.7339639.2x2=631.6P=0.000VAVA2VA1%VAVAVA≤0.70µmol/L≥2%～10%≥10%～20%≥20%98669VA≤0.70µmol/L11.7%11.2%VAVA23.8%36%VAVA①3②3③6.3VAVAVAVA4～5VA0.70µmol/L8.0%633.4%6VAVAVA6～716VAVA199738VA35VA40VA27VA45VA10VAVA23%～3